Enhanced anti-malarial efficacy of mefloquine delivered via cationic liposome in a murine model of experimental cerebral malariaarticle Published on 2024-04-302024-09-01 Journal: European Journal of Pharmaceutics and Biopharmaceutics [Category] 말라리아, [키워드] drug delivery Liposome malaria mefloquine Nanocarriers [Article Type] article
The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label usearticle Published on 2023-10-312024-09-05 Journal: Parasites & Vectors [Category] update2024, [키워드] Acedapsone albendazole amoxicillin Artemether artemisinins Arterolane artesunate Azithromycin azoles Balapiravir celgosivir Chloroquine clarithromycin Clavulanate CURE ID dapsone Diethylcarbamazine disulfiram doxycycline Drug reprofiling Drug repurposing fluconazole Imatinib Isavuconazonium itraconazole Ivermectin ketoconazole Levamisole Lumefantrine Mebendazole mefloquine Moxidectin moxifloxacin Neglected topical diseases nitazoxanide off-label use Oxamniquine Oxantel Piperaquine Posaconazole Praziquantel Pyrantel pamoate ravuconazole ribavirin rifampicin Rifapentine Sparfloxacin streptomycin Tribendimidine UV-4B [DOI] 10.1186/s13071-023-05909-8 PMC 바로가기 [Article Type] article
Suspected Mefloquine Toxicity in a Colony of Humboldt Penguins (Spheniscus humboldti)Article Published on 2023-03-312024-09-09 Journal: J Avian Med Surg [Category] 말라리아, [키워드] Avian drug toxicity Humboldt penguin Malaria prophylaxis mefloquine Plasmodium Spheniscus humboldti PMC 바로가기
Potential anti-mpox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatmentsArticle Published on 2023-03-092023-06-10 Journal: The Journal of Infectious Diseases [Category] 원숭이두창, [키워드] Antiviral atovaquone dihydroorotate dehydrogenase mefloquine molnupiravir mpox pan-Orthopoxvirus. [DOI] 10.1093/infdis/jiad058
Curcumin modulates multiple cell death, matrix metalloproteinase activation and cardiac protein release in susceptible and resistant Plasmodium berghei-infected micearticle Published on 2022-02-282024-09-01 Journal: Biomedicine & Pharmacotherapy [Category] 말라리아, [키워드] cell death Curcumin Gelatinases mefloquine Mitochondria [Article Type] article
Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant CellsArticle Published on 2022-02-112022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS, [키워드] accumulate Analysis anti-SARS-CoV-2 antimalarial antimalarial drug Antiviral approved drug assays Calu-3 Calu-3 cell Cell cell line Chloroquine clinical benefit clinical trials clinically concentrations COVID-19 differential expression example HCQ Human IL-6 in vitro in vitro activity information inhibit inhibited Interaction investigated lack Lungs mechanism of action mefloquine modulated monocyte Monocytes optimal dose parameter pathway pharmacological plasma predicted prevented reduced Respiratory Coronavirus respiratory diseases SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 replication SARS-CoV-2 RNA solidarity therapeutic therapy TMPRSS2-expressing cells TNF-α type II pneumocytes virus entry were assessed [DOI] 10.3390/v14020374 PMC 바로가기 [Article Type] Article
A Review of Modifications of Quinoline Antimalarials: Mefloquine and (hydroxy)Chloroquine퀴놀린 항말라리아제의 수정에 대한 검토: 메플로퀸 및 (하이드록시)클로로퀸Review Published on 2022-02-022024-08-08 Journal: Molecules [Category] 말라리아, [키워드] Chloroquine derivatization Hydroxychloroquine late-stage modification mefloquine quinoline Semisynthesis [DOI] 10.3390/molecules27031003 PMC 바로가기 [Article Type] Review
Mefloquine as a prophylaxis for malaria needs to be revisitedarticle Published on 2021-12-312024-09-01 Journal: International Journal for Parasitology: Drugs and Drug Resistance [Category] 말라리아, [키워드] malaria mefloquine Neuropsychiatric side effects [Article Type] article
Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitroMicrobiology Published on 2021-04-302022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] administration anti-malarial drug anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity antiviral activity antiviral potency approved calu-3 cells caused Cell cells Clinical efficacy Combined compounds Concentration coronavirus coronavirus 2 Coronavirus disease 2019 COVID-19 cumulative demonstrated dosage drug effective drug highest identify in vitro Infection inhibit inhibited inhibitor lung malaria mathematical mefloquine nelfinavir patients potent predicted Prevent public health reduce Replication reported repurposing respiratory SARS-CoV-2 screened severe acute respiratory syndrome-related coronavirus 2 standard treatment synergistic tested Treatment viral dynamics viral entry Viral load virus elimination [DOI] 10.3389/fmicb.2021.651403 PMC 바로가기 [Article Type] Microbiology
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infectionSARS-CoV-2 감염 억제제로서의 기존 의약품 및 한약의 식별422 Published on 2021-02-022022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 변종, 신약개발, 치료제, [키워드] 3CL addition Amino acid amino acid sequence animal models animals antibody Antiviral antiviral agent approved assays caused cell-based and animal studies Compound Concentration confirmed case COVID-19 death disease drug Drug administration Drug repurposing effective Efficacy enzymatic assay evaluate food Food and Drug Administration global pandemic glycosylated hamster hamsters herbal medicine herbal medicines Human identification in vitro in vivo Infection inhibitors of SARS-CoV-2 mefloquine Mentha molecular Mutation nelfinavir outbreak pandemic Perilla frutescen Perilla frutescens protease Remdesivir reported RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection Screen sequence Significance small molecule Small molecules Spike protein tested the disease Treatment Trimeric spike protein Vaccines variant Viral viral surface virus water [DOI] 10.1073/pnas.2021579118 PMC 바로가기 [Article Type] 422