Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages고도로 제한된 SARS-CoV-2 수용체 발현 및 1차 인간 단핵구 및 단핵구 유래 대식세포에 의한 감염에 대한 내성Article Published on 2022-09-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cause caused cellular cellular receptor condition contribute coronavirus COVID-19 Defense direct infection enzyme Express expression facilitated global pandemic immune activation in vitro Infection involved Macrophage macrophages MDM mechanism monocyte monocyte-derived macrophage Monocyte-derived macrophages Monocytes myeloid cell myeloid cells occur Pathogenesis primary human monocyte priming pseudotyped virions receptor remained resistance to infection SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV2 SARS-CoV2 infection Severe acute respiratory syndrome severity spike subtype the disease TMPRSS2 unlikely unpolarized viral spike [DOI] 10.1002/JLB.4COVA1121-579RR PMC 바로가기 [Article Type] Article
From COVID to fibrosis: lessons from single-cell analyses of the human lungCOVID에서 섬유증까지: 인간 폐의 단일 세포 분석에서 얻은 교훈Review Published on 2022-06-132022-09-11 Journal: Human Genomics [Category] 유전자 메커니즘, [키워드] alveolar cell Cell cell population cellular phenotype cellular phenotypes changes in complications COVID COVID-19 COVID-19 pneumonia disease epithelial Features fibrosis Fibrotic interstitial lung disease Gene Expression gene expression pattern gene expression patterns highlight highlighting human lung idiopathic Idiopathic pulmonary fibrosis implication Injury interstitial Interstitial lung disease Interstitial lung diseases IPF IPF cell atlas life-threatening lung Lung disease Lung diseases Macrophage mechanism monocyte-derived macrophage multiple tissue multiple tissues organs parenchymal pathologic condition Pneumonia populations pulmonary fibrosis single-cell analysis Single-cell RNA-sequencing viral disease [DOI] 10.1186/s40246-022-00393-0 PMC 바로가기 [Article Type] Review
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation Research Published on 2022-05-272022-10-05 Journal: Nature Immunology [Category] 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress ARDS ARDS patient Bone marrow circulating monocytes Host Hypoxemia hypoxemic hypoxia hypoxic immune immune response immune responses Inflammation Injury Intervention lung Lung injury mice monocyte-derived macrophage monocytopenia mouse model offer persistence phenotype promote reduced rescued resulting shown Signaling syndrome systemic inflammation therapeutic strategy tissue type I interferon Ventilation [DOI] 10.1038/s41590-022-01216-z [Article Type] Research
Macrophages and Monocytes: “Trojan Horses” in COVID-19Article Published on 2021-10-282022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Cell co-cultured COVID-19 COVID-19 disease D614G different time point dissemination Evolution in vitro in vitro study infect infected cell Infection investigated Italian Lineage lineage B.1.1 MDM monocyte monocyte-derived macrophage non-infected cell SARS-CoV-2 SARS-CoV-2 replication these cell transferred Trojan horse turn variants of SARS-CoV-2 vector VERO E6 cells viral replication Viral transmission virus [DOI] 10.3390/v13112178 PMC 바로가기 [Article Type] Article
Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by MacrophagesResearch Article Published on 2021-09-282022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome ADE antibodies antibody Antibody-dependent enhancement Cell contribute coronavirus coronavirus disease COVID-19 COVID-19 vaccines cytokine production cytokine/chemokine expression detrimental effect elicit enhancement evaluated expressing FcγRIIA FcγRIIIA FcγRs IgG infected with SARS-CoV-2 Infection macrophages Mediated monocyte-derived macrophage pandemic plasma Production proinflammatory raised receptor Reinfection SARS-CoV-2 SARS-COV-2 infection upregulated variants virus [DOI] 10.1128/mBio.01987-21 PMC 바로가기 [Article Type] Research Article
A molecular single-cell lung atlas of lethal COVID-19치명적인 COVID-19의 분자 단세포 폐 지도Article Published on 2021-07-012022-09-12 Journal: Nature [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] activated adopted alteration alveolar Alveolar macrophages Analysis Autopsy Bacterial cause Cell cells cellular complications of COVID-19 contributing to COVID-19 CTHRC1 death Deleterious described died disrupt drug target epithelial feature fibroblast host response individual individuals individuals with COVID-19 Infection Inference infiltration Interaction interactions interleukin-1β interleukin-6 lung lung tissue molecular monocyte-derived macrophage nuclei Patient performed Pneumonia Protein provide pulmonary fibrosis resource respiratory resulting RNA sequencing SARS-COV-2 infection Seven severe SARS-CoV-2 single-cell Survivors T cell responses therapeutic transcriptional undergo unique [DOI] 10.1038/s41586-021-03569-1 PMC 바로가기 [Article Type] Article
