A comparative recombination analysis of human coronaviruses and implications for the SARS-CoV-2 pandemicArticle Published on 2021-08-302022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] 229E Analysis breakpoint Computational biology and bioinformatics coronavirus CoV datasets detect displaying events Evidence Evolution Genes Genome genomic HCoV HKU1 human coronavirus immune evasion implication indicated involved Lineage MERS-CoV MERS-CoV genome moderate NL63 OC43 pandemic phylogenetics Phylogeny Recombination recombination event SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 recombination sequence skewed spike gene Surveillance the SARS-CoV-2 These data viral infection [DOI] 10.1038/s41598-021-96626-8 PMC 바로가기 [Article Type] Article
Comparative study: nonsynonymous and synonymous substitution of SARS-CoV-2, SARS-CoV, and MERS-CoV genomeOriginal Article Published on 2021-06-302022-11-01 Journal: Genomics & Informatics [Category] COVID-19, [키워드] acute respiratory syndrome Analysis analyzed Comparative coronavirus divergence time dN/dS Evolution favor Hypothesis indicate investigated likelihood MERS-CoV genome Middle East Neutral nonsynonymous nucleotide sequence positive proportion Respiratory syndrome respiratory syndrome coronavirus Result SARS-CoV SARS-CoV-2 significantly statistical strain Substitution Support syndrome synonymous synonymous and nonsynonymous change transition/transversion ratio Variation viruses [DOI] 10.5808/gi.20058 PMC 바로가기 [Article Type] Original Article
Limited Genetic Diversity Detected in Middle East Respiratory Syndrome-Related Coronavirus Variants Circulating in Dromedary Camels in JordanCommunication Published on 2021-03-312022-10-28 Journal: Viruses [Category] Coronavirus, Fulltext, [키워드] amplify Arabian Peninsula Camel circulating circulation coronavirus Coronaviruses Diversity Dromedary Endemic genetic diversity Genome sequence data greater Human Jordan Kingdom lack Limited Lineage MERS MERS-CoV MERS-CoV genome Middle East nasal swab nosocomial outbreak pathogen Phylogenomics population genomics Recombination reported respiratory resulting Saudi Arabia sensitivity sequence South Korea subsequent analysis TCID Transmission United Arab Emirate variant viral genomics zoonoses zoonotic [DOI] 10.3390/v13040592 PMC 바로가기 [Article Type] Communication
On the Prevalence and Potential Functionality of an Intrinsic Disorder in the MERS-CoV ProteomeArticle Published on 2021-02-222022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] 3D structure antibody approach binding caused complex contribute coronavirus disorder drug effective evaluate feature flexible function functional high mortality rate Host intrinsic intrinsically Intrinsically disordered proteins linear mechanism MERS-CoV MERS-CoV genome Middle East molecular MoRFs motifs organism Pathogenesis performed Potential Protein protein structure Proteins proteome regions severe respiratory illness SLiM Structural analysis Structure suggested syndrome Transmission Treatment Vaccine viral infection Viral protein virus [DOI] 10.3390/v13020339 PMC 바로가기 [Article Type] Article
A Half-Day Genome Sequencing Protocol for Middle East Respiratory Syndrome CoronavirusMicrobiology Published on 2021-02-192022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] amplified applied clinical sample Complete contribute coronavirus CoV CoV genome develop Diagnosis Epidemics Genome MERS MERS (middle east respiratory syndrome) MERS-CoV MERS-CoV genome Middle East MinION long-read sequencing Mutation outbreak Outbreaks PCR primer protocol public health recent respiratory Result sequence sequenced Sequencing serum samples syndrome universal primer variant Variation WGS whole genome whole-genome sequencing [DOI] 10.3389/fmicb.2021.602754 PMC 바로가기 [Article Type] Microbiology
Phylogenetic Analysis of MERS-CoV in a Camel Abattoir, Saudi Arabia, 2016–2018Research Letter Published on 2020-12-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] abattoir Camel Camels characterized clade coronavirus Dromedary full-length Lineage MERS MERS-CoV MERS-CoV genome Middle East Middle East respiratory syndrome Phylogeny respiratory infections respiratory syndrome coronavirus RNA Saudi Arabia tested virus viruses zoonoses [DOI] 10.3201/eid2612.191094 PMC 바로가기 [Article Type] Research Letter
Computational analysis of SARS-CoV-2, SARS-CoV, and MERS-CoV genome using MEGAOriginal Article Published on 2020-09-242022-11-01 Journal: Genomics & Informatics [Category] COVID-19, [키워드] acute respiratory syndrome Analysis average base Bayesian information criterion BIC Biotechnology center China coronavirus criterion Frequency Genetic Genetic variation genomic data highlight information likelihood lowest MERS-CoV MERS-CoV genome Middle East Middle East respiratory syndrome Molecular Evolutionary Genetic Analysis National Center for Biotechnology Information NCBI Novel coronavirus nucleotide nucleotide substitution pandemic percentages respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 Spread statistical analysis used to evaluate [DOI] 10.5808/GI.2020.18.3.e30 PMC 바로가기 [Article Type] Original Article
Prediction and Analysis of SARS-CoV-2-Targeting MicroRNA in Human Lung EpitheliumCommunication Published on 2020-08-262022-10-31 Journal: Genes [Category] COVID-19, [키워드] acute respiratory syndrome binding site cellular cellular antiviral defence coronavirus coronavirus disease Coronavirus infection COVID-19 differentially expressed epithelium Evidence expression expression profile Genome Human identify In vitro infection Infection infections low expression lung epithelia lung epithelial mechanism MERS-CoV genome microRNA pandemic pathogenic coronavirus predicted prediction PROTECT Research responsible RNA virus RNA viruses SARS-CoV SARS-CoV-2 susceptibility the SARS-CoV-2 genome tissue viral propagation [DOI] 10.3390/genes11091002 PMC 바로가기 [Article Type] Communication
Genomic Sequencing and Analysis of Eight Camel-Derived Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Isolates in Saudi ArabiaArticle Published on 2020-06-032022-10-28 Journal: Viruses [Category] COVID-19, [키워드] 2019-nCoV 3D structure Analysis Antibody binding appear B cell betacoronaviruses bioinformatics cause Clustering Complete contribute coronavirus Dromedary camel effective vaccine eight epitope evolutionary relationship exhibited Genome Gulf homology Host Human humans isolate MERS-CoV MERS-CoV genome Middle East Neutralizing antibodies occurred outbreak Phylogenetic analysis predict Region respiratory respiratory syndrome coronavirus SARS-CoV Saudi Arabia selected sequence sequenced severe respiratory illness spike glycoprotein Spike protein strain Strains Vaccine design virus [DOI] 10.3390/v12060611 PMC 바로가기 [Article Type] Article
Isolation and growth characterization of novel full length and deletion mutant human MERS-CoV strains from clinical specimens collected during 2015Short Communication Published on 2019-11-082022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, [키워드] caused characterized clade clinical isolates collected coronavirus CoV Deletion eight exhibited full length Genome genomic sequences growth growth kinetics Host HUH7 cells Human human infection independent isolate Lineage MERS MERS-CoV MERS-CoV genome Middle East Middle East respiratory syndrome human coronavirus mutant ORF1a ORF3 Patient performed Phylogenetic analysis Phylogeny plasticity Region replicated reported Saudi Arabia Sequencing specimen specimens strain syndrome Vero Vero cells viral isolates viral respiratory zoonotic [DOI] 10.1099/jgv.0.001334 PMC 바로가기 [Article Type] Short Communication