The neurobiology of long COVIDReview Published on 2022-11-022023-07-10 Journal: Neuron [Category] COVID19(2023년), [키워드] astrocytes Autoimmunity blood-brain-barrier Cognitive impairment COVID-19 EBV hippocampal neurogenesis HSV Long COVID microglia Microvascular disease Myelin PAISs post-acute infection syndromes. SARS-CoV-2 [DOI] 10.1016/j.neuron.2022.10.006 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19Article Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accompanied acute respiratory syndrome astrocytes Brain cellular mechanism CNS coronavirus coronavirus disease COVID-19 CP: Microbiology CP: Neuroscience Diabetic exacerbated High-resolution induce infect Infection initial investigated macaque microglia Microscopy modulated molecular Neuroinflammation Neurological complication Neurological complications Neuron neuronal neurotropism NHP non-human primate model olfactory patients plethora provide reducing Region rhesus rhesus. robust SARS-CoV-2 systemic inflammatory response triggered [DOI] 10.1016/j.celrep.2022.111573 PMC 바로가기
Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine storm in COVID-19Review article Published on 2022-09-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, 치료제, [키워드] activated macrophage Activation administration adverse effect alleviate Brain Clinical management Clodronate COVID-19 COVID-19 vaccine COVID-19 vaccines Cytokine storm death depleting discharge dysregulation encapsulation event Factor Host immune response immunogenic reaction immunological induce Inflammation life-threatening Liposomal clodronate Liposome Macrophage microglia microglial microglial cell Mortality multiorgan failure new SARS-CoV-2 offer pathogenic phagocytic cell pharmacological positive proinflammatory public health reactive reported resulting SARS-CoV-2 infected individuals SARS-COV-2 infection therapeutic strategy variant while [DOI] 10.1016/j.medidd.2022.100136 [Article Type] Review article
Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19혈액-뇌장벽 기능 장애 및 SARS-CoV-2 감염에 대한 감수성에서 노화의 역할: COVID-19의 신경학적 증상에 대한 영향Review Published on 2022-08-182022-09-11 Journal: Fluids and Barriers of the CNS [Category] SARS, 치료기술, 치료제, [키워드] addition age aging alleviate astrocytes barrier blood-brain barrier Brain caused cell type Central nervous system cerebrospinal fluid CNS Comorbidity Corona Corona virus COVID-19 COVID-19 patients Cytokine storm deaths described diabete diabetes distress dysfunction endothelial cells endothelial function expression profile Hospitalization Impact inducer inflammatory reaction inflammatory reactions Interaction interactome microglia Mitochondria mitochondrial Mitochondrial function mitochondrial functions morbidity and mortality neurological Neurological symptom Neurological symptoms neurons Neurovascular outcome patients pericytes Pneumonia present respiratory respiratory distress risk factor role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus suggested susceptibility target therapy treat with COVID-19 [DOI] 10.1186/s12987-022-00357-5 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19코로나19 사망자의 SARS-CoV-2 뇌 부위 검출, 조직병리학, 유전자 발현 및 면역조절 변화Article Published on 2022-08-162022-09-11 Journal: Journal of neuropathology and experimental neurolo [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] Amygdala arising Autopsies Autopsy Blood Brain brains cerebellar cortex change Control COVID-19 COVID-19 cases cytokine Deafferentation detection Differentially expressed genes downregulation Encephalitis fraction Gene Expression Genes Hemorrhagic hemorrhagic encephalitis Histopathology immune immune response indicated involved marker microglia mucosa neuronal Non-COVID-19 olfactory olfactory bulb portal receptor reduced reduction Region Regional RNA polymerase RNA sequence RNA sequences RNA-dependent RNA polymerase RNAseq RT-PCR S gene SARS-CoV-2 SARS-CoV-2 E gene SARS-CoV-2. sequence serum Significant subject upregulation viral sequence virus with COVID-19 [DOI] 10.1093/jnen/nlac056 PMC 바로가기 [Article Type] Article
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulationArticle Published on 2022-07-072023-07-09 Journal: Cell [Category] COVID19(2023년), [키워드] Cognitive impairment COVID-19 H1N1 influenza hippocampal neurogenesis Long COVID microglia Myelin Neuroinflammation oligodendrocytes. [DOI] 10.1016/j.cell.2022.06.008 PMC 바로가기
Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing Research Published on 2022-06-302022-10-05 Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] abrupt onset Anxiety biological pathways CACNA1B candidate candidate gene categories category children Cohort conducted de novo Deleterious described disorder disrupting etiology European Evidence Exome expressed functional GABRG2 Genes Genetic variant Genetic variation GRIN2A heterogeneous identification immune functions Infection infections irritability microglia Mutation nervous system neuronal Neuropsychiatric NLRC4 pathological mechanism pediatric peripheral immune response PLCG2 PPM1D RAG1 regulate selected Sequencing SGCE SHANK3 Stressor subject swings Symptom syndrome SYNGAP1 union variant WES WGS whole genome [DOI] 10.1038/s41598-022-15279-3 [Article Type] Research
SARS-CoV-2 Infection of Microglia Elicits Proinflammatory Activation and Apoptotic Cell DeathArticle Published on 2022-06-292023-07-09 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] Apoptosis M1 polarization microglia Neuroinflammation. SARS-CoV-2 [DOI] 10.1128/spectrum.01091-22 PMC 바로가기
Neurological sequela and disruption of neuron-glia homeostasis in SARS-CoV-2 infectionSARS-CoV-2 감염에서 신경교세포 항상성의 신경학적 후유증 및 붕괴Review Published on 2022-06-152022-09-12 Journal: Neurobiology of disease [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Astrocyte autonomous Axon beta-coronavirus cause caused clinical presentation condition coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 patients Cytokine storm death Diagnosis effective therapy Extracellular vesicles facilitate homeostasis immune system IMPROVE indicate Infection Injury intubation knowledge long-lasting microglia mitigate molecular Multi-organ damage Neuroinflammation neurologic neurological Neuron occur Oligodendrocyte Oligodendrocyte. outcomes pandemic pathology Pathomechanism Patient potential therapeutic target Prevent Respiratory failure responsible RNA SARS-CoV-2 SARS-COV-2 infection Severe COVID-19 Infection single-stranded systemic inflammatory response tissue Treatment [DOI] 10.1016/j.nbd.2022.105715 PMC 바로가기 [Article Type] Review
Non-Productive Infection of Glial Cells with SARS-CoV-2 in Hamster Organotypic Cerebellar Slice CulturesArticle Published on 2022-06-032023-07-09 Journal: Viruses [Category] COVID19(2023년), [키워드] astrocytes Brain COVID-19 microglia Neuroinflammation organotypic culture. SARS-CoV-2 [DOI] 10.3390/v14061218 PMC 바로가기