MAFB shapes human monocyte–derived macrophage response to SARS-CoV-2 and controls severe COVID-19 biomarker expressionResearch Article Published on 2023-12-222024-09-05 Journal: JCI Insight [Category] update2024, [키워드] Cellular immune response COVID-19 immunology macrophages Molecular pathology [DOI] 10.1172/jci.insight.172862 PMC 바로가기 [Article Type] Research Article
Real-world EGFR testing practices for non-small-cell lung cancer by thoracic pathology laboratories across Europearticle Published on 2023-09-142024-09-05 Journal: ESMO open [Category] update2024, [키워드] EGFR Europe Molecular pathology Non-small-cell lung cancer survey [DOI] 10.1016/j.esmoop.2023.101628 PMC 바로가기 [Article Type] article
Ethnicity, Comorbid Medical Conditions, and SARS-CoV-2 Test Cycle Thresholds in the Veteran PopulationArticle Published on 2022-10-012022-11-15 Journal: Journal of racial and ethnic health disparities [Category] COVID19(2023년), SARS, 진단, [키워드] access Access to health care addition Admission affected African American age Care center clinical Clinical course Clinical pathology collected COVID-19 COVID-19 infection cycle difference disease severity Ethnic groups Ethnicity Factors Gender Health ICU care increases in information Intensive Medical conditions Molecular pathology outcome Patient Philadelphia polymerase chain Population Population demographics positive public health Quality Quality assurance Quality control required Research retrospective RT-PCR SARS-CoV-2 SARS-CoV-2 RT-PCR test significantly statistically significant Test tested transcriptase veteran Viral load viral loads was performed [DOI] 10.1007/s40615-021-01114-4 PMC 바로가기
Lethal synergy between SARS-CoV-2 and Streptococcus pneumoniae in hACE2 mice and protective efficacy of vaccinationhACE2 마우스에서 SARS-CoV-2와 Streptococcus pneumoniae 간의 치명적인 시너지 효과와 예방 접종의 보호 효능Article Published on 2022-06-082022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, 폐렴구균 감염증, [키워드] alveolar approach Bacteria Bacterial Bacterial infections Combined Complication COVID-19 death dose effective Efficacy GM-CSF hACE2 IFNs immunology incidence Increased Infection Infectious disease Influenza lethal lung Lung inflammation Macrophage mice Molecular pathology mouse Mouse models murine occurred pathogen pathology pneumococcal infection pneumococci Protective reduced respiratory infection SARS-CoV-2 secondary Streptococcus pneumoniae subsequent survival synergistic synergy therapeutic targeting Treatment vaccination viral respiratory infections [DOI] 10.1172/jci.insight.159422 PMC 바로가기 [Article Type] Article
Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic reviewCOVID-19 환자의 구강 병변의 형태 및 조직 기반 분자 특성: 살아있는 체계적인 검토Review Published on 2022-04-012022-09-12 Journal: Archives of oral biology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age anatomical Cell Characteristics CMV COVID-19 COVID-19 pandemic epithelial Exocytosis FIVE identify individual Inflammatory item lesion LILACS male material molecular molecular data Molecular pathology molecular test Morphological oral oral pathology OVID Pandemics Patient performed reaction reported Reporting review SARS-CoV-2 SARS-CoV-2 spike protein searched systematic review the mean thrombosis vacuolization was performed Web of Science [DOI] 10.1016/j.archoralbio.2022.105374 PMC 바로가기 [Article Type] Review
Capturing a Crucial ‘Disorder-to-Order Transition’ at the Heart of the Coronavirus Molecular Pathology—Triggered by Highly Persistent, Interchangeable Salt-BridgesArticle Published on 2022-02-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anionic appear arginine baseline being binding catalytic cationic characteristic cleavage site coronavirus COVID-19 disorder disorder-to-order transition enthalpy entropy compensation entropy arrest events Evolution feature FLCS flexible furin cleavage Genome heart homologous Host increase in Interaction interactions Lineage Molecular pathology motif multiplicity offer persistent polybasic Protein proteolytic proteolytic cleavage residue respiratory viral diseases respiratory viruses S1/S2 junction salt-bridge salt-bridge dynamics SARS-CoV SARS-CoV-2 spike Spike–Furin interaction the SARS-CoV-2 Transmissibility [DOI] 10.3390/vaccines10020301 PMC 바로가기 [Article Type] Article
Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19중요한 COVID-19에서 심장 손상 및 미세 혈전에 대한 임상 조직 병리학 및 단일 핵 RNA 시퀀싱 통찰력Clinical Trial Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 임상, 진단, 치료기술, 치료제, [키워드] Acute cardiac injury Analysis antiplatelet association bioinformatics Biomarkers biomarkers of inflammation C-reactive protein cardiac injury Cardiology cardiovascular disease cause clinical factors Cohort conducted controls Corticosteroid corticosteroid treatment COVID-19 Critical enrichment erythrocyte sedimentation erythrocyte sedimentation rate etiology Extracellular matrix Features fibrinolysis fibroblast heart hearts identify In-hospital increased mortality Injury microthrombi Molecular pathology myocarditis Necrosis New York City pathophysiology Patient potential therapeutic target prevalent Prospective Study RNA-sequencing sedimentation rate Sequencing analysis Signaling tested therapeutic anticoagulation Therapies therapy transcriptomic were used [DOI] 10.1172/jci.insight.154633 PMC 바로가기 [Article Type] Clinical Trial
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations신장 오르가노이드 및 임상 인구에서 SARS-CoV-2 반응의 교차 검증Research Article Published on 2021-12-222022-09-10 Journal: JCI Insight [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Alpha ameliorated Apoptosis Beta blocked Cell cell types Clinical data comparable COVID-19 Critical Critically ill Critically ill patient critically ill patients Cross-validation feature gene expression pattern gene expression patterns Genetic diseases infect Infection interferon interferon pathway iPS cells Kidney disease kidney infection kidney organoid kidneys mechanism Molecular pathology morphology Nephrology organ Organoid organoids peptides polycystic kidney polycystic kidney disease Population populations proteomic proximal proximal tubules reflect reflected replicating virus response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral susceptibility target organs Therapeutics Therapies Treatment tropism upregulation Urine variant Viral viral fitness [DOI] 10.1172/jci.insight.154882 PMC 바로가기 [Article Type] Research Article
COVID-19 Transcriptomic Atlas: A Comprehensive Analysis of COVID-19 Related Transcriptomics DatasetsGenetics Published on 2021-12-222022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] anti-viral drug approach atlas bioinformatics Biomarker carried clinical setting clinical settings Comprehensive conditions confounding factor COVID-19 COVID-19 research database dataset datasets DEGs develop differentially expressed gene differentially expressed gene analysis disease severity explain expressed expressed gene Factor faster Gene Expression Gene Expression Omnibus generate GEO help human tissue identify increase in marker material molecular basis Molecular pathology omics analyses pathology Patient R software required Research retrieved SARS – CoV – 2 selected target the disease tissue transcriptomic transcriptomic data Vaccines [DOI] 10.3389/fgene.2021.755222 PMC 바로가기 [Article Type] Genetics
Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19Chitinase 3-like-1은 COVID-19에서 노화의 영향을 매개하는 치료 표적입니다Research Article Published on 2021-11-082022-09-10 Journal: JCI Insight [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] abrogate ACE2 aging angiotensin angiotensin converting enzyme caused CHI3L1 chitinase circulating comorbid disease comorbid diseases contributing to COVID-19 COVID-19 severity Critical Effect enzyme events Human Immunotherapy Infection inhibitor inhibitors investigated kasugamycin mechanism Molecular pathology Pathogenesis Patient Phosphorylation prevalent priming protease receptor SARS-CoV-2 severity Spike protein therapeutic target Therapeutics Viral viral spike protein with COVID-19 [DOI] 10.1172/jci.insight.148749 PMC 바로가기 [Article Type] Research Article