In Vitro Anti-SARS-CoV-2 Activity of Selected Metal Compounds and Potential Molecular Basis for Their Actions Based on Computational Study선택된 금속 화합물의 시험 관내 항 -SARS-COV-2 활성 및 계산 연구에 기초한 그들의 작용에 대한 잠재적 분자 기초Article Published on 2021-12-102022-09-10 Journal: Biomolecules [Category] SARS, 치료제, [키워드] Action activity antimony antimony trichloride Antiviral antiviral drugs antiviral property auranofin Basis calculation complex complexes Compound compounds COVID-19 cytotoxicity drug evidenced form gold implication in vitro initial metal metalation metallodrugs molecular basis nine notable nucleobase occur Potential residue ruthenium SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus tested the SARS-CoV-2 virus titanium Treatment treatment of COVID-19 trichloride viral infection [DOI] 10.3390/biom11121858 PMC 바로가기 [Article Type] Article
Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2Article Published on 2021-05-252022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activity Antiviral antivirals calu-3 cells complex complexes COVID-19 death display effective effective antiviral treatment evaluated global pandemic highlight in vitro metal metallodrugs organometallics SARS-CoV-2 Spread Stool Support Toxicity Treatment Vero E6 viral pathogen virucidal virus [DOI] 10.3390/v13060980 PMC 바로가기 [Article Type] Article
Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike‐ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics **코로나바이러스 단백질을 표적으로 하는 금 금속약물: Auranofin 및 금 유기금속에 의한 Spike-ACE2 상호작용 및 PLpro 프로테아제 활성에 대한 억제 효과 **Communication Published on 2020-10-192022-09-10 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] SARS, 치료제, [키워드] ACE2 activity acute respiratory syndrome angiotensin angiotensin converting enzyme anticancer antirheumatic antiviral drugs auranofin complexes coronavirus correlated drug target Effect effective inhibitor enzyme evaluated example FIVE gold gold complexes host receptor inhibitor inhibitors inhibitory effect Inhibitory effects Interaction interfere lead metallodrugs pilot study PLPro protease reported respiratory SARS-CoV-2 SARS‐CoV‐1 SARS‐CoV‐2 SARS‐CoV‐2 protein selected Spike protein target targets Viral viral entry process viral replication Zinc zinc ion zinc ions [DOI] 10.1002/chem.202004112 PMC 바로가기 [Article Type] Communication
A Structural Chemistry Perspective on the Antimalarial Properties of Thiosemicarbazone Metal Complexesarticle Published on 2019-12-312024-09-01 Journal: Mini-Reviews in Medicinal Chemistry [Category] 말라리아, [키워드] anti-Plasmodium drugs Antimalarial drugs drug mechanism of action heavy metal complexes metallodrugs structural chemistry of metal-thiosemicarbazones thiosemicarbazone metal complexes transition metal complexes. [Article Type] article