Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients입원 시 해당과정 부산물인 메틸글리옥살의 혈장 수준 상승은 ICU COVID-19 환자의 사망률에 대한 독립적인 바이오마커입니다Article Published on 2022-06-092022-09-11 Journal: Scientific Reports [Category] MERS, 바이오마커, 치료기술, 치료법, [키워드] Admission Biomarker Biomarkers byproduct Care correlated COVID-19 patient COVID-19 patients CRP death died elevated enzyme Evidence evidence of explained glutathione Glycolysis high risk ICU ICU patient ICU Patients identify IL-1β independent inflammation markers Logistic regression analysis management methylglyoxal monocyte Monocytes Mortality on admission Patient plasma Plasma levels predict provide regression analysis survived therapeutic These data TNF-α uninfected control Variability [DOI] 10.1038/s41598-022-12751-y PMC 바로가기 [Article Type] Article
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors새로운 당화 기반 치료제 - 글리옥살라제 1 유도제 및 글리옥살라제 1 억제제Review Published on 2022-02-232022-09-10 Journal: International Journal of Molecular Sciences [Category] 비임상, [키워드] Activation active against aging alleviate apoptotic appear Breast cancer breath cancer chemotherapy Cell cell line Chemotherapy clinical impact clinical trial clinically Combination Complication contribute correction diabetes dicarbonyl stress disease DNA double-blind dysfunction evaluated expression Glioblastoma glioblastoma multiforme Glo1 Glycation glyoxalase hesperetin IMPROVE in vitro in vivo inactivation Increased induce inducer inhibitor insulin insulin resistance low-grade inflammation malaria metabolism methylglyoxal mice multidrug-resistant National Cancer Institute obese outcome outcomes pathogenic Placebo placebo-controlled Protein Proteins prototype Randomized resveratrol SARS-CoV-2 small molecule spliceosome Stress subjects survival therapeutic therapy Treatment Tumor tumor cell line tumors type 2 diabete type 2 diabetes unfolded protein response Vascular [DOI] 10.3390/ijms23052453 PMC 바로가기 [Article Type] Review
Antiviral and Immunomodulatory Effects of Phytochemicals from Honey against COVID-19: Potential Mechanisms of Action and Future DirectionsReview Published on 2020-10-292022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV Action acute respiratory syndrome antiviral activity antiviral agent Antiviral agents Antiviral effect antiviral immune response antiviral immunity approved caffeic acid caused component Compound Coronavirus-2 COVID-19 COVID-19 outbreak described direction disease Effect effective Evidence Future global pandemic Honey knowledge lack mechanism methylglyoxal New coronavirus phytochemical Potential resulting SARS-CoV-2 severe respiratory illness shown Stress these compound Treatment Vaccines [DOI] 10.3390/molecules25215017 PMC 바로가기 [Article Type] Review
Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 InfectionPharmacology Published on 2020-10-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activated antiviral activity arginine residue arginine residues bioinformatics caused cellular Concentration conserved coronavirus COVID-19 COVID-19 disease cysteine residue domain domains Doxorubicin drug effective vaccine Efficacy Evidence examined expected functional global pandemic glyoxalase inactivation Infection interactions MERS metabolite methylglyoxal Modification oxidative paclitaxel physiological system predicted produced producing proteome proteomics Quantitative reactive reactive oxygen specy residue ROS SARS-CoV SARS-CoV-2 selective susceptible targets the SARS-CoV-2 the spike protein therapeutic therapy Toxicity Treatment virucidal vulnerability [DOI] 10.3389/fphar.2020.585408 PMC 바로가기 [Article Type] Pharmacology
Carbon Nanomaterials Based Electrochemical Sensors/Biosensors for the Sensitive Detection of Pharmaceutical and Biological CompoundsArticle Published on 2015-09-042024-09-02 Journal: Sensors (Basel, Switzerland) [Category] 대상포진, [키워드] acetaminophen buckypaper Glucose Graphene methylglyoxal NADH SWCNTs valacyclovir [DOI] 10.3390/s150922490 PMC 바로가기 [Article Type] Article
In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infectionArticle Published on 2015-01-012023-06-24 Journal: Archives of medical research [Category] 신종인플루엔자, [키워드] Anti-influenza viral drug Influenza virus Manuka honey methylglyoxal neuraminidase inhibitors Synergistic effect. [DOI] 10.1016/j.arcmed.2014.12.002