Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19COVID-19에 대한 인간 면역 시스템(HIS) 인간화 마우스 모델(DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD)Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] SARS, 유전자 메커니즘, [키워드] Anti-viral B cell Blood candidate vaccine CD4 CD8 Cell clinical condition Cord blood COVID-19 COVID-19 research cytotoxic activity DRAGA mice Efficacy epithelial Express expressing functional granzyme B Hematopoietic stem cell Human human ACE2 receptor human antibodies Human immune system human lung-resident CD8 T cells humanized humanized mice IgG antibody immune immunopathological in vivo infused intra-alveolar lung lung immunopathology lung immunopathology. Lungs lymphocyte mechanism mice microthrombi mounted perforin promote Proteins replicating virus response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral secreted surrogate switching System T cell T cells Therapeutics unique upper respiratory airway Viral proteins [DOI] 10.1080/21645515.2022.2048622 PMC 바로가기 [Article Type] Article
Robust neutralizing antibody response to SARS-CoV-2 mRNA vaccination in adolescents and young adults with childhood-onset rheumatic diseasesArticle Published on 2022-11-022022-11-15 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, 치료기술, [키워드] adverse event childhood-onset rheumatic disease Chinese Cohort COVID-19 COVID-19 infection cPass™ cut-off defined disease Disease activity dose Efficacy evaluate female first vaccination humoral immunogenicity immunogenicity increased the risk inhibition median medication Most patient mounted mRNA vaccination mRNA vaccine neutralization Neutralizing antibodies Neutralizing antibody response neutralizing response not affect Paediatric age paediatric rheumatology Patient positive predictor proportion remained response rheumatic disease SARS-CoV-2 SARS-CoV-2 vaccine second vaccination Serious Adverse Event serious complication Seven subgroup analysis symptomatic the SARS-CoV-2 the vaccine two-dose regimen vaccination Vaccine vaccine efficacy vaccine safety were assessed [DOI] 10.1093/rheumatology/keac105 PMC 바로가기
Longitudinal serologic and viral testing post-SARS-CoV-2 infection and post-receipt of mRNA COVID-19 vaccine in a nursing home cohort-Georgia, October 2020‒April 2021Article Published on 2022-10-272022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] administration Antibody detection Antibody Response binding binding antibody blood collection Card Cohort conducted COVID-19 COVID-19 vaccination COVID-19 vaccine Culture detectable dose evaluate evaluated Final first dose geometric IgA antibodies IgA antibody IgG IgG titer IgM antibodies immune response Immunocompromised Infection longitudinal median age mounted mRNA nasal nine nursing home observation participant polymerase chain positive Post-infection Quantitative questionnaire reverse transcription robust RT-PCR SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2-specific immune response serology specimen subsequent vaccination viral culture [DOI] 10.1371/journal.pone.0275718 PMC 바로가기
SARS-CoV-2 Spike-Binding Antibody Longevity and Protection from Reinfection with Antigenically Similar SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome advanced age analyzed antibodies antibody antibody durability Antibody titer circulation Cohort collected convalescent coronavirus coronavirus disease COVID-19 decrease detectable determine Effectiveness Enrollment exceptional female Health care worker highlight immune responses Increases Infection initial limit Longevity median modeling mounted new SARS-CoV-2 occurred Pandemics participant Participants protection public health crisis Rapid Reinfection risk SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 variant seronegative seropositive seropositive participant severe COVID-19 Sex spike-binding antibodies. stability Steady state vaccination variants of concern viruses [DOI] 10.1128/mbio.01784-22 PMC 바로가기
Differential vaccine-induced kinetics of humoral and cellular immune responses in SARS-CoV-2 naive and convalescent health care workersArticle Published on 2022-10-032022-11-15 Journal: Pathogens and disease [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] assays B-cell baseline booster booster vaccines cellular Cellular immune response convalescent convalescent individual Coronavirus-2 determine ELISA ELISPOT ELISpot IFN-γ release assay first dose Health care worker health care workers hospital humoral humoral immune responses Humoral immunity IFN-γ IgG level IgG responses immune individual individuals interferon-γ janssen mounted mRNA mRNA vaccine natural immunity Netherlands occurred offer pandemic Pfizer postvaccination receiving recipient responses SARS-CoV-2 serological seronegative seropositive severe disease spike-specific cellular immunity Support T-cell T-cell Response vaccination Vaccine variants of concern vector vaccine Virus neutralization VNT waned [DOI] 10.1093/femspd/ftac035 PMC 바로가기
