Automated, Point-of-Care mobile flow cytometry: Bringing the laboratory to the sampleResearch Article Published on 2024-04-032024-09-05 Journal: Heliyon [Category] update2024, [키워드] eosinophil First line care innate immune activation Mobile flow cytometry monocyte monocyte subsets near patient neutrophil point-of-care systemic inflammation [DOI] 10.1016/j.heliyon.2024.e28883 PMC 바로가기 [Article Type] Research Article
Monocytes subsets altered distribution and dysregulated plasma hsa-miR-21-5p and hsa-miR-155-5p in HCV-linked liver cirrhosis progression to hepatocellular carcinomaarticle Published on 2023-08-282024-09-05 Journal: Journal of Cancer Research and Clinical Oncology [Category] update2024, [키워드] HCC hsa-miR-155-5p hsa-miR-21-5p in silico analysis Liver cirrhosis monocyte subsets [DOI] 10.1007/s00432-023-05313-w PMC 바로가기 [Article Type] article
Non‐classical monocytes frequency and serum vitamin D 3 levels are linked to diabetic foot ulcer associated with peripheral artery diseaseClinical Science and Care Published on 2023-07-022024-09-05 Journal: Journal of Diabetes Investigation [Category] update2024, [키워드] diabetic foot ulcer monocyte subsets Vitamin D3 [DOI] 10.1111/jdi.14048 PMC 바로가기 [Article Type] Clinical Science and Care
Multifaceted Defects in Monocytes in Different Phases of Chronic Hepatitis B Virus Infection: Lack of Restoration after Antiviral TherapyArticle Published on 2022-12-212023-06-13 Journal: Microbiology Spectrum [Category] B형 간염, Fulltext, [키워드] Hepatitis B virus surface antigen IL-4 M2 macrophages monocyte subsets tenofovir Treg β-catenin [DOI] 10.1128/spectrum.01939-22 PMC 바로가기
Immune Cells Profiles In The Peripheral Blood Of Patients With Moderate To Severe COVID-19 And Healthy Subjects With and Without Vaccination With The Pfizer-BioNTech mRNA VaccinePfizer-BioNTech mRNA 백신 접종 여부에 관계없이 중등도에서 중증 COVID-19 환자 및 건강한 피험자의 말초혈 면역 세포 프로필Article Published on 2022-07-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive analyzed B cell B cells Blood causative agent caused CD14 CD16 CD19 CD19+ CD3+ CD4+ CD4+ T cells CD4+ T lymphocyte CD56 CD56+ CD8+ T cell CD8+ T cells clinical manifestations coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detectable determine dysregulated flow cytometry Frequency group healthy control healthy subject healthy subjects HLA-DR host response immune Immune cell immune cells immune response Inflammatory Kuwait lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes moderate moderate to severe monocyte monocyte subsets Monocytes mRNA mRNA vaccine NK cell NK cells no symptom no symptoms percentage percentages peripheral Peripheral blood Perturbation perturbations Pfizer Pfizer-BioNTech profile profiles PROTECT required respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease significantly higher significantly lower subjects subset T cells T lymphocytes the patient three group three groups vaccination was performed with COVID-19 [DOI] 10.3389/fimmu.2022.851765 PMC 바로가기 [Article Type] Article
In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed Anosmia anti-CD3 Antibody titer Antibody titers basal baseline characteristics biochemical blood sample Blood samples CD14 CD16 CD4+ CD8+ T cell CD8+ T cells Cellular immune response cellular immunity classical classical monocytes clinical recovery conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression disease display distress drug Evidence exposure expression Fever Follow-up headache healthy volunteer Human Humoral immunity hypoxia IFN-alpha IFN-gamma IL-2 immune function immune response Immunoglobulin Immunoglobulin G Impaired in vitro interferon interleukin interleukin-2 Invasive mechanical ventilation lipopolysaccharide Mild mild cases monocyte monocyte subsets Monocytes Neutralizing no difference no differences non-classical monocyte Non-classical monocytes not differ participant Patient PD-1 Pneumonia polyclonal predisposition programmed cell death programmed cell death protein prospective cohort study Protein receiving Registered required respiratory respiratory distress response S1 protein SARS-CoV-2 SARS-COV-2 infection serum titer Severe case severe cases severe COVID-19 severity significantly subset Symptom T cell T cells virus worsening [DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article
