The role and mechanisms of microvascular damage in the ischemic myocardiumReview Published on 2023-10-292024-09-05 Journal: Cellular and Molecular Life Sciences [Category] update2024, [키워드] Microvascular damage microvascular endothelial cells Microvascular leakage microvascular obstruction [DOI] 10.1007/s00018-023-04998-z PMC 바로가기 [Article Type] Review
Protection by metformin against severe Covid-19: An in-depth mechanistic analysisReview article Published on 2022-07-012022-10-05 Journal: Diabetes & metabolism [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Affect alleviate Analysis appear association cells COVID-19 death diabete disease fibrosis highlight immune response implicated in-depth analysis Inflammation mechanism metformin Microcirculation Microvascular damage multifactorial observation observational study outbreak outcome pathophysiological mechanism pathophysiology Patient pleiotropic Prevent progression PROTECT protection protective effect reported SARS-CoV-2 Spread target the cytokine storm Treatment type 2 diabete type 2 diabetes unique virus entry worsening [DOI] 10.1016/j.diabet.2022.101359 [Article Type] Review article
Elevated Cytokine Levels in Plasma of Patients with SARS-CoV-2 Do Not Contribute to Pulmonary Microvascular Endothelial PermeabilitySARS-CoV-2 환자의 혈장에서 증가된 사이토카인 수준은 폐 미세혈관 내피 투과성에 기여하지 않습니다Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] accounted ACE-2 receptor ACE2 antibody acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection angiopoietin antagonists antiinflammatory cytokines appear approach ARDS barrier dysfunction C3a C5a cause Cell changes in circulating Combination complement complements factors consecutive patient Control controls coronavirus cytokine Cytokines death demonstrated determine disrupt Effect eight Elevation endothelial Endothelial cell endothelial injury endothelial permeability enrolled evaluated Evidence evidence of Frequency greater growth factor heat inactivation human lung in vitro infections inhibitors labile Level lung magnitude mechanism Microvascular damage morbidity morbidity and mortality multiorgan failure Neutralizing antibodies neutralizing antibody occur patients patients hospitalized patients with SARS-CoV-2 permeability plasma positive control predicted produced proinflammatory cytokines provide pulmonary receptor receptor antagonists respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 plasma selected severe acute respiratory syndrome Coronavirus severe complication severe complications Spike protein subsequent susceptible syndrome the SARS-CoV-2 thrombin TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variability Vascular vascular endothelial growth factor Vascular injury vascular permeability VEGF [DOI] 10.1128/spectrum.01671-21 PMC 바로가기 [Article Type] Research Article
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular diseaseCardiovascular System & Vascular Biology Published on 2021-12-152022-10-31 Journal: Clinical Science (London, England : 1979) [Category] COVID-19, SARS, [키워드] ACE2 Activation acute respiratory syndrome alterations angiotensin converting enzyme 2 angiotensin-converting enzyme 2 antibody cause caused CD147 Cell cellular clinical response contributing to coronavirus COVID-19 death disease disrupt dysfunction elicited Endothelial cell events exposure to Extracellular Factor functional Hypothesis Implications in vitro induce infect infected patients Infection involved Ligand mechanism Microvascular damage Microvascular disease microvascular injury Migration mRNA neutralisation Patient pericyte Peripheral blood pro-apoptotic pro-inflammatory molecule Protein receptor recombinant S protein reduced rescued S protein SARS-CoV-2 secretion spike Spike protein stimulate Stress Support tested the cytokine storm the S protein the SARS-CoV-2 therapeutic variant Vascular wildtype [DOI] 10.1042/CS20210735 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology
COVID ‐19: Histopathological correlates of imaging patterns on chest computed tomographyCOVID -19 : 흉부 컴퓨터 단층 촬영에서 영상 패턴의 조직 병리학 적 상관 관계Original Article Published on 2021-06-222022-09-01 Journal: Respirology (Carlton, Vic.) [Category] MERS, 진단, [키워드] acute respiratory distress syndrome alveolar damage Autopsy bronchopneumonia cause causes Chest Chest computed tomography Chest CT clinical manifestation clinical manifestations Cohort Combination Computed tomography consolidation contribute coronavirus disease Coronavirus disease 2019 correlated correlation COVID COVID‐19 COVID‐19 DAD death Diffuse alveolar damage dominant editorial eight Evidence explain explained FIVE GGO histological histopathological histopathological and imaging histopathological finding histopathological findings lung lung parenchyma Microvascular damage Patient patients Pneumonia pulmonary area pulmonary computed tomography radiological radiological finding regions Result SARS‐CoV‐2, viral infection selected Seven Stage substrate thrombosis tissue Vascular damage while [DOI] 10.1111/resp.14101 PMC 바로가기 [Article Type] Original Article
