Plasmodium falciparum proteases as new drug targets with special focus on metalloproteasesarticle Published on 2024-06-302024-09-01 Journal: Molecular and Biochemical Parasitology [Category] 말라리아, [키워드] drug resistance inhibitors malaria metalloproteases Plasmodium falciparum Proteases [Article Type] article
Metalloprotease-Dependent S2′-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2Article Published on 2022-09-212022-11-16 Journal: Viruses [Category] SARS, 변종, [키워드] absence ACE2 ACE2 receptor assays benefit cell-cell fusion Combination contribute contributing to COVID-19 ectodomain Factor fusion in vitro induce inhibitor metalloproteases not reduce observation patients with COVID-19 pharmacological promote reduce SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant serine protease serine proteases significantly Spike protein syncytiation. the SARS-CoV-2 the spike protein treatment strategy [DOI] 10.3390/v14102094 PMC 바로가기
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoVStructural Biology Published on 2020-11-042022-10-31 Journal: Clinical Science (London, England : 1979) [Category] COVID-19, SARS, [키워드] ACE ACE inhibitor ACE2 acute respiratory syndrome Alzheimer’s dementia Analysis angiotensin converting enzyme angiotensin converting enzyme 2 blood pressure body fluid cardiovascular disease cleave coronavirus COVID-19 Cryo-electron microscopy disease fibrosis function functional highlight homologue Immunity Infectious disease insecticides Interaction involved Like Lineage mechanism mechanisms metalloproteases methodology obesity organism pandemic physiological provide RAAS receptor Regulation responsible SARS-CoV SARS-CoV-2 substrate therapy tissues Treatment turn understanding X-ray crystallography [DOI] 10.1042/CS20200899 PMC 바로가기 [Article Type] Structural Biology