Reporting dinaciclib and theodrenaline as a multitargeted inhibitor against SARS-CoV-2: an in-silico studyArticle Published on 2023-06-012023-07-08 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), [키워드] main protease molecular docking Molecular dynamics simulation NSP15-endoribonuclease papain-like protease. SARS-CoV-2 [DOI] 10.1080/07391102.2022.2060308 PMC 바로가기
Evaluation of phytoconstituents of Tinospora cordifolia against K417N and N501Y mutant spike glycoprotein and main protease of SARS-CoV-2- an in silico studyArticle Published on 2023-06-012023-07-08 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), [키워드] main protease MD simulation SARS CoV-2 spike glycoprotein. Tinospora cordifolia [DOI] 10.1080/07391102.2022.2062787 PMC 바로가기
SARS-CoV-2 main protease inhibitors: What is moving in the field of peptides and peptidomimetics?Article Published on 2023-05-012023-07-11 Journal: Journal of peptide science : an official publication of the European [Category] COVID19(2023년), [키워드] covalent COVID-19 inhibitors main protease MPro peptides peptidomimetics. SARS-CoV-2 [DOI] 10.1002/psc.3467 PMC 바로가기
Peptide Amphiphile Mediated Co-assembly for Nanoplasmonic SensingArticle Published on 2023-01-232023-07-10 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), [키워드] Aromatic Interactions Colorimetric test main protease Peptide Amphiphile Saliva. [DOI] 10.1002/anie.202214394 PMC 바로가기
Fullerene derivatives as inhibitors of the SARS-CoV-2 main proteaseArticle Published on 2023-01-152023-07-11 Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), [키워드] COVID-19 Fullerene main protease SARS-CoV-2. [DOI] 10.1016/j.bmcl.2022.129121 PMC 바로가기
Triterpenic Acid Amides as Potential Inhibitors of the SARS-CoV-2 Main ProteaseArticle Published on 2022-12-302023-07-11 Journal: Molecules [Category] COVID19(2023년), [키워드] Antiviral FRET main protease Molecular modeling SARS-CoV-2 triterpene amide. [DOI] 10.3390/molecules28010303 PMC 바로가기
In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2Article Published on 2022-12-012023-07-10 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] Anti-SARS-CoV-2 in vivo FB2001 main protease PBPK SARS-CoV-2 SARS-CoV-2 variants. [DOI] 10.1016/j.antiviral.2022.105450 PMC 바로가기
Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomesArticle Published on 2022-11-122022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Adaptability Antiviral approved circulating coronavirus correlation COVID-19 cases COVID-19 pandemic develop drug resistance FDA highest hotspot intracellular protein Like M pro main protease Mild-to-moderate mutant Mutation mutations Nirmatrelvir offer omicron predicted Probability protease Protein design reported residue residues resistance resistance mutations robust SARS-CoV-2 SARS-CoV-2 lineage signature Signatures of adaptation. Surveillance unique variant Variation variations viral adaptation viral genome viruses [DOI] 10.1016/j.bbrc.2022.09.010 PMC 바로가기
Molecular interactions and inhibition of the SARS-CoV-2 main protease by a thiadiazolidinone derivativeArticle Published on 2022-11-012022-11-15 Journal: Proteins [Category] COVID19(2023년), SARS, 치료제, [키워드] comparable conformational docking enzyme inhibitor Interaction involved Local main protease molecular molecular dynamics Molecular dynamics simulation molecular interaction Pro probe protease protocol SARS-CoV-2 the SARS-CoV-2 thiadiazolidinone. viral life cycle [DOI] 10.1002/prot.26385 PMC 바로가기
A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 보세프레비르 기반 주요 프로테아제 억제제의 체계적인 탐색Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 293T cell 293T cells active site Alanine aldehyde amide Antiviral antiviral potency boceprevir Carbamate carbamide changed characterized complex covalent inhibitor COVID-19 crystal structure crystal structures cysteine cytotoxicity expressed HCV hydrophobic hydrophobic interaction IMPROVE in vitro inhibit inhibitor inhibitors isovaleramide M pro main protease Modification modifications N-terminal nitrile observation Opal PF-07321332 Pro protease Protease inhibitor recognize residue reversed SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variants SARS-CoV-2. side chain substrate tested the SARS-CoV-2 undetectable unique warhead [DOI] 10.1016/j.ejmech.2022.114596 PMC 바로가기 [Article Type] Article