SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19Article Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accompanied acute respiratory syndrome astrocytes Brain cellular mechanism CNS coronavirus coronavirus disease COVID-19 CP: Microbiology CP: Neuroscience Diabetic exacerbated High-resolution induce infect Infection initial investigated macaque microglia Microscopy modulated molecular Neuroinflammation Neurological complication Neurological complications Neuron neuronal neurotropism NHP non-human primate model olfactory patients plethora provide reducing Region rhesus rhesus. robust SARS-CoV-2 systemic inflammatory response triggered [DOI] 10.1016/j.celrep.2022.111573 PMC 바로가기
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기
Systems Bioinformatics Reveals Possible Relationship between COVID-19 and the Development of Neurological Diseases and Neuropsychiatric DisordersArticle Published on 2022-10-162022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Acidic acute respiratory syndrome Analysis app Autoimmunity bioinformatics biological processe Combination contribute coronavirus COVID-19 development disease disease-associated disorder disorders dysregulation epitope Epitopes genetic risk factor GFAp Host identify incidence include increased risk indicated Infection linear MAPT microtubule-associated protein modulated molecular molecular mimicry motif Multiple Myasthenia network biology neurodegenerative Neurodegenerative diseases neurological Neurological disease Neurological diseases Neurological disorder Neuropsychiatric neuropsychiatric disorders PPI precursor Protein protein-protein interaction Proteins receptors recognize relationship SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection sclerosis sequence similarity System systems bioinformatics. [DOI] 10.3390/v14102270 PMC 바로가기
A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin DArticle Published on 2022-10-142022-11-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Apoptosis changes in Chromatin structure contribute COVID-19 COVID-19 infections disease risk drug Effect Epigenetic epigenetic modification epigenetics Evidence Gene Expression Health help highlight Host immune response Immunity immunomodulatory effect indicate individual Infection Inflammation involved mechanisms Modification modulated multifunctional outcomes pathophysiology Prevent proliferation receptor receptor function reduced regulate SARS-CoV-2 target therapeutic therapeutic drug Treatment Vaccine viral outbreak virus Vitamin D while [DOI] 10.3390/ijms232012292 PMC 바로가기
Association of Midgut Bacteria and Their Metabolic Pathways with Zika Infection and Insecticide Resistance in Colombian Aedes aegypti PopulationsArticle Published on 2022-10-062022-11-16 Journal: Viruses [Category] 유전자 메커니즘, 치료기술, [키워드] ABC Aede Aedes aegypti affecting Analysis analyzed Bacteria Bacterial Bacteroide changes in Chikungunya Combination condition COVID-19 pandemic Defense Degradation disease Dysbiosis effective evaluated female females function functions generate Honda Host identify Infection infection control infection rate infections infective insecticide insecticides Interaction intestinal intestine knowledge lack lambda-cyhalothrin limitation Local management mechanism metabolic metabolism microbiota microcephaly midgut midgut. modulated Mutation natural infection outbreak pathogenicity Population populations predict predicted prenatal Pseudomona resistance risk RT-PCR significantly sodium South America Surveillance susceptibility susceptible syndrome Transmission Treatment Vaccine vector control Viral transmission virus entry was related Zika Zika virus ZIKV [DOI] 10.3390/v14102197 PMC 바로가기
Expanding the antiviral potential of the mosquito lipid-transfer protein AEG12 against SARS-CoV-2 using hydrophobic antiviral ligandsArticle Published on 2022-10-012022-11-15 Journal: Febs Letters [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral activity antiviral therapeutics bind Cell complexes Compound cytotoxicity drug delivery enveloped virus fatty Fatty acid hydrophobic inhibitors Ligand ligands lipid-binding protein mechanism membrane membrane disruption. membranes modulated neutralize Protein replaced resulting SARS-CoV-2 Therapeutic compounds unsaturated viruses [DOI] 10.1002/1873-3468.14456 PMC 바로가기
Sialic Acid and Fucose Residues on the SARS-CoV-2 Receptor-Binding Domain Modulate IgG Antibody ReactivityArticle Published on 2022-09-092022-11-15 Journal: ACS Infectious Diseases [Category] SARS, 진단, [키워드] acid antibody antibody reactivity carbohydrate cells Chinese hamster conserved defined domain embryonic kidney cell ENhance evaluated exhibited fucose generate glycoepitope glycoproteomics IgG less mammalian cells mass spectrometry modulated monosaccharides N-linked glycans Neutralizing antibodies produced Protein RBD reactivity Receptor binding domain reduced removal SARS-CoV-2 SARS-CoV-2 positive patients serum sample sialic acid Spike protein Structure the RBD the RBD protein the SARS-CoV-2 vaccine candidates Viral proteins [DOI] 10.1021/acsinfecdis.2c00155 PMC 바로가기
Nano-multilamellar lipid vesicles promote the induction of SARS-CoV-2 immune responses by a protein-based vaccine formulationArticle Published on 2022-09-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 진단, [키워드] Activation acute respiratory syndrome addition antibody Antigen C57BL/6 CD4 Complete conditions coronavirus COVID-19 demonstrated Diseases displaying dose effective hallmark highlight IgG immune response immunization in vitro in vivo Lipid-based nanoparticles mice modulated MPLA Nano-multilamellar vesicles promote Protein RBD Receptor binding domain reduced required responses Safe SARS-CoV-2 serum spike subunit Subunit vaccine T-cell Response T-cell responses toxic effect Vaccine Vaccines Vesicle virus-neutralizing antibody [DOI] 10.1016/j.nano.2022.102595 PMC 바로가기
Inhibition of SARS-CoV-2 main protease: a repurposing study that targets the dimer interface of the proteinSARS-CoV-2 주요 프로테아제의 억제: 단백질의 이량체 계면을 표적으로 하는 용도 변경 연구Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] binding energy catalytic dyad catalytically change characterized conformational coronavirus disease coronavirus disease-2019 COVID-19 crystal structure crystal structures Diosmin displaying Drug repurposing DrugBank database elicited eluxadoline Glu166 homodimer inhibition inhibitor inhibitors lethality rate Local M pro main protease modulated molecular molecular dynamics Molecular dynamics simulation molecular dynamics simulations novel target site. pandemic performed positive prominence Prophylaxis protease Protein reported residue SARS-CoV-2 Ser1 Simulation Spread target Therapeutics Trajectories trajectory Treatment Virtual screening Wuhan Wuhan, China Zinc [DOI] 10.1080/07391102.2021.1910571 PMC 바로가기 [Article Type] Article
Immune modulation as a consequence of SARS-CoV-2 infectionArticle Published on 2022-08-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] adaptive Alter alteration B cells CD3 CD8 Clinical severity clinically COVID-19 COVID-19 pathogenesis Cytokine storm D-dimer levels Decreased detrimental effects diagnosed elevated Elevation enrolled Frame healthy controls IFN-γ IgA level IgG IL-10 IL-6 IL-8 ILCs immune immune response Immunity Mild moderate modulated modulation negative correlation NK cell NK cells Patient Plasma cell pro-inflammatory cytokine Protective reduced reduction SARS-CoV-2 SARS-COV-2 infection Serum level severe COVID-19 disease Severe patient severe patients significantly subset T cell T cells the disease TNF-α [DOI] 10.3389/fimmu.2022.954391 PMC 바로가기