Computational Repurposing of Mitoxantrone-Related Structures against Monkeypox Virus: A Molecular Docking and 3D Pharmacophore StudyArticle Published on 2022-11-182023-06-09 Journal: International Journal of Molecular Sciences [Category] 원숭이두창, [키워드] Drug repurposing Epidemic in silico mitoxantrone molecular docking Monkeypox pharmacophore poxviruses Zoonotic. [DOI] 10.3390/ijms232214287 PMC 바로가기
A New Approach to Drug Repurposing with Two-Stage Prediction, Machine Learning, and Unsupervised Clustering of Gene Expression2 단계 예측, 기계 학습 및 유전자 발현의 감독되지 않은 클러스터링으로 약물 용도에 대한 새로운 접근 방식Article Published on 2022-06-012022-08-31 Journal: Omics : a journal of integrative biology [Category] MERS, 신약개발, 유전자 메커니즘, [키워드] Acetate affected alvocidib analyzed approach approximation big data bioinformatics BMS-387032 candidate Candidates characteristic clinical trial clinical trials Cluster Clusters Compound conditions Consistency Control COVID-19 pandemic Critical dermatomyositis develop dimension disease Diseases drug Drug development Drug discovery Drug efficacy Drug repurposing drug research and OMICS effective enrichment enrichment analysis examined expected expression pattern expression patterns followed by for inclusion function functions Gene Expression gene set enrichment analysis Health human diseases identify Inclusion Inclusion body inclusion body myositis Infectious disease Infectious diseases Innovation Intervention machine learning Machine learning. Manifold mitoxantrone myositis New offer pathway phorbol phorbol-12-myristate-13-acetate polymyositis prediction premise Probability projection repurposing Research reversed Reversibility targets Uniform variety vorinostat [DOI] 10.1089/omi.2022.0026 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid dropletsResearch Article Published on 2021-11-222022-10-31 Journal: Febs Letters [Category] COVID-19, [키워드] A549 A549 cell approach association biological processe blocked cancer cell Cancer cells cells droplet epithelial exhibited G3BP1 G3BP2 Heat shock human lung interact Interaction investigated liquid–liquid phase separation mitoxantrone N protein NCAP nucleocapsid nucleocapsid protein oxidative oxidative stress PKR Protein provide RNA RNA degradation RNase SARS‐CoV‐2 SARS‐CoV‐2 SILAC Stress stress granule stress granules translocated Treatment undergo USP10 viral factory viral infection YTHDF3 [DOI] 10.1002/1873-3468.14229 PMC 바로가기 [Article Type] Research Article
A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction텐서 분해 기반 비지도 특징 추출을 통한 신종 코로나바이러스(SARS-CoV-2)에 대한 새로운 첨단 in silico 약물 발견 방법Research Article Published on 2020-09-112022-08-13 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected alvocidib antiviral drug applied atorvastatin candidate canertinib cell line chloride clinical trial clinical trials Community Compound coronavirus costly COVID-19 Critical develop dibromochloromethane doxycycline drug drug candidate Drug discovery effective effective drug effective drugs experimental validation expression fluticasone gadolinium geldanamycin gene expression profile Gene expression profiles gentamicin identify in silico Ivermectin lung cancer meloxicam mitoxantrone motexafin gadolinium Novel coronavirus Numerous pandemic patients with COVID-19 quercetin radicicol respiratory SARS-CoV-2 Screen screened selected severe acute respiratory syndrome Coronavirus significantly sorafenib Tensor time-consuming treating COVID-19 trovafloxacin [DOI] 10.1371/journal.pone.0238907 PMC 바로가기 [Article Type] Research Article