microthrombi – Communicable Diseases Research

Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19

COVID-19에 대한 인간 면역 시스템(HIS) 인간화 마우스 모델(DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD)

Article

Published on 2022-11-302022-09-11
Journal: Human vaccines & immunotherapeutics
[Category] SARS, 유전자 메커니즘,

Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestations

Article

Published on 2022-10-012022-11-16
Journal: Pathology
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] Autopsy Brain calculated case sery CD8 Cell Central nervous system clinical clinical manifestation clinical manifestations correlated correlation COVID-19 described Encephalopathy fatal COVID-19 FIVE highest hospitalisation hypoxic IL-6 illness duration intensive care lesion lesions macrophage activation syndrome microglial microthrombi Neuroinflammation neurological Neurological symptoms neuropathology. no correlation one patient onset of symptoms parameter pathology Patient patients performed Pituitary proportion qRT-PCR quantification retrospective SARS-CoV-2 RNA severe COVID-19 patient systemic inflammation T-cell activation Two patient Vascular
[DOI] 10.1016/j.pathol.2022.03.006 PMC 바로가기

Fatal Form of COVID-19 in a Young Male Bodybuilder Anabolic Steroid Using: The First Autopsied Case

Article

Published on 2022-09-292022-11-15
Journal: Medicina
[Category] SARS, 진단,

Effectiveness and safety of fibrinolytic therapy in critically ill patients with COVID-19 with ARDS: protocol for a prospective meta-analysis

Article

Published on 2022-09-262022-11-16
Journal: BMJ Open
[Category] meta-analysis, SARS,

[키워드] acute respiratory distress anticoagulation ARDS bleeding disorder bleeding disorders & bleeding event clinical trial clinical trials Coagulopathies COVID-19 COVID-19 pandemic Critical care critical care. Critically ill patient Efficacy and safety eligibility criteria eligible Evidence fibrin deposit fibrinolytic FIVE Gas exchange identify IMPROVE include Intensive intensive & lung Meta-analysis microthrombi Mortality other organs outcome Oxygenation Patient patients patients with COVID-19 peer-reviewed performed PROSPERO protocol quantitative synthesis randomised controlled trial Registered Safety secondary outcome Standard of care syndrome therapy Trial ventilation/perfusion with COVID-19
[DOI] 10.1136/bmjopen-2022-063855 PMC 바로가기

Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity

상승된 Myl9는 SARS-CoV-2 유발 폐삼출성 혈관염에서 Myl9 함유 미세혈전을 반영하고 COVID-19 중증도를 예측합니다

Article

Published on 2022-08-162022-09-12
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), MERS, SARS, 진단,

Platelets in the NETworks interweaving inflammation and thrombosis

염증과 혈전을 뒤섞는 NETworks의 혈소판

Review

Published on 2022-08-012022-09-11
Journal: Frontiers in Immunology
[Category] 치료기술, 치료제,

[키워드] activate Bacterial Capillaries capillary characterized chemokine chemokines chromatin Clinical outcome Coagulation factors contribute contributing to Course COVID-19 COVID-19 pandemic COVID-19 patient Cytokine storm disease DNA engage ENhance Evidence expression Extracellular extracellular space Growth factors hemorrhage Hemostasis histone Histones host innate immunity immune response immunothrombosis IMPROVE increased mortality induce infiltration Inflammation Inflammatory diseases inflammatory signaling Interaction interface kill lesion lung majority mechanism microthrombi molecular mechanism NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil infiltration Neutrophils other tissue other tissues pathogen Pathogens Pathways Patient Pattern recognition Pattern recognition receptors Platelet Platelets platelets. procoagulant Protein Proteins provide provided resulting signaling pathway subsequent surface expression survival target thrombi thrombosis thrombotic TLR2 TLR4 Topic TRAP Treatment vascular beds virus
[DOI] 10.3389/fimmu.2022.953129 PMC 바로가기 [Article Type] Review

Neurovascular injury with complement activation and inflammation in COVID-19

COVID-19에서 보체 활성화 및 염증으로 인한 신경 혈관 손상

Article

Published on 2022-07-292022-09-12
Journal: Brain : a journal of neurology
[Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] accompanied Activation acute respiratory syndrome adherent aggregate aggregation analysis Analysis astrogliosis autopsy study B cell Brain CD4+ T cell CD8+ T cells cellular change changes in characterized classical complement complement deposition Complement pathway complexes coronavirus coronavirus disease COVID-19 cytotoxicity determine died Endothelial cell First wave hindbrain humoral immune response immune complex immunohistochemistry Infection Inflammation Injury Macrophage mechanism microthrombi Neuroinflammation neurological manifestation neuronal Neurovascular neurovascular injury. nodule pandemic pathological change pathology pathophysiological mechanisms Patient patients died performed perivascular Platelet Platelets Post-mortem predominant Quantitative regions SARS-CoV-2 Serum protein short duration Vascular Vascular damage vascular leakage widespread
[DOI] 10.1093/brain/awac151 PMC 바로가기 [Article Type] Article

Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Observational Study

Published on 2022-06-012022-10-05
Journal: Critical Care Medicine
[Category] 임상,

[키워드] acute respiratory syndrome age anticoagulation assessment Biomarkers body mass index buffer clot Coagulation Cohort Comorbidities contribute coronavirus coronavirus 2 COVID-19 COVID-19 patient Critically ill patient cross-sectional determine died failure fibrin clot fluorescent functional Gender ICU ICU admission ICU patient Ill implication Infection interquartile range Laboratory measurement median microthrombi Mortality outcome Patient patients with COVID-19 patients without COVID-19 plasma positively correlated reported required respiratory Sepsis SOFA SOFA score Structure was collected was used widespread with COVID-19
[DOI] 10.1097/CCM.0000000000005465 PMC 바로가기 [Article Type] Observational Study

ACE2 protein expression in lung tissues of severe COVID-19 infection

중증 코비드 -19 감염의 폐 조직에서의 ACE2 단백질 발현

Article

Published on 2022-03-082022-09-01
Journal: Scientific Reports
[Category] MERS, SARS, 바이오마커, 진단, 치료기술,

[키워드] ACE2 ACE2 expression ACE2 protein acute lung injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen Biomarkers bronchopneumonia CD163 cells Complication controls Coronavirus-2 Correlation analysis COVID-19 COVID-19 disease DAD died Diffuse alveolar damage disease severity Diseases enzyme expression Histomorphology host protein Hypothesis hypothesised IHC immunohistochemistry immunostaining increased expression increased risk indications lung Lung injury lung tissue Macrophage Macrophage infiltration macrophages Medical research microthrombi Molecular biology non-COVID-19 patient Non-COVID-19 patients Pathogenesis Patient performed Platelet positively correlated post-mortem lung Protein protein expression random respiratory Risk factors Sample size SARS-CoV-2 SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 severe COVID-19 disease Severe COVID-19 Infection Severe infection significantly higher subset tested tissue Viral Virus Disease was performed were used
[DOI] 10.1038/s41598-022-07918-6 PMC 바로가기 [Article Type] Article

Multiphysics and multiscale modeling of microthrombosis in COVID-19

Research Article

Published on 2022-03-072022-10-28
Journal: PLoS Computational Biology
[Category] COVID-19, MERS, SARS,