MAPK3 – Communicable Diseases Research

Bioinformatics analysis of potential pathogenesis and risk genes of immunoinflammation-promoted renal injury in severe COVID-19

Article

Published on 2022-08-162022-11-15
Journal: Frontiers in Immunology
[Category] 바이오마커,

Glycyrrhetinic acid: A potential drug for the treatment of COVID-19 cytokine storm

Glycyrrhetinic acid : Covid-19 사이토 카인 폭풍의 치료를위한 잠재적 약물

Article

Published on 2022-07-202022-08-31
Journal: Phytomedicine : international journal of phytother
[Category] 신약개발, 유전자 메커니즘, 치료법, 치료제,

[키워드] Analysis caused core genes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cytokine storm cytokine Cytokine storm database docking result effective ESR1 experiment experimental results Experimental verification experiments Glycyrrhetinic acid Health Human IL-17 IL6 immune in vitro in vivo Infection Inflammatory inhibit inhibitory effect Interaction Intervention KEGG Kyoto lack lipopolysaccharide MAPK3 mechanism molecular docking molecule network network pharmacology Network pharmacology. Ontology pathway pathway enrichment PPAR signaling PPARG PPI PPI network predict protein-protein interaction Proteins PTGS2 R language Research screened signaling pathway signaling pathways significantly target gene Target genes targets TNF TNF signaling treat Treatment triggered Venn diagram was performed
[DOI] 10.1016/j.phymed.2022.154153 PMC 바로가기 [Article Type] Article

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience
[Category] 유전자 메커니즘,

[키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease
[DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article

Potential mechanism of action of Jing Fang Bai Du San in the treatment of COVID-19 using docking and network pharmacology

Research Paper

Published on 2022-01-012022-10-29
Journal: International Journal of Medical Sciences
[Category] COVID-19,

[키워드] 3CLpro acute respiratory syndrome Analysis applied caused chymotrypsin common cold coronavirus Coronavirus disease 2019 cough COVID-19 docking EGFR enzyme II Epidemic facilitate Fang headache HIF-1 host cells IL2 indicated infect ingredient inhibit JingFangBaiDu San LCK MAPK MAPK1 MAPK3 MAPK8 mechanism mechanism of action molecular docking network network pharmacology NF-κB Pathogens pathway Perspective PIK3CA Potential potential mechanism prevalent protease provide receptor signaling RELA Replication SARS-CoV-2 Spike protein Spread STAT3 Structure therapeutic effect therapeutic targets TNF Toll-like receptors treat Treatment treatment for COVID-19 virus entry
[DOI] 10.7150/ijms.67116 PMC 바로가기 [Article Type] Research Paper

Medical Significance of Uterine Corpus Endometrial Carcinoma Patients Infected With SARS-CoV-2 and Pharmacological Characteristics of Plumbagin

SARS-CoV-2에 감염된 자궁체부 자궁내막암 환자의 의학적 의의 및 Plumbagin의 약리학적 특성

Endocrinology

Published on 2021-10-122022-09-11
Journal: Frontiers in Endocrinology
[Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analysis Anti-inflammation Anti-inflammatory Apoptosis bioinformatics Cancer candidate clinical Clinical characteristics conducted coronavirus coronavirus disease corpus COVID-19 COVID-19 in patient cytotoxicity disease Effect Endometrial Carcinoma Evidence functions Genes Health identify immunomodulating immunomodulation in silico in silico analysis In silico method infected with SARS-CoV-2 inhibitor MAPK3 mechanism mechanism and characterization mitogen mitogen-activated protein kinase modulation molecular molecular docking molecular docking analysis Necrosis network network pharmacology pathway Patient pharmacologic (drug) therapy pharmacological PLAU Plumbagin Potential treatment prognostic proliferation Protein protein kinase respiratory Result risk SARS-CoV-2 Screen severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance survival rate target targets TNF Treatment Tumor tumor necrosis tumor necrosis factor Urokinase-Type Plasminogen Activator uterine
[DOI] 10.3389/fendo.2021.714909 PMC 바로가기 [Article Type] Endocrinology

