Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modelingTopical Review Published on 2024-07-012024-09-05 Journal: Biofabrication [Category] update2024, [키워드] hemorrhagic fever viruses Microphysiological systems vasculotropic disease [DOI] 10.1088/1758-5090/ad4c0b PMC 바로가기 [Article Type] Topical Review
SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological systemCardiovascular Medicine Original Research Published on 2024-03-212024-09-05 Journal: Frontiers in Cardiovascular Medicine [Category] update2024, [키워드] COVID-19 Endothelial dysfunction hypercytokinemia Microphysiological systems Shear stress [DOI] 10.3389/fcvm.2024.1360364 PMC 바로가기 [Article Type] Cardiovascular Medicine Original Research
Harnessing the power of microphysiological systems for COVID-19 researchArticle Published on 2021-11-012023-07-02 Journal: Drug discovery today [Category] SARS, [키워드] 3Rs COVID-19 Microphysiological systems MPS SARS-CoV-2 [DOI] 10.1016/j.drudis.2021.06.020 PMC 바로가기
Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 TherapeuticsPharmacology Published on 2021-08-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] arrhythmia Arrhythmias Azithromycin cardiac Cardiomyocytes Clinical findings clinical measurement clinical trial clinically clinician Combination combined efficacy COVID-19 debate drug drug response Drug screening drugs effective effective drugs effort Emergency use authorization evaluate events Evidence FDA Frequency global efforts HCQ heart heart muscle Hospitalization hospitalized COVID-19 patients Hydroxychloroquine identify increase in induced pluripotent stem cells Microphysiological systems MPS muscle platform pluripotent stem cell polytherapy predict predicted prediction Premature QT interval QT prolongation reflected resource Safe SARS-CoV-2 SARS-CoV-2 pandemic significant increase System Therapeutics time-consuming tissue treat treated treatment for COVID-19 was measured while worsening [DOI] 10.3389/fphar.2021.684252 PMC 바로가기 [Article Type] Pharmacology
Emerging Approaches to Understanding Microvascular Endothelial Heterogeneity: A Roadmap for Developing Anti-Inflammatory TherapeuticsReview Published on 2021-07-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Affect alteration blood vessel bMFA cellular and molecular Developing differentially expressed endothelial barrier permeability Endothelial cell Endothelium expressed functional variation Hemostasis heterogeneity in vitro model in vivo Inflammation inflammatory disease inner layer intrinsic leukocyte leukocytes Microphysiological systems microvascular endothelial cells Morphological neutrophil recruitment organ organ damage organ-specific organs phenotypic protein kinase Cδ proteomics reactive oxygen specy regulate regulated Regulation RNA sequencing Sepsis systemic systemic inflammatory response Therapeutics transmigration understanding Variation Vascular endothelium [DOI] 10.3390/ijms22157770 PMC 바로가기 [Article Type] Review
Mechanisms of radiation-induced endothelium damage: Emerging models and technologiesReview article Published on 2021-05-012022-10-05 Journal: Radiotherapy and oncology : journal of the Europea [Category] 비임상, [키워드] Activation acute radiation syndrome Adherens junctions AJAdherens junctions alteration apoptotic pathways ARSAcute radiation syndrome Ataxia telangiectasia-mutated ATMAtaxia telangiectasia-mutated biomimetic microfluidic assay bMFAbiomimetic microfluidic assay cardiovascular disease cell interactions cellular and molecular Central nervous system CNSCentral Nervous System Critical CVDCardiovascular disease Damage-associated molecular patterns DAMPDamage-associated molecular patterns develop Developing dysfunction ECEndothelial cell endothelial Endothelial cell Endothelium exposure G-CSFgranulocyte-colony stimulating factor Gastrointestinal Geranylgeranylacetone GGAGeranylgeranylacetone GIGastrointestinal GM-CSFGranulocyte/Macrophage Colony Stimulating Factor granulocyte-colony stimulating factor Granulocyte/Macrophage Colony Stimulating Factor Human umbilical vein endothelial cells HUVECHuman umbilical vein endothelial cells ICAM-1Intercellular adhesion molecule 1 IL-1interleukin-1 in vitro model in vivo Inflammatory response Injury Intercellular adhesion molecule 1 interleukin-1 ionizing radiation IRionizing radiation JAK1Janus kinase 1 JAM-CJunctional adhesion molecule-C Janus kinase 1 Junctional adhesion molecule-C knowledge LETLinear energy transfer leukocyte Linear energy transfer M-CSFmacrophage colony-stimulating factor macrophage colony-stimulating factor major histocompatibility complex management Manganese-dependent superoxide dismutase mechanism Medical countermeasures MHCMajor Histocompatibility Complex Microphysiological systems MnSODManganese-dependent superoxide dismutase morbidity and mortality MPSMicrophysiological systems NETsNeutrophil Extracellular Traps Neutrophil extracellular traps nuclear organ damage organs oxygen radical PAFPlatelet activating factor PAI-1plasminogen activator inhibitor type 1 pathology PDGFplatelet-derived growth factor PKCδProtein Kinase C-delta plasminogen activator inhibitor type 1 platelet activating factor platelet-derived growth factor Prevent protease PROTECT Protein Kinase C-delta Radiation radiological Radiotherapy reactive oxygen species resulting ROSreactive oxygen species SRSStereotactic radiosurgery stereotactic radiosurgery TBItotal body irradiation TEERTransendothelial electrical resistance TGFβTransforming Growth Factor-Beta therapeutic thought thrombomodulin tight junctions tissue tissue damage tissue injury TJTight junctions TMthrombomodulin TNF-αtumor necrosis factor-α total body irradiation Transendothelial electrical resistance Transforming Growth Factor-Beta Treatment tumor necrosis factor-α TYK2Tyrosine Kinase 2 Tyrosine Kinase 2 Vascular damage WBCWhite blood cells Weapons of mass destruction White blood cells WMDWeapons of mass destruction [DOI] 10.1016/j.radonc.2021.02.007 [Article Type] Review article
Modeling the Human Body on Microfluidic ChipsReview article Published on 2021-02-102022-10-05 Journal: Trends in Biotechnology [Category] 비임상, [키워드] animal approach Body complex Culture disease disease modeling Drug discovery functional highlight homeostasis Human human disease in vitro in vitro model in vitro models limitation Microphysiological systems modeling multiple organ offer organ-on-chip pathophysiology Personalized medicine platform therapeutic tissue development toxicities translational [DOI] 10.1016/j.tibtech.2021.01.004 [Article Type] Review article
Engineered tissues and strategies to overcome challenges in drug developmentReview article Published on 2020-09-262022-10-05 Journal: Advanced drug delivery reviews [Category] 비임상, [키워드] approved bioengineering candidate cause complement current disease modeling drug candidate Drug development Efficacy exclusion criteria healthcare helping highlight human clinical trials human tissue identify improvement in vitro in vivo in vivo model limitation Microphysiological systems overcome parameter pharmacokinetic preclinical studies preclinical study predict reduce Research Stem cell engineering therapeutic tissue tissue engineering Toxicity [DOI] 10.1016/j.addr.2020.09.012 [Article Type] Review article
Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2Article Published on 2020-01-012023-07-05 Journal: ALTEX [Category] SARS, [키워드] brain organoids. COVID-19 immunohistochemistry Microphysiological systems NEUROLOGY neurotropism organoids SARS-CoV-2 [DOI] 10.14573/altex.2006111