SARS‐CoV‐2 spike spurs intestinal inflammation via VEGF production in enterocytesArticle Published on 2022-04-192023-06-15 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), MERS, SARS, [키워드] COVID‐19 digestive system GI symptoms intestinal inflammation Microbiology, Virology & Host Pathogen Interaction Vascular Biology & Angiogenesis vascular permeability VEGF [DOI] 10.15252/emmm.202114844 PMC 바로가기 [Article Type] Article
The return of the seasonal flu and cold Other diseases are set to rebound as Covid‐19 restrictions easeArticle Published on 2022-03-102023-06-17 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, [키워드] Economics, Law & Politics Microbiology, Virology & Host Pathogen Interaction Science Policy & Publishing [DOI] 10.15252/embr.202254932 PMC 바로가기
A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variantArticle Published on 2022-02-212023-06-16 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), MERS, SARS, [키워드] COVID‐19 inhalation K18‐hACE2‐transgenic mice Microbiology, Virology & Host Pathogen Interaction Pharmacology & Drug Discovery SARS‐CoV‐2 siRNA [DOI] 10.15252/emmm.202115298 PMC 바로가기 [Article Type] Article
High diversity in Delta variant across countries revealed by genome‐wide analysis of SARS‐CoV‐2 beyond the Spike protein스파이크 단백질을 넘어 SARS-CoV-2의 게놈 전체 분석에 의해 밝혀진 국가 간 Delta 변이체의 높은 다양성Article Published on 2022-02-142022-09-10 Journal: Molecular Systems Biology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Alpha Alpha variant Amino acid Analysis Beta Bioinformatics analysis contagious coronavirus country Delta delta variant dominant feature focus genomes highlight identify life list Microbiology, Virology & Host Pathogen Interaction Missense mutation Mutation mutations neutralization nucleocapsid other variant other variants pathogenic performed Prevalence prevalent prevalent strain Protein Proteins proteome public health reduced SARS‐CoV‐2 SARS‐CoV‐2 genome SARS‐CoV‐2 genomes SARS‐CoV‐2 protein SARS‐CoV‐2 proteins SARS‐CoV‐2 spike Spike protein susceptibility systematic analysis the Spike Transmissibility Vaccines Viral viral loads while [DOI] 10.15252/msb.202110673 PMC 바로가기 [Article Type] Article
Biparatopic nanobodies protect mice from lethal challenge with SARS‐CoV‐2 variants of concern2중 파라토프 나노바디는 우려되는 SARS-CoV-2 변종으로 인한 치명적인 공격으로부터 마우스를 보호합니다Article Published on 2021-12-202022-09-10 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta active against Analysis B.1 B.1.351 B.1.617.2 Beta cellular circulating circulating variant conserved COVID‐19 Delta Disease progression dose drug candidates effective epitope epitope mapping Epitopes generate high affinity human ACE‐2 mouse human ACE2 immunology in vitro in vivo increased survival Infection Inflammatory response intranasally lethal dose Lungs mice Microbiology, Virology & Host Pathogen Interaction Molecular Biology of Disease nanobodies nanobody neutralize Neutralizing neutralizing nanobodies pandemic Prevent PROTECT RBD receptor‐binding domain reduced SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 significantly Taking Therapeutics These data transgenic mice treat treated variants of concern variety Viral Viral load VoC VOCs [DOI] 10.15252/embr.202153865 PMC 바로가기 [Article Type] Article
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection바이러스 유래 마이크로 RNA는 SARS-CoV-2 감염 시 면역 반응 유전자를 표적으로 한다Article Published on 2021-12-162022-09-10 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3′UTR Argonaute conserved COVID‐19 COVID‐19 patients COVID‐19 cultured cells Dicer enzyme evade expression help Host Host immune response host immune responses host miRNA human cell identify immune response immune response gene immune response genes immune responses infected cell infected cells innate immune response interfere interferon interferon response isoform Microbiology, Virology & Host Pathogen Interaction microRNA miRNA miRNAs Nasopharyngeal swab nasopharyngeal swabs Patient predominant Proteins repress represse RNA Biology SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2 sequence small RNA Small RNAs target transcript Viral viral genome viral miRNA [DOI] 10.15252/embr.202154341 PMC 바로가기 [Article Type] Article
Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples감염성 예측: 임상 샘플에서 배양 가능한 SARS-CoV-2를 검출하기 위한 4가지 PCR 기반 분석 비교Article Published on 2021-12-132022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] addition analytical sensitivity caused Cell cell type clinical clinical sample clinical samples correlated COVID‐19 CPE Culture Cutoff Cytopathic effect dependent on detect diagnostic diagnostic testing effective expressing faster Genome identify infected individuals infectious Infectious virus Isolation Live virus Methods & Resources Microbiology, Virology & Host Pathogen Interaction negative‐strand pandemic parental predict replicative RNA RT‐PCR RT–PCR SARS‐CoV‐2 SARS‐CoV‐2 sgRNA significantly specimen subgenomic subset tested the cell TMRPSS2 transcriptional transcripts Vero E6 Vero E6 cell VERO E6 cells Viral Viral RNA viral RNA species viral RNA specy virus [DOI] 10.15252/emmm.202115290 PMC 바로가기 [Article Type] Article
Single‐cell transcriptomics identifies Gadd45b as a regulator of herpesvirus‐reactivating neuronsArticle Published on 2021-11-292024-09-04 Journal: EMBO Reports [Category] 대상포진, [키워드] GADD45B herpes simplex virus‐1 HSV‐1 Microbiology, Virology & Host Pathogen Interaction Signal transduction viral latency viral reactivation [DOI] 10.15252/embr.202153543 PMC 바로가기 [Article Type] Article
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody인간 항체에 의한 SARS-CoV-2의 보존된 취약성 사이트 발견Article Published on 2021-11-172022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 변종, 진단, [키워드] Affect Alpha antibody antiviral drugs attachment B.1.1.7 B.1.351 B.1.617.2 Beta characterized concern conserved convalescent Convalescent patients COVID‐19 patient COVID‐19 cross‐reactivity cross‐active neutralizing antibody Delta Delta variants destruction of spike electron microscopy engage epitope epitope distal escape mutants functional Gamma generate hamsters host cell host cell receptor mechanism Microbiology, Virology & Host Pathogen Interaction Microscopy monoclonal antibody MOST motif mutable mutants Mutation neutralization neutralize neutralized Neutralizing antibodies neutralizing antibody P.1 predicted RBD RBM receptor‐binding domain receptor‐binding domain reduce residue residues SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike spike Strains structural biology the RBD the Spike variants variants of concern Viral viral replication [DOI] 10.15252/emmm.202114544 PMC 바로가기 [Article Type] Article
Genome‐scale metabolic modeling reveals SARS‐CoV‐2‐induced metabolic changes and antiviral targets게놈 규모의 대사 모델링은 SARS-CoV-2 유도 대사 변화 및 항바이러스 표적을 보여줍니다Meta-Analysis Published on 2021-10-282022-09-10 Journal: Molecular Systems Biology [Category] MERS, SARS, 신약개발, 치료제, [키워드] acting Algorithm Analysis Antiviral antiviral target applied approach approved caused Cell cells change changes Combination Coronaviruses COVID‐19 dataset Drug repurposing effective facilitate GEM gene expression dataset Genetic genetic screen genome‐scale metabolic modeling Host identify medical need metabolic metabolism Microbiology, Virology & Host Pathogen Interaction pandemic Patient Pharmacology & Drug Discovery predict predicted provide Remdesivir reveal RNAi screen SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 virus SARS‐CoV‐2 siRNA target therapeutic option Vero E6 Viral viral proliferation [DOI] 10.15252/msb.202110260 PMC 바로가기 [Article Type] Meta-Analysis