Dynamic alterations in monocyte numbers, subset frequencies and activation markers in acute and convalescent COVID-19 individuals급성 및 회복기 COVID-19 개인의 단핵구 수, 하위 집합 빈도 및 활성화 마커의 동적 변경Article Published on 2021-10-122022-09-10 Journal: Scientific Reports [Category] Coronavirus, MERS, 바이오마커, 치료기술, 치료제, [키워드] Activation alteration classical monocyte classical monocytes convalescent COVID-19 COVID-19 patient COVID-19 patients CRP Cytokines Day decrease dynamic elevated ELISA Evidence evidence of examined Factor Frequency group Host immunology increase individual individuals intermediate and non-classical monocytes marker Mild disease monocyte Monocyte activation monocyte subsets Monocytes Monocytes and macrophages non-classical monocyte Non-classical monocytes Pathogenesis pathogenesis of COVID-19 performed plasma Plasma levels plateau provide RT-PCR SARS-CoV2 infection Seven severe disease subset thought with mild disease [DOI] 10.1038/s41598-021-99705-y PMC 바로가기 [Article Type] Article
Impaired function and delayed regeneration of dendritic cells in COVID-19코로나19에서 손상된 수지상 세포의 기능 장애 및 재생 지연Clinical Trial Published on 2021-10-062022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 바이오마커, 임상, [키워드] accompanied activated acute illness acute phase adaptive Adaptive immune response adaptive immune responses alteration analyzed antibody antibody-secreting cells antiviral immunity Blood CD14 CD14+ cell CD14+ cells CD163 CD4 CD86 Cell cells circulating classical monocyte classical monocytes Clinical management consequence contribute correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity DCs dendritic cell dendritic cells Depletion disease disease severity downregulation dysregulated dysregulated innate immune response expansion follicular Frequency functional healthy controls helper cells HLADR hospitalized COVID-19 patient Host immune response identify immune responses immunopathology Impaired impairment Increased Inflammatory response Inflammatory responses inhibitory innate immune response long-lasting manifestation Mild modulation monocyte monocyte subsets Monocytes naïve Patient PD-L1 persistent recognize reduced reduction regeneration SARS-COV-2 infection Secondary infection secondary infections severe disease stimulate subpopulation subset susceptibility systemic inflammation T cell T cells T follicular helper cells the disease therapy these cell These cells Trigger upregulation Viral viral infection viral infections [DOI] 10.1371/journal.ppat.1009742 PMC 바로가기 [Article Type] Clinical Trial
Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumoniaCOVID-19 폐렴 환자에서 변경된 생체 에너지 및 단핵구의 미토콘드리아 기능 장애Report Published on 2020-11-052022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] aerobic aerobic glycolysis Affect Altered analyzed basal bioenergetics CCL2 cells chemokines classical monocytes COVID‐19 COVID‐19 CXCL10 Cytokines diminished expression Extracellular Glycolysis GM‐CSF high plasma levels IFN‐γ immature immunology Immunopathogenesis in vitro increased expression Inflammation Inflammatory cytokine Inflammatory cytokines inhibitors inhibitory inhibitory checkpoints Innate immunity investigation membrane membrane potential Microbiology, Virology & Host Pathogen Interaction Mitochondria mitochondrial mitochondrial dysfunction monocyte monocyte subsets Monocytes osteopontin oxidative burst OXPHOS Patient PD‐1 Peripheral blood peripheral blood monocytes plasma Pneumonia producing redistribution reduced respiratory capacity SARS‐CoV‐2 SARS‐CoV‐2 infection significantly subset these cell These cells TNF ultrastructure [DOI] 10.15252/emmm.202013001 PMC 바로가기 [Article Type] Report
Macrophage Polarization in Leprosy–HIV Co-infected Patients한센병-HIV 동시 감염 환자에서 대식세포 극성화Original Research Published on 2020-07-292024-08-01 Journal: Frontiers in immunology [Category] 한센병, [키워드] Co-infection HIV-1 leprosy macrophage phenotype monocyte subsets [DOI] 10.3389/fimmu.2020.01493 PMC 바로가기 [Article Type] Original Research