Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronavirusesArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis common cold Coronaviruses Compound COVID-19 COVID-19 therapeutics cytotoxicity effective gene expression profile globe Heat shock homoharringtonine host cell response host response in silico in vitro modulating other coronavirus pandemic pathway Prevent provided reported SARS-CoV-2 SARS-CoV-2 biology screened severe symptoms tanespimycin target tested unique Vaccine viral infection [DOI] 10.1038/s41598-022-21984-w PMC 바로가기
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
News from around the RNA world: new avenues in RNA biology, biotechnology and therapeutics from the 2022 SIBBM meetingArticle Published on 2022-10-152022-11-16 Journal: Biology open [Category] 유전자 메커니즘, [키워드] Biology Biophysics cell differentiation cellular Circular circular RNAs Community COVID19 disease DNA Dogma highlighting information International involved Italian modulating Molecular biology National New Non-coding RNAs, microRNAs Pandemics Protein provided RNA RNA therapies. RNAs Rome Society Stress Therapies therapy transcript translational [DOI] 10.1242/bio.059597 PMC 바로가기
Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular MechanismsArticle Published on 2022-10-142022-11-15 Journal: International Journal of Molecular Sciences [Category] 신약개발, 진단, [키워드] accompanied activity addition aging all-cause mortality animal model animal models available data benefit Biomarker blunt caloric restriction calories cardiovascular diseases Cardiovascular outcomes cellular senescence clinical study clinical trials Compound COVID-19 decrease diabetes driver drug drugs employment Evidence Fatty acid feature Glucose heart failure humans IL-6 independent inflammaging Inflammasome inhibitor inhibitors intrinsic Kidney disease low-grade inflammation Meta-analysis modulating modulation molecular Mortality nutrient-sensing pathways observational studies outcomes pathway Patient promote provided repurposing selected senescence sodium-glucose cotransporter 2 inhibitors. substrates suggested Support systemic effects systemic level target Urine [DOI] 10.3390/ijms232012325 PMC 바로가기
Targeted therapy in Coronavirus disease 2019 (COVID-19): Implication from cell and gene therapy to immunotherapy and vaccineReview article Published on 2022-10-012022-10-05 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 임상, 치료제, [키워드] acute respiratory syndrome affected antiviral agent approach approved caused Cell Cell based therapy characterized coronavirus coronavirus 2 Coronavirus disease 2019 Corticosteroids COVID-19 drug evaluated Gene therapy high risk highly pathogenic immune Immunotherapy in vitro in vivo Inflammatory Medical conditions modulating outcomes Oxygen therapy Patient Population SARS-CoV-2 syndrome targeted therapy therapeutic option therapy thrombosis Treatment Vaccine variety Vascular injury virus [DOI] 10.1016/j.intimp.2022.109161 [Article Type] Review article
Fermented natural product targeting gut microbiota regulate immunity and anti-inflammatory activity: A possible way to prevent COVID-19 in daily dietReview article Published on 2022-10-012022-10-05 Journal: Journal of Functional Foods [Category] 변종, 치료제, [키워드] Active substances Anti-inflammation Anti-inflammatory anti-inflammatory activity Bacteria change COVID-19 Effect gut microbiota immune function Immunity Inflammation Influenza ingredient lipid metabolism modulating molecular mechanisms natural products organs Prevent Probiotics regulate shifting shown viruses [DOI] 10.1016/j.jff.2022.105229 [Article Type] Review article
Urban Determinants of COVID-19 Spread: a Comparative Study across Three Cities in New York StateArticle Published on 2022-10-012022-11-16 Journal: Journal of Urban Health : Bulletin of the New York [Category] COVID19(2023년), SARS, 치료기술, [키워드] agent-based model city Comparative complex computational analysis conditions contribute COVID-19 deaths demographics determinant develop effective Efficacy epidemiologically Evidence favor hospital hospitals identifying immunization Infection initial modulating New New York outcome pandemic reduced Research question Resilient cities Spread spread of COVID-19 state underlie urban Urban design Urban design. vaccination [DOI] 10.1007/s11524-022-00623-9 PMC 바로가기
Response to SARS-CoV-2 vaccines in patients receiving B-cell modulating antibodies for renal autoimmune diseaseArticle Published on 2022-09-142022-11-15 Journal: BMC Infectious Diseases [Category] SARS, 진단, [키워드] Adequate anti-CD20 anti-CD20 treatment antibody antibody treatment Autoimmune disease B-cell B-cells CD19 CD20 cellular cellular response clinical correlated COVID-19 depleting develop disease generate humoral immune Immunity immunization kidney modulating Patient patients receiving treatment receiving regimens Registered renal response retrospective rituximab SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine single-center timespan Treatment vaccination vaccination response [DOI] 10.1186/s12879-022-07722-7 PMC 바로가기
Evaluation of the immunomodulatory effects of interleukin-10 on peripheral blood immune cells of COVID-19 patients: Implication for COVID-19 therapyArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] addition Analysis Antigen CD8 Cell Cohort Control controls COVID-19 COVID-19 patient cytokine downregulated Effect elevated ELISA enrolled evaluated expression FGF Flow cytometry analysis Frequency function GM-CSF highest HLA-DR Hospitalized IFN-γ IL-10 IL-2 IL-6 immune Immune cell immune factor immune factors immunomodulatory effect in vivo Infection Inflammation information investigated MCP-1 modulating multiplex Multiplex assay Natutal Killer Cells NK cells not affect Peripheral blood plasma platform producing provide reached reduce remained SARS-CoV-2 significantly spike stimulated subject survival T cell T-cell therapy TNF-α treated was collected were measured Whole-blood with COVID-19 [DOI] 10.3389/fimmu.2022.984098 PMC 바로가기
A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic optionsArticle Published on 2022-09-012022-11-16 Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘, [키워드] acetyl-CoA Activation alteration analyzed anti-inflammatory function CLYBL combating Control convert COVID-19 COVID-19 patients COVID-19 progression COVID-19 samples Critical Defense enzyme healthy controls Host host protein Human identify immune modulatory Immunity increase in Inflammation itaconate Macrophage metabolism metabolite moderate modulating observation pathway Pneumonia Protein proteome proteomes proteomic regulated RNA virus SARS-CoV-2 viruses severe symptom signaling pathway suggested TCA cycle the disease therapeutic option therapeutic target treating COVID-19 Urine worsening [DOI] 10.1007/s11427-021-2070-y PMC 바로가기