Applicability of an active matrix metalloproteinase-8 point-of-care test in an oral and maxillofacial surgery clinic: a pilot studyOriginal Article Published on 2023-05-302024-09-05 Journal: Odontology [Category] update2024, [키워드] aMMP-8 Infection metalloproteinase Oral and maxillofacial surgery pilot study [DOI] 10.1007/s10266-023-00821-0 PMC 바로가기 [Article Type] Original Article
Prognostic value of von Willebrand factor and ADAMTS13 in patients with COVID-19: A systematic review and meta-analysisReview article Published on 2022-10-012022-10-05 Journal: Thrombosis research [Category] 바이오마커, 진단, [키워드] ADAMTS13 addition Admission Analysis analyzed Antigen cause cleaving Clinical outcome Coagulation Coagulopathy Cochrane Library cofactor coronavirus disease COVID-19 COVID-19 patient Critical database death deficiency defined Effect endothelial injury estimate fixed FVIII ICU immunothrombosis increase indicated intensive care involved Ligand Meta-analysis metalloproteinase Mortality motif no significant difference non-ICU non-survivor outcome outcomes Patient patients with COVID-19 performed plasma poor prognosis Prognosis protease Quantitative random Result risk SARS-CoV-2 searched severe disease course subgroup analysis survivor Survivors systematic review the Newcastle-Ottawa Scale variable von Willebrand factor vWF Web of Science [DOI] 10.1016/j.thromres.2022.08.017 [Article Type] Review article
Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike ProteinArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ADAM10 addition bind Cell cell death cell interaction cleavage cleaved complex condition contributed coronavirus SARS-CoV COVID-19 develop domain effective element endosomal pathway entry pathway evade furin furin cleavage motif highly pathogenic Host host protease human coronaviruses identify Immunity independent Infection infection mechanism inhibitor involved membrane membrane fusion metalloproteinase organ damage Pathogenesis pathogenesis of COVID-19 pathway Prevent priming provide required S1/S2 boundary S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selective sequence siRNAs Site spike Spread surface surface receptor syncytium formation the spike protein therapeutic agent therapeutic target Therapies TMPRSS2 unique vaccination variants virus entry virus variant [DOI] 10.1128/mbio.00519-22 PMC 바로가기
Neuro-Axonal Damage and Alteration of Blood-Brain Barrier Integrity in COVID-19 PatientsCOVID-19 환자의 신경-축삭 손상 및 혈액-뇌 장벽 무결성의 변경Article Published on 2022-08-102022-09-11 Journal: Cells [Category] SARS, 치료기술, [키워드] absence alteration ARDS ARDS patient ARDS patients barrier Biomarker Blood blood-brain barrier CNS COVID-19 COVID-19 patient COVID-19 patients CSF damage ddPCR detectable discharge disease severity enzyme healthy donor healthy donors Hospitalization integrity involved light chain long-COVID matrix matrix metalloproteinases metalloproteinase MMPs neuro-COVID neurofilament neurofilament light chain Neurological symptom Neurological symptoms NfL Patient plasma plasma samples SARS-CoV-2 RNA SARS-CoV-2 RNA detection Zinc zymography zymography. [DOI] 10.3390/cells11162480 PMC 바로가기 [Article Type] Article
An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse ModelADAM17 중화 항체는 COVID-19 마우스 모델에서 바이러스 부담을 증가시키면서 염증과 사망률을 감소시킵니다Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 ADAM17 ADAM19 adverse outcome Alter angiotensin anti-viral role antibody appear blockade blocked burden Cell cell entry receptor cellular activation cleave COVID-19 COVID-19 pathogenesis COVID-19 patients Critical ectodomain Increasing Inflammation Inflammatory inflammatory cascade K18-hACE2 less lung Lung pathology lung; metalloproteinase mice Model monoclonal antibody mouse mouse model pathway Proinflammatory cytokine promote protease Proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 viruses significantly increased significantly lower therapeutic TNF-α Transgenic mouse transmembrane viral burden virus while [DOI] 10.3389/fimmu.2022.918881 PMC 바로가기 [Article Type] Article
Genetic prediction of ICU hospitalization and mortality in COVID-19 patients using artificial neural networks인공신경망을 이용한 코로나19 환자 중환자실 입원 및 사망률의 유전적 예측Article Published on 2022-03-012022-09-11 Journal: Journal of Cellular and Molecular Medicine [Category] 변종, [키워드] absence ADAMTS13 age age and gender ANN artificial intelligence Artificial neural network C3a CD46 CD55 CFB CFD CFH CFHR1 CFI Clinical outcome clinical outcomes complement complement inhibition coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical death death in COVID-19 develop disintegrin dysregulation examined Gender Genes Genetic genetic susceptibility genetic susceptibility. Genetic variant genetic variants Hospitalization Hospitalized ICU identified variant identify metalloproteinase morbidity morbidity and mortality Mortality motif Next-generation sequencing outcome Patient patients phenotype presence or absence recruited SARS-CoV2 severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly increased THBD thrombomodulin Thrombospondin unmet need variant variants [DOI] 10.1111/jcmm.17098 PMC 바로가기 [Article Type] Article
