COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and MicrothrombosisArticle Published on 2022-10-042022-11-15 Journal: Cells [Category] COVID19(2023년), SARS, 진단, [키워드] activated activated macrophages Activation age antibody Autopsy B-lymphocytes Brain change characteristic Clinical course controls COVID-19 COVID-19 case COVID-19 pathology elderly exhibited feature foci greater heart hearts highest Hyperactivation Inflammation Inflammatory kidney kidneys lung lung; Lymphocytes microglial Microthrombosis Neuropathology nine other tissue pathology pathophysiology PCR Platelets predominant role SARS-CoV-2 significantly significantly higher T-lymphocyte T-lymphocytes the disease tissue tissues viral antigens viral replication Viral RNA were used [DOI] 10.3390/cells11193124 PMC 바로가기
Cell tropism and viral clearance during SARS-CoV-2 lung infectionSARS-CoV-2 폐 감염 중 세포 친화성 및 바이러스 제거Article Published on 2022-08-012022-09-11 Journal: Pathology, research and practice [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Alpha alveolar macrophage Alveolar macrophages autopsy studies B.1.1.529 B.1.1.7 B.1.617.2 capillary microthrombosis caused Cellular target COVID-19 debate Delta detect driving Endothelial cell endothelial cells Endothelialitis epithelial cells fatal COVID-19 high viral load identify In situ hybridization infected cell key factor Lung infection lung tissue macrophages Microthrombosis omicron original virus strain Patient protein-coding RNA pulmonary reported RNA SARS-CoV-2 SARS-COV-2 infection severe COVID-19 spike Spike protein Time-course. variants variants of concern viral clearance viral infection Viral load Viral RNA was used [DOI] 10.1016/j.prp.2022.154000 PMC 바로가기 [Article Type] Article
Immunization with SARS-CoV-2 Nucleocapsid protein triggers a pulmonary immune response in ratsSARS-CoV-2 뉴클레오캡시드 단백질을 사용한 면역은 쥐에서 폐 면역 반응을 유발합니다Article Published on 2022-05-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] absence Activation administration affecting alteration animals anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody Asymptomatic biochemical can be used Clinical studies clinical study clinical symptom Clinical symptoms COVID-19 COVID-19 severity dead elicit emerging viruses Exacerbation groups histological histological analysis IgG antibodies immune response immunization immunological effect induce injection lead Local lung Microthrombosis multiple organ failure once a week Organ failure parameters produced Protein pulmonary immune response RATs Rattus Recombinant nucleocapsid protein recombinant proteins required Research respiratory insufficiency Safe SARS-CoV-2 SARS-CoV-2 pandemic sensitization Side effects Spread strain submitted Support synthesis Toxicity Trigger triggered vaccination Vaccine virus viruses world population [DOI] 10.1371/journal.pone.0268434 PMC 바로가기 [Article Type] Article
[Anticoagulation in coronavirus disease 2019 (COVID-19): confirmed and controversial aspects]Review Published on 2022-04-012023-07-08 Journal: Internist (Berl) [Category] COVID19(2023년), [키워드] COVID-19/prognosis fondaparinux heparin Microthrombosis Venous thrombosis [DOI] 10.1007/s00108-022-01296-x PMC 바로가기 [Article Type] Review
Pulmonary vascular inflammation with fatal coronavirus disease 2019 (COVID-19): possible role for the NLRP3 inflammasomeResearch Published on 2022-02-102022-10-28 Journal: Respiratory Research [Category] COVID-19, MERS, [키워드] accompany Activation acute respiratory disease affected appear ARDS caspase causes changes in component coronavirus disease COVID-19 disease distress expression H&E histological histopathological features hyperinflammation Inflammation Injury lung Lung inflammation Lungs Mechanical ventilation mechanical ventilation microthrombi Microthrombosis NLRP3 NLRP3 inflammasome Non-COVID-19 not different outcome pathway pulmonary response Result SARS-COV-2 infection shown subject subjects supplementary material syndrome thrombosis Treatment Vascular Vascular change Vascular endothelium vascular inflammation vessel wall vessels [DOI] 10.1186/s12931-022-01944-8 PMC 바로가기 [Article Type] Research
Strategies to minimize heterogeneity and optimize clinical trials in Acute Respiratory Distress Syndrome (ARDS): Insights from mathematical modelling급성 호흡 곤란 증후군(ARDS)에서 이질성을 최소화하고 임상 시험을 최적화하기 위한 전략: 수학적 모델링의 통찰력Article Published on 2022-01-012022-09-11 Journal: EBioMedicine [Category] 임상, [키워드] Action angiotensin approval baseline biologic Biomarker Biomarkers center Characteristics clinical response clinical responses clinical trial clinically Clustering complex interaction Corticosteroids COVID-19 Critical Critical care Critical illness Curie determined by Diabetic diabetic patients disease severity disparate driven by example expression foundation heterogeneity heterogeneity of treatment effect hyperinflamed hyperinflamed patient hyperinflamed patients identify IL6 immune response immunomodulation immunomodulatory Immunomodulatory therapies Immunosuppression individual Infection initiated Injury insight manuscript marker Mathematical modelling Microthrombosis Model modelling modulating neutrophil neutrophil recruitment NMF non-negative matrix factorization obese Older older patients outcome parameter Patient predict predicted Predictive Principal component principal component analysis RAS reduction Renin renin-angiotensin system representing Research respiratory respond responsible Strategy supported System System biology systemic cytokine Systems biology the disease therapy Treatment treatment initiation trials Trust [DOI] 10.1016/j.ebiom.2021.103809 PMC 바로가기 [Article Type] Article
