Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39Structure Report Published on 2024-07-292024-09-05 Journal: Journal of Structural Biology: X [Category] update2024, [키워드] crystal structure inhibitor methyltransferase [DOI] 10.1016/j.yjsbx.2024.100109 PMC 바로가기 [Article Type] Structure Report
Catechin-Induced changes in PODXL, DNMTs, and miRNA expression in Nalm6 cells: an integrated in silico and in vitro approachResearch Published on 2024-06-152024-09-05 Journal: BMC Complementary Medicine and Therapies [Category] update2024, [키워드] ALL And catechin docking MD simulation methyltransferase miRNAs PODXL [DOI] 10.1186/s12906-024-04521-2 PMC 바로가기 [Article Type] Research
Broad-spectrum small-molecule inhibitors targeting the SAM-binding site of flavivirus NS5 methyltransferaseArticle Published on 2023-07-212024-09-05 Journal: ACS Infectious Diseases [Category] update2024, [키워드] broad-spectrum flaviviruses High Throughput Screening methyltransferase NS5 [DOI] 10.1021/acsinfecdis.2c00571 PMC 바로가기 [Article Type] Article
A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferasesAntimicrobial Agents Published on 2023-05-052024-09-05 Journal: Emerging Microbes & Infections [Category] update2024, [키워드] High Throughput Screening inhibitor methyltransferase nsp14 SARS-CoV-2 [DOI] 10.1080/22221751.2023.2204164 PMC 바로가기 [Article Type] Antimicrobial Agents
Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2′-O-ribose methyltransferasesArticle Published on 2022-09-012022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 치료제, [키워드] AHCY Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral drug antivirals attenuation Concomitant COVID-19 COVID-19 treatments Drug screening DZNep enzyme Ex vivo exhibit functional Host host-directed hyperinflammation identify Immune escape immunomodulatory effect in silico in vitro in vivo independent Infection Inflammation inhibitor Interaction Lung fibrosis marker Methylation methyltransferase pathogen reduce SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Side effects Stage suppresse Treatment Viral RNA virus replication [DOI] 10.15252/embj.2022111608 PMC 바로가기
In silico identification and validation of natural antiviral compounds as potential inhibitors of SARS-CoV-2 methyltransferaseSARS-CoV-2 메틸트랜스퍼라제의 잠재적 억제제로서의 천연 항바이러스 화합물의 실리코(in silico) 식별 및 검증Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] Coronavirus, SARS, 치료제, [키워드] acute respiratory syndrome coronavirus amentoflavone Analysis analyzed Antiviral agents Antiviral compounds Antiviral natural compounds approach baicalin binding mechanism caused complex Compound coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment Daidzin docking Effect In silico methods indicated inhibit inhibitor inhibitors of SARS-CoV-2 Interaction MD simulation methyltransferase molecular molecular docking molecular dynamic simulation molecular dynamics Molecular dynamics simulation MTase natural antiviral Novel coronavirus novel coronavirus disease offer outbreak parameter Probability resource respiratory SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stability Substitution the SARS-CoV-2 therapeutic Therapeutics these compound these compounds Trajectories treat Treatment treatment of COVID-19 unavailability vaccination Virtual screening was performed [DOI] 10.1080/07391102.2021.1886174 PMC 바로가기 [Article Type] Article
Identification and Inhibition of the Druggable Allosteric Site of SARS-CoV-2 NSP10/NSP16 Methyltransferase through Computational Approaches컴퓨터 접근을 통한 SARS-CoV-2 NSP10/NSP16 메틸트랜스퍼라제의 약물 가능 알로스테릭 부위의 식별 및 억제Article Published on 2022-08-172022-09-11 Journal: Molecules [Category] SARS, 변종, [키워드] affected allosteric site antagonistic action assessment binding free energy caused complexes Compound COVID-19 COVID-19 pandemic Drug discovery drug library effort enzyme evaluated exhibited Health Host identification Infectious virus inhibition inhibitor inhibitors life life cycle methyl transferase methyltransferase molecular molecular docking molecular dynamics Molecular dynamics simulation molecular interaction Perspective proliferation PROTECT Research robust SARS-CoV-2 SARS-CoV-2 life cycle screened Simulation Site stability target the SARS-CoV-2 these compound these compounds variants Viral RNA was performed [DOI] 10.3390/molecules27165241 PMC 바로가기 [Article Type] Article
Inhibition of Hepatitis E Virus Replication by Novel Inhibitor Targeting MethyltransferaseArticle Published on 2022-08-152023-06-11 Journal: Viruses [Category] E형 간염, Fulltext, [키워드] 3-(4-Hydroxyphenyl) propionic acid Antiviral hepatitis E virus HEV replication methyltransferase [DOI] 10.3390/v14081778 PMC 바로가기
The mechanism of RNA capping by SARS-CoV-2 Research Published on 2022-08-092022-10-05 Journal: Nature [Category] SARS, 유전자 메커니즘, [키워드] Analysis Antiviral complex COVID-19 domain exonuclease facilitate functional GDP genetics group Host immune Interaction mechanism methyltransferase N terminus nidovirus non-structural protein Nsp12 Nsp9 Nsps required residue RNA RNA genome SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA structures transfer translation treat Viral proteins [DOI] 10.1038/s41586-022-05185-z [Article Type] Research
Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activityArticle Published on 2022-08-042023-07-09 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), [키워드] coronavirus Methylation methyltransferase nsp10 nsp14 proof-reading SAH SARS-CoV-2 Structure XRD [DOI] 10.1016/j.str.2022.04.014 PMC 바로가기