Differential Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Profiles After Allergic Reactions to Messenger RNA Coronavirus Disease 2019 VaccineArticle Published on 2022-09-282022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome allergic allergic reaction anaphylaxis antibody antigenic target Control controls coronavirus coronavirus 2 coronavirus disease COVID-19 exhibiting full-length functional humoral Humoral immunity hypersensitivity IgG1 Immunoglobulin individual messenger Messenger RNA Moderna mounted mRNA mRNA COVID-19 vaccine occur Patient Pfizer produced profile reaction receptor recipients reduction in respiratory RNA SARS-CoV-2 significantly lower Symptom systems serology vaccination Vaccine [DOI] 10.1093/infdis/jiac107 PMC 바로가기
Loss of Pfizer (BNT162b2) Vaccine-Induced Antibody Responses against the SARS-CoV-2 Omicron Variant in Adolescents and AdultsArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] Adolescent adolescents adolescents and adult adolescents and adults Adults age antibody Antibody binding antibody binding titers approved Beta binding binding antibody BNT162b2 BNT162b2 vaccine booster booster dose booster vaccination breadth changes in children circulating clinical trial Cohort Coverage COVID-19 Delta demonstrated dose drug Effectiveness Efficacy evaluate FDA food Gamma highlight Hospitalization humoral immune response lack less Loss magnitude mounted mRNA vaccine neutralization Neutralizing antibody response omicron Omicron (B.1.1.529) pandemic pediatric Pfizer Pfizer-BioNTech Pfizer-BioNTech (BNT162b2) plasma populations PROTECT reduction reported Research response responses against robust SARS-CoV-2 seasonal beta coronavirus the antibody response the SARS-CoV-2 the vaccine vaccination Vaccine vaccine-induced antibody response Vaccine-induced immunity variant variant of concerns (VOCs) variants viral variant Virus neutralization virus spike protein VoC VOCs while wild-type SARS-CoV-2 [DOI] 10.1128/jvi.00582-22 PMC 바로가기
SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 proteinArticle Published on 2022-09-122022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] activities antiviral response binding catalytic domain Cell cellular metabolism complexes conserved Critical enzyme exhibit experiments expressed form group inhibitor Innate immunity interact Interaction investigated knock-out lysine marker MAVS mounted non-structural protein Protein reduced residues SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral SIRT5 stable complex therapeutic interventions Treatment viral replication [DOI] 10.1371/journal.ppat.1010811 PMC 바로가기
EQUIP emergency: can interventions to reduce racism, discrimination and stigma in EDs improve outcomes?Clinical Trial Published on 2022-09-022022-10-05 Journal: BMC health services research [Category] 임상, [키워드] activities activity age Analysis Canada Care clinical collected Community COVID 19 death Department dimension discrimination Emergency Emergency Departments Epidemic equity group Health Health disparities health equity Health inequity IMPROVE Indigenous intensity Intervention Intervention research longitudinal mounted Multiple regression overdose pandemic Patient post-intervention presenting promote question racism reduce reduction Research resource robust shown sick significant decrease significantly Stigma supported survey tested Throughout the study trauma was tested worsening [DOI] 10.1186/s12913-022-08475-4 PMC 바로가기 [Article Type] Clinical Trial
Reduced Immune Response and Neutralizing Antibody Activity to the SARS-CoV-2 Vaccination in Patients with a History of Solid Organ TransplantArticle Published on 2022-09-012022-11-15 Journal: Laboratory medicine [Category] SARS, 변종, 진단, 치료기술, [키워드] activity Allogeneic antibodies antibody booster Cell Control controls COVID-19 healthcare worker history immune immune response in vitro monoclonal mounted Neutralizing activity neutralizing antibody nucleocapsid organ Patient patients plasma positive produced reduced Remnant response Sample SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 vaccination Solid solid organ solid organ transplant Spike protein the antibody the SARS-CoV-2 Transplant vaccination variant virus was obtained wild type [DOI] 10.1093/labmed/lmac038 PMC 바로가기