SARS- CoV-2 infection and oxidative stress in early-onset preeclampsia조기 발병 자간전증에서 SARS-CoV-2 감염 및 산화 스트레스Review Published on 2022-03-012022-09-12 Journal: Biochimica et biophysica acta. Molecular basis of [Category] MERS, SARS, 진단, [키워드] Activation ADAM17 affected alteration alterations association cause Characteristics coronavirus disease COVID-19 Cytokine storm disease early-onset Endothelial dysfunction enzyme expressed expression Foetus Frequency functional highlight Human immune system infect infected with SARS-CoV-2 Infection Inflammation lung lung tissue mechanism mechanisms metalloproteinase oxidative stress Placenta placental preeclampsia Pregnancy pregnant women Preterm birth programming renin-angiotensin system reported SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection susceptibility tissue tissue damage Vascular virus with COVID-19 women worsening [DOI] 10.1016/j.bbadis.2021.166321 PMC 바로가기 [Article Type] Review
Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patientsCOVID-19 환자의 중증도 바이오마커로서의 기질 금속단백분해효소(MMP) 3 및 9Clinical Trial Published on 2022-01-242022-09-10 Journal: Scientific Reports [Category] 바이오마커, 임상, 진단, 치료법, [키워드] benefit Biomarker Biomarkers circulating neutrophil circulating neutrophils clinical heterogeneity contribute controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity disease severity Diseases Health Organization help Hospital admission Hospitalization hospitalized patient immunology inflammatory process interleukin-6 lung damage Lung inflammation matrix matrix metalloproteinases Medical research metalloproteinase MMP3 MMP9 molecular basis monocyte Monocytes myeloperoxidase Neutrophils no correlation occur pathogenic positively correlated Potential biomarker potential biomarkers predict progression Protein Proteins regeneration serum Serum level serum levels severe COVID-19 patient severe COVID-19 patients severe patients severity severity of COVID-19 significantly increased targeted therapy the WHO to define was increased was reduced WHO World Health Organization [DOI] 10.1038/s41598-021-04677-8 PMC 바로가기 [Article Type] Clinical Trial
Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza박테리아 동시 감염 및 지속적인 호중구 기관지 폐포 염증에 대한 비정형 반응은 인플루엔자와 중요한 COVID-19를 구별합니다Research Article Published on 2022-01-112022-09-12 Journal: JCI Insight [Category] 진단, 치료기술, [키워드] activating Antibiotic treatment Bacterial bacterial coinfections BAL BAL fluid blood sample bronchoalveolar Bronchoalveolar lavage CCL7 chemokine chemokines chemotactic factor circulating Cohort collected comparable Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients CXCL1 CXCL11 CXCL12 CXCL8 cytokine Cytokines decrease effector cell elafin elevated fluids G-CSF highlighting IL-1 β IL-17A IL-1ra Immunological response immunology Inflammation Influenza Invasive mechanical ventilation leukocyte lung Lungs Lymphocytes mechanically ventilated patient mechanically ventilated patients metalloproteinase Monocytes neutrophil neutrophilic Neutrophils NK cell NK cells parameter pathophysiology patients with COVID-19 patients with influenza Protease inhibitor protease inhibitors proteolytic activity severe coronavirus disease Tissue Inhibitor TNF- α Treatment Viral pneumonia [DOI] 10.1172/jci.insight.155055 PMC 바로가기 [Article Type] Research Article
Calcium Signaling Pathway Is Involved in the Shedding of ACE2 Catalytic Ectodomain: New Insights for Clinical and Therapeutic Applications of ACE2 for COVID-19Review Published on 2022-01-052022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] ACE2 ACE2 shedding acute respiratory syndrome ADAM17 aggravate airway epithelia all-cause mortality angiotensin-converting enzyme 2 application Betacoronavirus calcium Calcium signaling calmodulin catalytic clinical coronavirus COVID-19 COVID-19 thromboembolic events down-regulation ectodomain Endothelial dysfunction endotoxin entry receptor Evidence form Infection Inflammation inhibit SARS-CoV-2 insight involved Lung injury mechanism membrane metalloproteinase Mortality Neuropilin-1 New pathological change pathway plasma activity pro-inflammatory cytokine Prognosis Protein renin-angiotensin system reported resulting SARS-CoV-2 shedding shown soluble ACE2 soluble catalytic ectodomain of ACE2 Support therapeutic thrombotic TNFα transmembrane Treatment tumor necrosis factor-alpha type I viral entry Vitamin D [DOI] 10.3390/biom12010076 PMC 바로가기 [Article Type] Review