The progress of molecules and strategies for the treatment of HBV infectionReview Published on 2023-03-152023-06-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] B형 간염, [키워드] HBV HBV life cycle inhibitors molecules Treatment [DOI] 10.3389/fcimb.2023.1128807 PMC 바로가기 [Article Type] Review
Delivery of Antibody-Like Molecules, Monobodies, Capable of Binding with SARS-CoV-2 Virus Nucleocapsid Protein, into Target CellsArticle Published on 2022-10-012022-11-15 Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 진단, [키워드] antibody-like molecules C-terminus cellular cellular thermal shift assay delivery demonstrated E. coli expressed fluorescent fused HEK293T cell highest affinity Interaction molecules monobody nucleocapsid nucleocapsid protein penetration peptide Previous studies produced Protein replacement resulting S10 shuttle peptide SARS-CoV-2 selected significantly target target cells TAT TAT peptide the SARS-CoV-2 thermophoresis transfected with [DOI] 10.1134/S1607672922050088 PMC 바로가기
Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications Therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle [DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review
In Silico Repurposed Drugs against Monkeypox Virus원숭이 수두 바이러스에 대한 In Silico 재활용 약물Article Published on 2022-08-182022-09-11 Journal: Molecules [Category] Fulltext, 변종, 신약개발, 원숭이두창, [키워드] approved binding caused COVID-19 pandemic demonstrated disease drug Drug repurposing Epidemic Europe FDA food in silico in viral incidence molecular molecular dynamics molecules Monkeypox Mutation outbreak poxvirus poxviruses poxviruses. predicted Protein Replication Research spread to suppress tecovirimat Treatment US Food and Drug Administration variants Viral proteins viral replication Virtual screening virus [DOI] 10.3390/molecules27165277 PMC 바로가기 [Article Type] Article
Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces스파이크 단백질/ACE2 인터페이스를 조절하여 SARS-CoV-2 세포 진입의 새로운 억제제로서 비스-인돌릴 피리딘 및 트리페닐아민 선택Article Published on 2022-08-162022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, [키워드] 50% effective concentration ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus approaches association biochemical caused Cell cell lines cellular cellular receptor circulating circulating variant complex Compound coronavirus coronavirus disease COVID COVID-19 docking drug functional human cell lines identify in silico indicate Infection infectious agent inhibit inhibitor inhibitory inhibitory effect Interaction interface Lentiviral vector lentiviral vectors modulating molecular molecules New pandemic parameter pseudotyped pyridine receptor ACE2 S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 strain screened selected Selection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike susceptible the SARS-CoV-2 the Spike therapeutic purposes these compound these compounds triphenylamine variant viral entry viral infection viral replication virus wild-type [DOI] 10.1128/aac.00083-22 PMC 바로가기 [Article Type] Article
Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity주산기 인간 면역결핍 바이러스에 감염된 청소년 및 젊은 성인은 뚜렷한 BNT162b2 메신저 RNA 코로나바이러스 질병 2019 백신 면역원성을 나타냅니다.Article Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adolescent anti-SARS-CoV-2 humoral antibody Antigen Antigen-specific T cells Antiretroviral therapy ART baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine CD4+ T cell CD4+ T-cell CD40L Cellular responses characterized Cluster collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 demonstrated dose Efficacy eligibility evaluated expand feature Follow-up group HCs healthy control HIV HIV-infected patient HIV-infected patients Human Human immunodeficiency virus humoral immune response Immunity immunization immunodeficiency virus immunogenicity involved messenger Messenger RNA molecules mononuclear cell mononuclear cells mounted mRNA of BNT162b2 Olink perinatally HIV-infected patients. Peripheral blood Peripheral blood mononuclear cells plasma samples Population populations profile protein level protein levels proteomic proximity extension assay Regulation respiratory response responses RNA RNA coronavirus Safety Sample SARS-CoV-2 SARS-CoV-2 antibody second dose severe acute respiratory syndrome Coronavirus study groups T cell T cells vaccination Vaccine Vulnerable populations were assessed [DOI] 10.1093/cid/ciac408 PMC 바로가기 [Article Type] Article
Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In VitroME/CFS가 있거나 없는 포스트 코로나19 증후군 환자의 혈청은 체외 내피 세포 기능에 차등적으로 영향을 미칩니다Article Published on 2022-08-022022-09-11 Journal: Cells [Category] 바이오마커, [키워드] Activation analysed Angiogenesis autoantibodies autoantibody binding Cell chronic fatigue syndrome compensatory mechanism COVID-19 Cytokines demonstrated develop Diagnostic Criteria dysregulated Effect Encephalomyelitis endothelial endothelial cells Endothelial dysfunction fatigue fatigue syndrome flow cytometry function functional groups healthy control healthy controls hypothesise in vitro investigated involved marker mechanism molecules Myalgic encephalomyelitis/chronic fatigue syndrome nitric oxide Patient patient cohort patient group patient groups patients post-COVID syndrome profile promoted proportion reduced screened secretion sera serum serum cytokines significantly significantly increased small molecule Small molecules syndrome vascular remodelling was measured while [DOI] 10.3390/cells11152376 PMC 바로가기 [Article Type] Article
In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2In-silico 스크리닝 및 in-vitro assay는 SARS-CoV-2에 대한 Indomethacin의 항바이러스 효과를 보여줍니다Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed anti-inflammatory drug Antiviral effect applied can be used caused cellular Comparative Compound compounds Computational drug coronavirus coronavirus disease COVID-19 CTD death Differential gene expression drug drug candidate drug candidates Drug repurposing epithelial cell epithelial cells Gene Expression Host host response human cell human cells human lung human lung epithelial cells humans in-silico In-vitro in-vitro assay indomethacin Infection investigated moderate molecules mRNA expression profile nonsteroidal anti-inflammatory drug Perspective Protein responsible SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread tested the SARS-CoV-2 therapeutic Toxicogenomics treat Treatment Vaccine Vero CCL-81 cell Vero CCL-81 cells viral infection Virtual screening Vitamin was performed [DOI] 10.1016/j.compbiomed.2022.105788 PMC 바로가기 [Article Type] Article
RNA solutions to treat inborn errors of metabolism신진대사의 선천적 오류를 치료하기 위한 RNA 솔루션Review Published on 2022-08-012022-09-11 Journal: Molecular genetics and metabolism [Category] 유전자 메커니즘, [키워드] activating antisense Antisense oligonucleotides approved Biology Chemistry Clinical efficacy clinical trial clinical trials Clinical use COVID-19 drug drugs effective expression gene silencing help IEM include lncRNA mechanism mechanism of action messenger RNAs metabolism MicroRNAs molecules mRNA mutations New offer overcome Patient pharmacokinetic rare disease rare diseases Research RNA RNA interference RNA vaccine RNA vaccines RNAs siRNA splicing Stage suppress target tissues Therapeutic approach therapy tissues treat [DOI] 10.1016/j.ymgme.2022.07.006 PMC 바로가기 [Article Type] Review
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into CellsSARS-CoV-2 세포로의 진입을 완전히 차단하려면 Vacuolar-ATPase 및 TMPRSS2의 이중 억제가 필요합니다Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ATPase bafilomycin block viral entry camostat cathepsin inhibitor Cathepsins Cell cellular Compound coronavirus E64d Efficacy endosomal pH endosomal protease endosome expressing highlight host cell host protease host proteases Hydroxychloroquine identify implicated Infection inhibit inhibiting inhibition inhibitor inhibitors Intervention life cycle Macrolide maturation mechanisms membrane fusion molecules Neutralizing nonspecific Pathways pharmacological agent Prevent protease Protein proteolytic activation provide pseudotyped rationale S protein SARS SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine serine 2 serine proteases severe acute respiratory syndrome Coronavirus synergy the S protein these compound these compounds TMPRSS2 TMPRSS2 inhibitor TMPRSS2-expressing cells toxicities Toxicity transmembrane V-ATPase viral entry viral spike virus [DOI] 10.1128/aac.00439-22 PMC 바로가기 [Article Type] Article