[Discovery of SARS-CoV-2 main protease inhibitors using an optimized FRET-based high-throughput screening assay]Article Published on 2022-06-252023-07-09 Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Category] COVID19(2023년), [키워드] fluorescence resonance energy transfer (FRET) ginkgolic acid High-throughput screening Main protease inhibitor plumbagin. SARS-CoV-2 [DOI] 10.13345/j.cjb.210657 PMC 바로가기
[Identifying SARS-CoV-2 main protease inhibitors by a novel sandwich-like fluorescence polarization screening assay]Article Published on 2022-06-252023-07-09 Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Category] COVID19(2023년), [키워드] Anacardic acid Fluorescence polarization High-throughput screening Main protease inhibitor pentagalloylglucose. SARS-CoV-2 [DOI] 10.13345/j.cjb.210949 PMC 바로가기
Structure-based identification of potential SARS-CoV-2 main protease inhibitors잠재적인 SARS-CoV-2 주요 프로테아제 억제제의 구조 기반 식별Article Published on 2022-05-012022-09-12 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 진단, [키워드] ADMET approach approach bind complex Complexes coronavirus disease COVID-19 COVID-19 infection COVID19 docking drug design Drug screening drug target drug-likeness effective enzyme FIVE high affinity inhibitor inhibitors of SARS-CoV-2 M pro Main protease inhibitor MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations pharmacophore pharmacophore modeling protease protein-ligand required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease SARS-CoV-2. these compound Vaccine viral replication [DOI] 10.1080/07391102.2020.1848634 PMC 바로가기 [Article Type] Article
Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitorsMethodology Published on 2021-12-052022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] 3CL protease inhibitor acute respiratory syndrome Analysis antiviral agent approved BAS catalytic site caused Chinese traditional medicine conserved coronavirus coronavirus disease COVID-19 COVID-19 patients develop development Dieckol docking Ecklonia cava enzyme evaluated exhibited Fluorescence polarization genomic RNA high affinity High-throughput screening highest identify in viral in vitro inhibitor Interaction Main protease inhibitor MPro pandemic polyprotein predicted protease Proteases Replication Result SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro selective SPR Spread therapeutic agent therapeutic target Treatment [DOI] 10.1186/s13578-021-00720-3 PMC 바로가기 [Article Type] Methodology
Protease inhibitor GC376 for COVID-19: Lessons learned from feline infectious peritonitisCorrespondence Published on 2020-12-282022-10-04 Journal: Annals of Medicine and Surgery [Category] 신약개발, 치료제, [키워드] acute respiratory syndrome antiviral drug conducted coronavirus coronavirus Coronavirus infection COVID-19 develop diarrhoea drug candidate Efficacy Epidemic evaluate Feline coronavirus Feline infectious peritonitis help humans inhibit inhibitor lesson M pro Main protease inhibitor maturation Middle East patients with COVID-19 polyprotein protease Protease inhibitor respiratory syndrome coronavirus SARS-CoV-2 therapeutic target Therapeutics trials virus viruses [DOI] 10.1016/j.amsu.2020.12.030 PMC 바로가기 [Article Type] Correspondence