Opioid-blunted cortisol response to stress is associated with increased negative mood and wanting of social reward Research Published on 2022-02-092022-10-05 Journal: Neuropsychopharmacology [Category] 바이오마커, [키워드] Acute stress administration Affect animal double-blind elicited Evidence female healthy HPA Human morphine participant Placebo prevented Psychosocial stress Randomized reaction receptor Regulation Research salivary seeking social contact Stress Volunteer were assessed [DOI] 10.1038/s41386-022-01283-8 [Article Type] Research
Opioids in COVID-19: Two Sides of a CoinPharmacology Published on 2022-01-062022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] “COVID-19 accounted adverse effect adverse effects Affect affected alfentanil applicability Brazil can be used Care coin confirmed case confirmed COVID-19 case country COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients database decrease disorder distribution dose drug ENhance evaluate evaluated exacerbate facilitate fentanyl greater Health High dose higher risk Hospitalization hydromorphone hypnotics individual intubation management measure Methadone morphine Mortality Occurrence opioid opioid use disorder and dependence Pain pandemic performed positive Region remifentanil reported respiratory depression severe COVID-19 patient side social isolation South Spread sufentanil the SARS-CoV-2 Tolerance Treatment ventilatory support were used [DOI] 10.3389/fphar.2021.758637 PMC 바로가기 [Article Type] Pharmacology
MeCP2 Epigenetic Silencing of Oprm1 Gene in Primary Sensory Neurons Under Neuropathic Pain ConditionsOriginal Research Published on 2021-11-052024-09-02 Journal: Frontiers in Neuroscience [Category] 대상포진, [키워드] DNA methylation histone acetylation MOR morphine neuropathic pain [DOI] 10.3389/fnins.2021.743207 PMC 바로가기 [Article Type] Original Research
Wahrnehmungen zum Umgang mit Opioiden bei COVID-19 Eine Umfrage unter Mitgliedern der Deutschen Gesellschaft für PalliativmedizinOriginalien Published on 2021-10-182022-10-29 Journal: Schmerz (Berlin, Germany) [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] COVID-19 material Morphin morphine opioid Opioide Palliative care Palliativmedizin survey Symptom control Symptomkontrolle [DOI] 10.1007/s00482-021-00596-9 PMC 바로가기 [Article Type] Originalien
Epidural morphine in COVID ARDS patients with high respiratory drive: a structured summary of a study protocol for a randomised controlled trial높은 호흡 드라이브가 있는 COVID ARDS 환자의 경막외 모르핀: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-09-162022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 28-day mortality Abnormalities acceptance administer Administered Admission Adult patient Adult patients allocation ARDS patient aseptic technique assistant average blind Blinding both group both groups catheterization Coagulation comparator Patients control group COVID COVID 19 patient COVID 19 patients COVID-19 criteria CTRI death discharge dissemination dose doses double blind Dyspnoea element Endotracheal intubation Epidural epidural catheter Epidural morphine epidural space Escalation exclusion criteria fixed fraction greater Group allocation HCO hypoventilation Hypoxemia ICU ICU patient inclusion criteria India injection Intervention intervention group intubation involved list Local maximum mechanical ventilation Medical Science Medical Sciences Metabolic acidosis minimum morphine morphine sulphate Mortality NIV non-invasive ventilation number Nurse objective outcome Pain parameters participant Patient Patient self-induced lung injury patients with COVID19 physician Placebo protocol random randomisation randomised randomised controlled trial recruited reduce Registered registry Research respiratory respiratory acidosis Respiratory drive respiratory parameters resulting Sample size sealed second dose secondary Secondary outcomes Sedation Sepsis severe hypoxemia sitting position skin Source Study protocol sulphate supplementary material team the patient Trial ventilator parameters website with COVID-19 [DOI] 10.1186/s13063-021-05570-5 PMC 바로가기 [Article Type] Letter
Palliative Sedation in COVID-19 End-of-Life Care. Retrospective Cohort StudyArticle Published on 2021-08-262022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] acquisition administration Admission ALC Alicante breathlessness Care Community COVID-19 Cross-sectional studies death Deceased description died Dyspnea evaluated initiated Inpatient interquartile range IQR less Material and Method median age median time Mental morphine nosocomial Pain palliative Palliative care palliative medicine Patient patients evaluated patients with COVID-19 recognize regimen registry retrospective cohort study Sedation Symptom Symptom assessment university was used with COVID-19 women [DOI] 10.3390/medicina57090873 PMC 바로가기 [Article Type] Article
An 8-Week Self-Administered At-Home Behavioral Skills-Based Virtual Reality Program for Chronic Low Back Pain: Double-Blind, Randomized, Placebo-Controlled Trial Conducted During COVID-19만성 요통을 위한 8주 자가 관리 재택 행동 기술 기반 가상 현실 프로그램: COVID-19 동안 수행된 이중 맹검, 무작위, 위약 대조 시험Randomized Controlled Trial Published on 2021-02-222022-08-13 Journal: Journal of Medical Internet Research [Category] MERS, 임상, [키워드] 1:1 average back back pain baseline behavioral health chronic chronic low back pain chronic pain clinically collected comparison COVID-19 COVID-19 pandemic determine disturbance double-blind effect size effective enrolled expand female function highest Identifier individual intensity Intention intention-to-treat interaction effect low back pain mechanism medication moderate mood morphine National Nonpharmacologic Treatment objective opioid opioids outcome Pain pain intensity pain relief pain treatment, randomized controlled trial pain-related interference physical prescription prevalent Primary outcome Primary outcomes Program Randomized randomized placebo-controlled trial ranged REALITY reduced reduced pain reduction Registration report representing Research Result Satisfaction secondary Secondary outcomes Self-efficacy Sleep Sleep disturbance statistical significance Stress Symptom treat Treatment treatment effect treatment effects user virtual reality was reduced [DOI] 10.2196/26292 PMC 바로가기 [Article Type] Randomized Controlled Trial
Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkAReview Published on 2018-10-062023-08-29 Journal: Proteomes [Category] E형 간염, [키워드] Analgesia conformational antibody GPCR signaling morphine Opioid receptors [DOI] 10.3390/proteomes6040039 PMC 바로가기 [Article Type] Review