CXCL17 Is a Specific Diagnostic Biomarker for Severe Pandemic Influenza A(H1N1) That Predicts Poor Clinical OutcomeImmunology Published on 2021-02-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, 신종인플루엔자, [키워드] A549 cell Admission Algorithm alveolar analyzed Anti-viral assays Autopsy Cell culture chemokine chemokines chemotactic clinical Cohort cohort of patient coronavirus disease COVID-19 COVID-19 patients CXCL17 died ELISA enrolled enzyme-linked immunosorbent evaluated exhibit expressed expression expression pattern functions Future Hospitalization humans immunohistochemistry incidence Influenza influenza A(H1N1) Ligand lung lung tissue machine-learning Mexico City monocyte-derived macrophage Mortality motif myeloid cells other respiratory infection pandemic Patient patients Peripheral blood Peripheral blood sample Poor poor prognosis post-mortem lung predict processed Prognostic value PTB pulmonary tuberculosis Regression analyses renal required respiratory pathogen respiratory tract SARS-CoV-2 Seasonal influenza serum Serum level Seven Specific specimen the disease Tuberculosis utility virus infection was tested [DOI] 10.3389/fimmu.2021.633297 PMC 바로가기 [Article Type] Immunology
Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic InterventionPharmacology Published on 2020-07-292022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 Alpha alveolar cell antagonists Apoptosis AT1 biological marker blockade blockers capillary leakage CDK9 Cell cellular and molecular chemotactic clinical feature clinical marker contribute COVID-19 COVID-19 immune response CRP cytokine release Cytokine storm Cytokines cytoplasmic Defense Degradation Dexamethasone differentiation Diffuse alveolar damage downstream signaling pathway doxycycline element elevated elevated lactate dehydrogenase entry of SARS-CoV-2 epithelial estrogen receptor expression IL-17 IL-6 immune immune response Immunity include infiltration Inflammatory Inflammatory cytokine inflammatory cytokine production inflammatory signaling inhibitor initial Injury interferon response Intervention Ivermectin Jak kinase inhibitors LDH lung tissue MAPK mechanism melatonin membrane fusion membrane-bound molecular monocyte monocyte-derived macrophage NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil-to-lymphocyte ratio NF-κB NLR p65 pathogenic pathophysiology pathway Platelet Pneumocytes Point Potential pro-inflammatory promote Prophylaxis provoke receptor reduce Remdesivir Research respiratory epithelia respiratory epithelial cells SARS-CoV-2 coronavirus selective Signal transduction skewed subtype T-cell therapeutic interventions therapeutic response Therapeutics thrombosis TNF-α type I interferons type III Vascular Viral load virus [DOI] 10.3389/fphar.2020.01169 PMC 바로가기 [Article Type] Pharmacology
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 Research Published on 2020-05-122022-10-05 Journal: Nature Medicine [Category] SARS, 치료기술, [키워드] bronchoalveolar Bronchoalveolar lavage fluid CD8+ T cells characterized COVID-19 healthy Immune cell immune characteristics immune microenvironment monocyte-derived macrophage Pathogenesis Patient patients with COVID-19 potential mechanism respiratory severity severity of COVID-19 Single-cell RNA sequencing [DOI] 10.1038/s41591-020-0901-9 [Article Type] Research
Overexpression of the nucleocapsid protein of Middle East respiratory syndrome coronavirus up-regulates CXCL10Research Articles Published on 2018-09-212022-10-28 Journal: Bioscience Reports [Category] Coronavirus, [키워드] A549 cells addition airway epithelial cell antiviral genes antiviral response cause cells cellular processe CXCL10 dendritic cells determine Factor fibroblast cells Genes high mortality rate Host Human IL6 IL8 independent infected cell Infection interactions knowledge lung MERS-CoV Middle East Middle East respiratory syndrome Coronavirus monoclonal antibody monocyte-derived macrophage motif murine N-terminal domain nucleocapsid nucleocapsid protein overexpressed overexpression Patient PCR Protein regulate regulated reported residue Respiratory disease respiratory syndrome coronavirus secretion selected Severity of disease TNF transcriptional transcriptionally transiently transfected translational up-regulate up-regulated was used [DOI] 10.1042/BSR20181059 PMC 바로가기 [Article Type] Research Articles