Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in miceArticle Published on 2022-11-022022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] Activation Arm cellular COVID-19 disease demonstrated development disease Efficacy hamster humoral IgA immune Immunity immunization induce intramuscular intramuscularly intranasal intranasally Lower respiratory tract lung Lung pathology medical need memory B cell mice mucosal mucosal immune pandemic promote protective immunity public health rapid progress response resulting robust S-2P Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Seroconversion Spike protein systemic immune response the SARS-CoV-2 Transmission unique upper respiratory tract Vaccine vaccine candidate variants viral clearance weight loss while [DOI] 10.1371/journal.pone.0272594 PMC 바로가기
SARS-CoV-2-Naïve Korean Children and Adolescents Hospitalized With COVID-19 in 2021Article Published on 2022-10-312022-11-16 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome adjusted odds ratio Adolescent Affect children clinical manifestation conditions coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity Critical evaluated had no hospital Hospitalization Hospitalized Illness severity Isolation Korean less Medical conditions medical need Mild moderate multicenter obesity outcome Patient Pneumonia proportion respiratory Retrospective study risk risk factor SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity South Korea vaccination against COVID-19 variant with COVID-19 [DOI] 10.3346/jkms.2022.37.e303 PMC 바로가기
Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19Research article Published on 2022-10-012022-10-05 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] acute respiratory syndrome Antiviral antiviral activity Antiviral treatment B.1.351 B.1.617.2 Beta Brequinar cellular Combination coronavirus coronavirus disease COVID-19 de novo deaths Delta DHODH Dihydroorotate dehydrogenase (DHODH) Dipyridamole drug treatments effective enzyme evade Evolution of SARS-CoV-2 exhibit global pandemic Host host cell in vitro Infection infections inhibitor maintain medical need monoclonal antibody nucleotide pathway rationale Replication required resulting RNA virus SARS-CoV-2 SARS-COV-2 infection selective shown Support synergistic therapy treat Treatment Vaccine variants viral replication [DOI] 10.1016/j.antiviral.2022.105403 [Article Type] Research article
Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial Research Published on 2022-08-112022-10-05 Journal: Nature Medicine [Category] 임상, [키워드] CETP CETP inhibitor cholesteryl ester Combination Concentration Course double-blind Effect HDL-C include inhibitor LDL-C limitations Lipid lipoprotein cholesterol Low-Density Lipoprotein cholesterol management median medical need outcome outcomes over Patient patients phase 2 trial Placebo placebo-controlled trial Protein Randomized safety profile significant decrease significantly statin Support tested therapy transfer Treatment Trial [DOI] 10.1038/s41591-022-01936-7 [Article Type] Research
Protection of hamsters challenged with SARS-CoV-2 after two doses of MVC-COV1901 vaccine followed by a single intranasal booster with nanoemulsion adjuvanted S-2P vaccineMVC-COV1901 백신 2회 접종 후 SARS-CoV-2에 감염된 햄스터 보호 및 나노에멀젼 보조제 S-2P 백신이 포함된 단일 비강 내 부스터Article Published on 2022-07-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] alum booster booster vaccination country COVID-19 COVID-19 vaccine COVID-19 vaccines CpG1018 death Delta disease dose elicit followed by hamster Hospitalization Immunity immunization immunogenicity Infection intramuscular intranasal Lung pathology medical need mucosal offer omicron Pandemics Patient prefusion problem promote protection protective immunity protocol reduced regimen respiratory respiratory tracts resurgence robust S-2P SARS-CoV-2 SARS-CoV-2 spike severe COVID-19 severe disease solution Transmission vaccination Vaccine variants variants of SARS-CoV-2 Viral viral challenge viral clearance viral infection waning immunity weight loss were used [DOI] 10.1038/s41598-022-15238-y PMC 바로가기 [Article Type] Article
Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trialControlled Clinical Trial Published on 2022-06-282022-10-05 Journal: Journal of Translational Medicine [Category] 임상, [키워드] age American Anhydrous Anhydrous enol oxaloacetate approved average baseline book Chalder Fatigue Score chronic chronic fatigue syndrome Control Controlled clinical trial COVID COVID fatigue COVID patient Covid patients Diagnosis dosage dose enrolled evaluated face fatigue Hypothesis Intervention Long Long COVID main outcome measure ME/CFS ME/CFS clinical ME/CFS treatment media median age medical need Mental Meta-analysis non-randomized open label Oxaloacetate Patient patients physical Placebo Post viral fatigue. provided random reduced reduction in reductions in Registration reported scale Scoring Significant significantly Symptom tested TID Treatment Trial were given women [DOI] 10.1186/s12967-022-03488-3 PMC 바로가기 [Article Type] Controlled Clinical Trial
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulationArticle Published on 2022-06-012022-10-04 Journal: Photochemical & photobiological sciences : Official journal of the European [Category] COVID19(2023년), SARS, 신약개발, [키워드] amplification amplitude antimicrobial Antimicrobial photodynamic disinfection approved clinical sample Clinical use collected Concentration condition coronavirus disease COVID-19 COVID-19 patients cytotoxicity early stage exhibiting form global effort HEK293T cells infect Infection lentiviral luciferase reporter gene medical need Medicines Methylene Methylene blue nasal pandemic PDI photodisinfection photodynamic inactivation prevented pseudotyped Pseudotyped lentiviral vector reduce SARS-CoV-2 severity the disease the S protein Transmission Treatment urgency Viral load [DOI] 10.1007/s43630-022-00202-6 PMC 바로가기 [Article Type] Article
Early-stage Alzheimer disease: getting trial-ready Reviews Published on 2022-04-042022-10-05 Journal: Nature reviews. Neurology [Category] 바이오마커, 변종, 임상, [키워드] accelerate accelerated Alzheimer disease approval Asia Asymptomatic Biomarker Brain clinical trial Cohort collaboration determine disease effective Efficiency effort eligibility engage Europe example FDA individual initiated medical need Modification North America participant Participants performed progression randomize recruit recruitment required risk Stage study participant symptomatic the disease therapeutic therapeutic intervention therapy Trial trials [DOI] 10.1038/s41582-022-00645-6 [Article Type] Reviews
Was Alpha deadlier than wild-type COVID? Analysis in rural EnglandOriginal Paper Published on 2022-03-052022-10-29 Journal: Infection [Category] COVID-19, COVID19(2023년), MERS, SARS, 변종, [키워드] age Alpha variant Analysis B.1.1.7 calculated Case fatality rate case fatality rates conducted COVID-19 Deceased Deprivation diagnosed Diagnosis disease outbreak dominant England English Epidemiology Factors First wave less Logistic regression Male sex Marginal median age medical need Mortality mortality rate mortality risk multivariate observational study pandemic positive potential risk Probability raised Result risk Risk factors SARS-CoV-2 SARS-CoV-2 variant second wave Sex supplementary material tested variant was performed wild-type [DOI] 10.1007/s15010-022-01787-x PMC 바로가기 [Article Type] Original Paper
Rolling Reviews During COVID-19: The European Union Experience in a Global ContextCovid-19의 롤링 리뷰 : 글로벌 맥락에서 유럽 연합 경험Article Published on 2022-03-012022-08-31 Journal: Clinical therapeutics [Category] MERS, 신약개발, [키워드] accelerate added addressed applied approach approval approved as required benefit capture collected complement conducted Context COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines critical condition disease dynamic regulatory assessment effective Efficiency EMA European European Medicines Agency example expedited approval pathways experience faster focus globe Health authority health emergency help indicate information Intensive learning life-threatening literature medical need not limited offered Other pandemic Patient Regulatory required resource review Rolling rolling review Society submitted the vaccine the vaccines Treatment union unmet need Unmet Needs Vaccine Vaccines website [DOI] 10.1016/j.clinthera.2022.01.001 PMC 바로가기 [Article Type] Article