MMP3 – Communicable Diseases Research

MMP3 in Severe COVID-19: A Biomarker or Therapeutic Target?

Article

Published on 2024-04-172024-09-05
Journal: Infectious disorders drug targets [Category] update2024,

[키워드] ARDS Biomarker MMP3 potential pharmacological target Respiratory failure therapeutic target
[DOI] 10.2174/1871526522666220619121539 PMC 바로가기 [Article Type] Article

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience [Category] 유전자 메커니즘,

[키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease
[DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article

Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patients

COVID-19 환자의 중증도 바이오마커로서의 기질 금속단백분해효소(MMP) 3 및 9

Clinical Trial

Published on 2022-01-242022-09-10
Journal: Scientific Reports [Category] 바이오마커, 임상, 진단, 치료법,

[키워드] benefit Biomarker Biomarkers circulating neutrophil circulating neutrophils clinical heterogeneity contribute controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity disease severity Diseases Health Organization help Hospital admission Hospitalization hospitalized patient immunology inflammatory process interleukin-6 lung damage Lung inflammation matrix matrix metalloproteinases Medical research metalloproteinase MMP3 MMP9 molecular basis monocyte Monocytes myeloperoxidase Neutrophils no correlation occur pathogenic positively correlated Potential biomarker potential biomarkers predict progression Protein Proteins regeneration serum Serum level serum levels severe COVID-19 patient severe COVID-19 patients severe patients severity severity of COVID-19 significantly increased targeted therapy the WHO to define was increased was reduced WHO World Health Organization
[DOI] 10.1038/s41598-021-04677-8 PMC 바로가기 [Article Type] Clinical Trial

Pharmacological Inhibition of MMP3 as a Potential Therapeutic Option for COVID-19 Associated Acute Respiratory Distress Syndrome

COVID-19 관련 급성 호흡 곤란 증후군에 대한 잠재적인 치료 옵션으로서 MMP3의 약리학적 억제

Article

Published on 2021-01-012022-09-11
Journal: Infectious disorders drug targets [Category] MERS, 바이오마커, 치료기술, 치료제,

[키워드] acute respiratory distress acute respiratory distress syndrome ARDS ARDS patient ARDS patients bacterial lipopolysaccharide Biomarker coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Early detection elevated high mortality inhibition Laboratory lipopolysaccharide matrix mediator mice MMP3 molecular mechanism molecular mechanisms option organ Patient plasma Potential Previous studies previous study progression reduce reduce mortality reported respiratory respiratory distress Respiratory distress syndrome severity stromelysin1 switch syndrome therapeutic treat virus infection
[DOI] 10.2174/1871526520666201116100310 PMC 바로가기 [Article Type] Article

Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19

COVID-19 환자를 위한 중요한 표지자로서의 기질 금속단백분해효소 3

Article

Published on 2021-01-012022-09-11
Journal: Journal of medical virology [Category] 바이오마커,

[키워드] analyzed biochemical center Chinese collected Concentration concentrations Control coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 COVID-19 patient Cytokines detect detection healthy individual IL-1β IL-6 Inflammation Inpatients interleukin marker matrix matrix metalloproteinase Medicine metalloproteinase MMP3 MMP3 concentrations Non-COVID-19 normality Novel coronavirus patients with COVID-19 Pneumonia positive correlation prevention Prevention and control proinflammatory cytokines sera serum Serum level serum levels Severity of disease situation SPSS statistically significant Therapeutic approach therapeutic approaches two group two groups university Wilcoxon rank sum Wilcoxon rank sum test
[DOI] 10.1002/jmv.26235 PMC 바로가기 [Article Type] Article