He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic Study

Pharmacology

Published on 2021-06-182022-10-31
Journal: Frontiers in Pharmacology
[Category] COVID-19,

[키워드] acute respiratory distress acute respiratory distress syndrome adjuvant Analysis ARDS Bupleurum can be used CCL2 Chinese Clinical efficacy Clinical practice combination therapy component composed conducted coronavirus disease Coronavirus disease 2019 COVID-19 Cytoscape Decoction Effect endothelial Fever GeneCard Glycyrrhiza uralensis growth factor he-jie-shen-shi decoction IL1B Inflammatory response inheritance inhibiting viral replication involved KEGG Kyoto Ligand Lung injury Man MAPK MAPK signaling MAPK3 mechanism mechanisms Medicine monotherapy Necrosis Negative conversion network network pharmacology nine notable nucleic acid oxidative stress p53 pathway Pathways Patient Pharmacology Pinellia ternata Potential PPI predict Protein Protein–protein interaction PTGS2 receptor required Result retrospective cohort study screened Scutellaria baicalensis selected severe COVID-19 shown suggested syndrome System T cell receptor target TCMSP therapeutic therapy TNF Toll-like receptor Tongji Hospital TP53 Traditional Traditional Chinese medicine treat Vascular VEGF VEGFA Wuhan
[DOI] 10.3389/fphar.2021.700498 PMC 바로가기 [Article Type] Pharmacology

The mechanism and active compounds of semen armeniacae amarum treating coronavirus disease 2019 based on network pharmacology and molecular docking

Original Article

Published on 2021-02-042022-10-31
Journal: Food & Nutrition Research
[Category] COVID-19,

[키워드] 3CLpro ACE2 amygdalin AutoDock binding activity biological processes caspase-3 cellular component Chinese Clinical practice collected component Compound coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Cytoscape database DAVID disease Disease network dissemination docking Effect EGFR eight endothelial enrichment analysis enzyme II epidermal GeneCards growth factor HRAS IL6 immunofluorescence indicated Inflammatory Injury Interaction KEGG Kyoto lung Lung inflammation MAPK MAPK1 MAPK3 mechanism mice modulating molecular docking molecular functions molecular mechanism network analysis network pharmacology nine objective OMIM Ontology outbreak pathway Pathways PPI Prevent protease Protein PubChem database public health receptor regulated Result retrieved SARS-CoV-2 Semen semen armeniacae amarum significantly increased SRC suggested target target prediction TCM TCMSP threat Transcription treated treating COVID-19 Treatment TTD Vascular VEGF VEGFA virus was used Western blot analysis
[DOI] 10.29219/fnr.v65.5623 PMC 바로가기 [Article Type] Original Article

In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesis

Research Article

Published on 2020-11-112022-10-31
Journal: Computational and Structural Biotechnology Journal
[Category] COVID-19,

[키워드] Abstract AKT1 Analysis approach ARDS Cancer candidate cascades Cell changes Coagulation coagulation cascade complement Complication computational analysis COVID-19 Critical Critical case Cytokines storm degranulation degree downstream driver expression Fold change Gene ontology globe host proteins Huh7 IFN-I in silico in vitro in vitro study include Infection inhibit intravascular coagulation IRAK1 IRF3 IRF7 ISG ITGAM KEGG pathway analysis knowledge lack MAPK signaling MAPK1 MAPK1/MAPK3 MAPK3 MAVS mechanism medical intervention mitigate MOST neutrophil degranulation overlap pathway Pathways PD-L1 platelet activation predicted Protein proteomic public health emergency receptor signaling Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe COVID-19 patients Signaling signaling pathway similarity Spread SRC STOM therapeutic targeting thrombosis thrombotic TNF TP53 Traf6 Transcriptome up-regulated VAMP8 viral infection viral pathogenesis
[DOI] 10.1016/j.csbj.2020.11.005 PMC 바로가기 [Article Type] Research Article