Remdesivir modifies interferon response in hospitalized COVID-19 patientsArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infection [Category] 치료제, [키워드] hospitalized COVID-19 patient interferon response modify [DOI] 10.1016/j.jinf.2022.07.021 PMC 바로가기
Hybrid Immunity Shifts the Fc-Effector Quality of SARS-CoV-2 mRNA Vaccine-Induced ImmunityArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accelerate antibody antibody function Antibody Response Antibody titer Antigen binding antibody Combination comparable conserved COVID-19 cross-reactivity disease dose expected Fc-receptors first dose function functional functions humoral immune response hybrid Hybrid immunity immune immune priming Immunity immunization immunodominance increases in indicate individual individuals Infection magnitude modify mRNA mRNA vaccination mRNA vaccine mRNA vaccines neutralizing antibody offer Quality receive recent Region remained resulting robust SARS-CoV-2 second dose selective serology shift spike subsequent symptomatic T cell the SARS-CoV-2 the Spike unique vaccination Vaccine vaccine-induced immune response vaccinee Vaccines variants of concern virus while [DOI] 10.1128/mbio.01647-22 PMC 바로가기
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1Article Published on 2022-10-182022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABCE1 abort acute respiratory syndrome affecting AKT Alzheimer’s disease autophagy biochemical analysis combating condition coronavirus COVID-19 pandemic Critical disease Diseases Drosophila effective exhibited Factors Genetic Host hosts mechanism modify neurodegenerative nonstructural protein 1 nsp1 overexpression pathogenic mechanism phenotype prevention Protein Quality control quality-control rescued Research ribosome collision ribosome-associated quality control. ribosomes SARS-CoV-2 Signaling specificity therapeutic strategy translation Treatment virus [DOI] 10.1073/pnas.2202322119 PMC 바로가기
HLA-C dysregulation as a possible mechanism of immune evasion in SARS-CoV-2 and other RNA-virus infectionsArticle Published on 2022-10-172022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alteration Analysis antigenic Cell cells changes in co-morbidities COVID-19 COVID-19 patient COVID-19 patients decrease DNA DNA methylation dysregulation enhancer enhancer transcriptional regulation evade expression Gene Expression gene expression profile genes encoding healthy controls HLA-C Host immune evasion immune response immune system implicated Infection inhibit Intervention involved mechanism memory response Methylation modify overlap Pathogens presenting Prognosis Prognostic marker Protein respiratory infection SARS-CoV-2 shown significantly symptomatic and asymptomatic symptomatic and asymptomatic COVID-19 T-cell therapeutic target transcriptional upper airway upper airways cells. viral antigens virus [DOI] 10.3389/fimmu.2022.1011829 PMC 바로가기
Coronavirus Host Genomics Study: South Africa (COVIGen-SA)Article Published on 2022-10-062022-11-15 Journal: Global health, epidemiology and genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] African black build coronavirus COVID-19 develop ENhance Factor female Genetic genetic information genome-wide association genomic Genomics genomics study Host Host genetic factor loci modify outcome over pandemic participant populations positive promote recruited Research resource risk factor SARS-CoV-2 Sequencing severe disease severity South South Africa susceptibility with COVID-19 with HIV [DOI] 10.1155/2022/7405349 PMC 바로가기
Numerical investigation on indoor environment decontamination after sneezing재채기 후 실내환경 오염제거 수치조사Article Published on 2022-10-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 변종, [키워드] accelerate ACh adopted affected air conditioning among others applied approach caused CFD change Characteristics Computational fluid dynamics Computational Fluid Dynamics (CFD) Conditioning coughs COVID-19 deaths decontamination deposition diffusion disease droplet droplets Dynamics escape Evaporation examined flow rate greater Heating high fidelity highest hospital hour HVAC systems injection less lung Lungs mechanism modify omicron over performed reduce risk room air Saliva SARS-CoV-2 significantly Simulation sneeze Sneeze droplets sneezes Spread Transmission variant Ventilation Ventilation effect virus virus spread virus transmission [DOI] 10.1016/j.envres.2022.113665 PMC 바로가기 [Article Type] Article
Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?Review article Published on 2022-10-012022-10-05 Journal: Environmental toxicology and pharmacology [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] Can Concentration Control copper correlated COVID-19 COVID-19 patients death rate deficiency dispersal exhibit facilitate host immune responses increase in independent risk factor Infection Inflammatory cytokine iron modify outcome oxidative stress Patient Prognosis prognostic regulate replication of SARS-CoV-2 risk of infections SARS-CoV-2 Selenium serum serum Cu levels severe COVID-19 significantly higher Spike protein suppress the SARS-CoV-2 viral genome viral replication while worse prognosis Zinc [DOI] 10.1016/j.etap.2022.103937 [Article Type] Review article
Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019Article Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] Activation acute respiratory syndrome addition Analysis and antibodies antibody C1q circulating classical classical pathway common cold common cold coronavirus common cold Coronaviruses complement complement system coronavirus coronavirus disease correlated COVID-19 Critical demonstrated develop disease disease severity greater healthy control hospitalized patient IgG response immune complex Immunoglobulin Immunoglobulin G implicated mechanism moderate modify outcome overactivation Pathogenesis Patient patients with COVID-19 plasma response responsible RNA SARS-CoV-2 severe COVID-19 severe patients severity systemically therapeutic strategy with COVID-19 [DOI] 10.1093/infdis/jiac091 PMC 바로가기
SARS-CoV-2 Spike mutations modify the interaction between virus Spike and human ACE2 receptorsSARS-CoV-2 스파이크 돌연변이는 바이러스 스파이크와 인간 ACE2 수용체 간의 상호 작용을 수정합니다Article Published on 2022-09-102022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding carried complex COVID-19 Effectiveness ENhance feature Health highest human ACE2 receptor Infection interact Interaction interface interface region Interface residues investigated modify molecular molecular interaction mutability Mutation mutations neutralization observé professional Protein question Repurposed drug Repurposed drugs researchers residue SARS-CoV-2 SARS-CoV-2 Spike mutation SARS-CoV-2 virus Scientific community severity significantly spike Spike protein spike-ACE2 stability the SARS-CoV-2 virus the Spike Vaccine virus Virus spike [DOI] 10.1016/j.bbrc.2022.06.064 PMC 바로가기 [Article Type] Article
Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1Article Published on 2022-09-082022-11-16 Journal: Molecules [Category] SARS, 변종, [키워드] accompanied Activation amino acid substitution BA.2.12.1 binding cathepsin G Cell cleavage site cleaved complex COVID-19 digested End furin immune response Infection MHC modify neutrophil Neutrophil elastase Neutrophils novel omicron Omicron variant Pathogens peptide polybasic Prevalence priming protease Protein proteinase proteinase 3 S1/S2 S2 antigen S2 subunit SARS-CoV-2 SARS-CoV-2 variant secrete sequence serine protease serine proteases Site Support T cell activation the major histocompatibility the S protein the Spike TMPRSS2 viral entry [DOI] 10.3390/molecules27185817 PMC 바로가기