Case Report: The Carotid Body in COVID-19: Histopathological and Virological Analyses of an Autopsy Case Series사례 보고서: COVID-19의 경동맥: 부검 사례 시리즈의 조직병리학적 및 바이러스학적 분석Case Reports Published on 2021-10-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] absence Affect aggregation Analysis angiotensin Angiotensin-converting enzyme Autopsy Blood Body carotid carotid body Cell cell types cells chain Chain Reaction chemosensitivity coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm demonstrated died Effect empirical evidence enzyme Evidence four subject four subjects histopathological histopathological finding histopathological findings immunohistochemistry immunostaining indirect effect indirect effects inflammatory reaction Invasion Local Lymphocytes male Microthrombosis molecular nervous system nucleocapsid peripheral arterial chemoreceptors polymerase chain reaction positive Protein reaction Real-Time Reverse Transcription Polymerase Chain Reaction reported respiratory RNA RT-PCR SARS-CoV-2 SARS-CoV2 Sery Severe acute respiratory syndrome silent hypoxia spike Spike protein T lymphocyte T lymphocytes type I Viral viral invasion Virological [DOI] 10.3389/fimmu.2021.736529 PMC 바로가기 [Article Type] Case Reports
Rapid Detection and Inhibition of SARS‐CoV‐2‐Spike Mutation‐Mediated MicrothrombosisResearch Article Published on 2021-10-232022-10-28 Journal: Advanced Science [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome adverse outcome age antibodies binding Blood Blood coagulation boost can be used coated with coronavirus coronavirus disease COVID‐19 patients D614G detection Endothelial cell enzyme examined genetic heterogeneity hACE2 Host immune response in viral increasingly Infection Inflammation inhibition Microfluidic chip Microthrombosis outcomes Patient patients platform presence of comorbidity protective mechanism Protein Rapid reduce reported Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike SARS‐CoV‐2 sequence spike tested therapy thought thrombosis thrombotic complication thrombotic event Thrombotic events vaccination Vaccine variant vector Whole blood [DOI] 10.1002/advs.202103266 PMC 바로가기 [Article Type] Research Article
Intermediate- vs. Standard-Dose Prophylactic Anticoagulation in Patients With COVID-19 Admitted in Medical Ward: A Propensity Score-Matched Cohort StudyMedicine Published on 2021-10-152022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Anticoagulant anticoagulation cohort of patient COVID-19 COVID-19 patient death evaluate the effect exclusion French Hospitalization Hospitalized In-hospital in-hospital mortality intermediate intermediate dose intermediate-dose group Kaplan–Meier LMWH Microthrombosis Mortality observé occurred Patient patients with COVID-19 Primary outcome Prophylactic prophylactic treatment reduction in regimen Retrospective study SARS-CoV-2 significant difference Standard dose Standard-dose statistically significant difference thrombosis thrombotic thrombotic event treated Treatment treatment group Trigger venous worsening [DOI] 10.3389/fmed.2021.747527 PMC 바로가기 [Article Type] Medicine
Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients폰 빌레브란트 인자와 ADAMTS13 축의 불균형은 코로나19 중환자에서 혈전 과정의 원인이라기보다는 오히려 강한 염증과 내피 손상의 바이오마커Article Published on 2021-09-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 바이오마커, [키워드] ADAMTS13 ADAMTS13 conformation Admission alveolar capillaries alveolar capillary Antigen Biological Biomarker Biomarkers Clinical features contribute coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients D-dimer deaths deficiency disintegrin driver Drivers elevated endothelial damage enrolled factor V fibrinogen hallmark hemolytic anemia hospital Imbalance Immune-mediated induce Inflammation Laboratory parameters male-to-female ratio median age microangiopathic hemolytic anemia microthrombi Microthrombosis Mortality open Patient patients Platelet Pulmonary embolism pulmonary embolisms purpura Quantitative reported Seven severe deficiency specificity thrombocytopenia thrombocytopenic purpura thrombotic thrombotic microangiopathy Thrombotic thrombocytopenic purpura type I von Willebrand factor vWF [DOI] 10.1111/jth.15445 PMC 바로가기 [Article Type] Article