Population-weighted exposure to green spaces ties to lower COVID-19 mortality rates: A nationwide dose-response study in the USAResearch article Published on 2022-12-012022-10-05 Journal: The Science of the total environment [Category] 유전자 메커니즘, 진단, [키워드] adjusted adopted association buffer caused chronic disease confidence interval Contact with nature COVID-19 mortality COVID-19 pandemic Critical decrease distribution ecological Effect effect size environmental factors forest greater Health increase in investigated knowledge Landscape planning and design linear mechanism mitigate mixed-effects model Mortality mortality rate mortality rates Nearby nature Optimal dose of nature promote PROTECT Regulation Research risk of COVID-19 SARS-CoV-2 Sociodemographic USA with COVID-19 [DOI] 10.1016/j.scitotenv.2022.158333 [Article Type] Research article
Safety and immunogenicity of MVC-COV1901 vaccine in older adults: Phase 2 randomized dose-comparison trialArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] 진단, [키워드] Administered adverse event age binding antibody clinical trial Comorbidities Comorbidity COVID-19 infection demonstrated dose double-blind elicited General population High dose High-dose immune response immunization immunogenicity immunosenescence Mild mortality rates MVC-COV1901 vaccine negative correlation Neutralizing Older older adult Older adults participant Phase 2 protein subunit vaccine Randomized regimen Registered robust Safety SARS-CoV-2 stratified subject Trial Vaccine [DOI] 10.1016/j.ijid.2022.08.021 PMC 바로가기
Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid TreatmentArticle Published on 2022-10-112022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] acquisition Amino acid analysed Analysis arginine caused Cohort Concentration COVID-19 COVID-19 infection COVID-19 infections COVID-19 pathogenesis dataset degranulation Dexamethasone dysregulation effective feature glucocorticoid Glucocorticoid treatment Glucocorticoids Guidance highlight include indicated Interaction mass spectrometry metabolomics modulation mortality rates Multi-omics neutrophil oxygen supplementation pandemic Partial participant pathway Pathway analysis Patient Platelet proteomics Quantitative serum statistically significant Treatment treatment regimen tyrosine was performed [DOI] 10.3390/ijms232012079 PMC 바로가기
The paradox of pulmonary arterial hypertension in Italy in the COVID-19 era: is risk of disease progression around the corner?Article Published on 2022-10-062022-11-15 Journal: The European Respiratory Journal [Category] COVID19(2023년), SARS, 진단, [키워드] activity acute respiratory syndrome Brain Care clinician collected comparable conducted consequence coronavirus coronavirus disease COVID-19 death demographic data determine diagnose diagnosed Disease progression echocardiographic effective Escalation functional Healthcare provider hospitalisation incidence incidence of COVID-19 Infection Italian Italian population Italy less management material measure Mortality mortality rates multicentre outbreak outcome PAH Patient patients patients with COVID-19 peptide potential risk public health pulmonary arterial hypertension reduction in remote monitoring resulting risk SARS-CoV-2 Treatment World Health Organization [DOI] 10.1183/13993003.02276-2021 PMC 바로가기
Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection: prospects for useArticle Published on 2022-10-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] absence antidepressant antidepressants antiviral drug approved article benefit Care Clinical outcome clinical trial coronavirus COVID COVID-19 database death decrease drug effort Hospitalization Infection infections information inhibit inhibitor Intensive intubation methodological flaws Mild-to-moderate mortality rates Novel coronavirus pandemic patients receptor Redirection reduce reported repositioning Repositioning. Research risk SARS-CoV-2 SciELO selective Serotonin shown specific treatment therapeutic intervention Toxicity treat Treatment viral titer was performed [DOI] 10.1007/s00228-022-03372-5 PMC 바로가기
SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concernArticle Published on 2022-09-182022-10-06 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] absence ACE2 acute respiratory syndrome ADK antibody BA.2 BA.5 Beta BNT162b2 breadth Breakthrough infection cell line change circulating clade Clinical effect cohorts contributed convalescent convalescent sera coronavirus COVID-19 COVID-19 hospitalisation Delta development disease severity Donor donors dose foundation Future genetic difference greater humoral Humoral response IgG in vitro isolate Lineage lineages Live virus management monitoring monoclonal antibody mortality rates nafamostat nasopharyngeal sample nasopharyngeal swabs neutralisation neutralisation assay Neutralising Antibodies neutralising antibody New observation of BNT162b2 omicron Omicron BA.1 other variant pathway peak plasma potency recorded reduced reduction reduction in Research response responses SARS-CoV-2 sensitivity significantly Sotrovimab South Spread Support supported tested Testing therapeutic Therapies TMPRSS2 TMPRSS2 inhibitor Transmission utilised vaccination Vaccine variant viral lineage viral variant [DOI] 10.1016/j.ebiom.2022.104270 PMC 바로가기 [Article Type] Article
Spatial clusters, social determinants of health and risk of COVID-19 mortality in Brazilian children and adolescents: A nationwide population-based ecological studyResearch article Published on 2022-09-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 치료기술, [키워드] adolescents Analysis association Beta Brazil children Cluster Clusters country COVID-19 COVID-19 case COVID-19 incidence COVID-19 mortality death deaths distribution ecological estimate finding funding geographical distribution Health health inequities health system K-means clustering Mortality mortality rates municipality North Poisson Probability reduce Region regions risk risk factor risk of COVID-19 social determinant social determinants of health Spatial distribution stratified were recorded [DOI] 10.1016/j.lana.2022.100311 [Article Type] Research article
First wave of SARS-CoV-2 in Santiago Chile: Seroprevalence, asymptomatic infection and infection fatality rateArticle Published on 2022-09-012022-11-15 Journal: Epidemics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] adjusted affected age antibody antibody isotypes Asymptomatic asymptomatic infection asymptomatic patient attack rate calculated change Chile confirmed case contribute country COVID-19 cross-sectional detect Diseases Epidemic estimates fatality Fatality rate First wave Health health system heterogeneous highlight IgG IgM IgM and IgG indicate individual Infection Infection fatality rate infection prevalence information initial knowledge majority mortality rates MOST occurred pandemic produced provide reached Registered remained reported SARS-CoV-2 SARS-COV-2 infection seropositive Seroprevalence Serosurvey Seven Sex significant difference Spread Stress subpopulation susceptible symptomatic Threats were used [DOI] 10.1016/j.epidem.2022.100606 PMC 바로가기
Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients코로나19 환자에서 다양한 비타민과 미네랄의 분자 기전과 치료 효과Review Published on 2022-09-012022-09-11 Journal: Journal of trace elements in medicine and biology [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] activities addition Anti-inflammatory drugs antioxidant antioxidants Antiviral antiviral properties antiviral property boost component copper correlation COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness cytokine release Cytokines disease Effect Factor Health high mortality immune function immune functions immune system Increased Infectious disease Inflammation Inflammatory cytokine Inflammatory cytokines iron lack manganese mechanism metabolic processe metabolic processes Micronutrient micronutrients mineral Minerals modulate mortality rate mortality rates oxidative stress Prevalence rapidly spreading disease reason remedy respiratory distress SARS-CoV-2 Selenium severe COVID-19 Severe respiratory distress Support therapeutic effect Trace element trace elements Treatment Vitamin vitamin A vitamins Zinc [DOI] 10.1016/j.jtemb.2022.127044 PMC 바로가기 [Article Type] Review
Allelic Variations in the Human Genes TMPRSS2 and CCR5, and the Resistance to Viral Infection by SARS-CoV-2인간 유전자 TMPRSS2 및 CCR5의 대립형질 변이와 SARS-CoV-2에 의한 바이러스 감염에 대한 내성Article Published on 2022-08-152022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] addition age allelic variant allelic variants analyzed CCR5 CCR5 gene Clinical course close contact Comorbidities Comorbidity conditions contact with correlation COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 infection demonstrated described determinant Disease progression disease severity Europe explain First wave Gender Genetic polymorphism genetic variability highest Human human genes human populations identify Italy life cycle male mortality rate mortality rates old age performed polymorphism predisposition progression resistance rs12329760 rs333 rs35074065. SARS-CoV-2 SARS-CoV-2 first wave infection SARS-COV-2 infection SARS-CoV-2 viral Sicily subject subjects TMPRSS2 TMPRSS2 gene viral infection virus virus infection with COVID-19 [DOI] 10.3390/ijms23169171 PMC 바로가기 [Article Type] Article