Ophthalmic manifestations associated with SARS-CoV-2 in newborn infants: a preliminary report신생아에서 SARS-CoV-2와 관련된 안과 증상: 예비 보고서Case Reports Published on 2021-04-012022-09-11 Journal: Journal of AAPOS : the official publication of the [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect boxcarring caused children coronavirus COVID-19 edema Fluorescein fluorescein angiography Fundus examination hemorrhage Hemorrhagic hemorrhagic conjunctivitis hyperfluorescence infections laminar flow manifestation manifested Microvascular damage Newborn ophthalmic patchy Patient peripapillary preliminary report respiratory tract SARS-CoV-2 severe acute respiratory syndrome Coronavirus slit-lamp venous virus vitreous [DOI] 10.1016/j.jaapos.2020.11.007 PMC 바로가기 [Article Type] Case Reports
Pathological Findings in COVID-19 as a Tool to Define SARS-CoV-2 Pathogenesis. A Systematic ReviewPharmacology Published on 2021-04-012022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Abstract Activation Analysis article Autopsy Brain conducted consequence COVID-19 COVID-19 pandemic DAD database death develop Diagnosis Diffuse alveolar damage Effect Evidence excluded finding health emergency help hyperinflammatory state immune system immuno-thrombotic microangiopathy immunohistochemistry IMPROVE indicated Infection inflammatory cell inflammatory state investigated kidney knowledge liver lung massive Microscope Microvascular damage organs other organ other organs pathological pathological findings pathophysiological mechanism patients Post-mortem responsible review RT-PCR SARS-CoV-2 SARS-CoV-2 disease selected severe disease spleen systematic literature search systematic review therapy thrombotic tissue tissue damage tissue injury Vascular damage virus World Health Organization [DOI] 10.3389/fphar.2021.614586 PMC 바로가기 [Article Type] Pharmacology
Where There’s Smoke, There’s Fire: A Case Report of Turbulent Blood Flow in Lower Extremity Point-of-care Ultrasound in COVID-19COVID-19 Case Report Published on 2021-02-232022-10-31 Journal: Clinical Practice and Cases in Emergency Medicine [Category] COVID-19, [키워드] anticoagulation blood flow Coronavirus disease 2019 COVID-19 COVID-19 patient Deep venous thrombosis disease severity DVT endothelial injury Evidence extremity Flow high risk increased risk Inflammation Lower marker Microvascular damage pathology pathophysiological mechanisms Patient patients with COVID-19 Physicians Point-of-Care ultrasound predict proximal reactive report smoke Thromboembolism thrombosis Treatment Ultrasound venous Venous Thromboembolism vessel VTE [DOI] 10.5811/cpcem.2020.10.48809 PMC 바로가기 [Article Type] COVID-19 Case Report
SARS CoV‐2 related microvascular damage and symptoms during and after COVID‐19: Consequences of capillary transit‐time changes, tissue hypoxia and inflammationShort Review Published on 2021-02-012022-10-28 Journal: Physiological Reports [Category] COVID-19, MERS, [키워드] accelerate acute respiratory syndrome Affect Angiogenesis Anosmia Blood blood clot blood oxygen level Brain brain tissue breathlessness capillary dysfunction cause changes chest pain circulation Confusion consequence contribute Corona virus COVID‐19 COVID‐19 patient COVID‐19 symptom COVID‐19 Critical cytokine level delirium deteriorate diabetes diagnostic methods diffusion disease Effect elevated Endothelial cell Endotheliitis fatigue function Health heart hypertension Hypoxemia hypoxia identify Infection Inflammation instance limit long‐term symptoms Loss of Smell lung Lungs management memory Microcirculation Microvascular damage multiple organ muscle organ organs oxygen Oxygenation pericyte problem PROTECT rashes rehabilitation SARS‐CoV‐2 infection scar stimulate Symptom therapeutic tissue tissue damage tissue repair turn upstream Vascular vicious cycle virus weakness [DOI] 10.14814/phy2.14726 PMC 바로가기 [Article Type] Short Review
Proposal of the Definition for COVID-19-Associated CoagulopathyReview Published on 2021-01-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activated Activation adaptive caused clinical feature Coagulation Coagulopathy complement Complication COVID-19 COVID-19 patient Definition Disseminated intravascular coagulation Endothelial cell endotheliopathy event feature heparin Immunity include knowledge Laboratory large vessel lung mechanism Microvascular damage other organs pathological finding phenotype resulting similarity subject thrombotic thrombus formation up-regulated [DOI] 10.3390/jcm10020191 PMC 바로가기 [Article Type] Review