Computational evaluation and benchmark study of 342 crystallographic holo-structures of SARS-CoV-2 Mpro enzymeArticle Published on 2024-06-202024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] antivirals conformational analysis coronavirus COVID-19 MPro Protein structure predictions SARS-CoV-2 Structural clustering Virtual drug screening Virtual screening [DOI] 10.1038/s41598-024-65228-5 PMC 바로가기 [Article Type] Article
Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CL pro main protease (Mpro) from proteomic identification of P6—P6′ active site specificityPathogenesis and Immunity Published on 2024-06-142024-09-05 Journal: Journal of virology [Category] update2024, [키워드] COVID-19 MPro oxidised methionine P' side peptide assays PICS proteomics SARS-CoV-2 structure activity relationship [DOI] 10.1128/jvi.00049-24 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Development of a Biosafety Level 1 Cellular Assay for Identifying Small-Molecule Antivirals Targeting the Main Protease of SARS-CoV-2: Evaluation of Cellular Activity of GC376, Boceprevir, Carmofur, Ebselen, and SelenoneineArticle Published on 2024-05-252024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] binding energy calculation boceprevir Carmofur Ebselen GC376 MPro SARS-CoV-2 selenoneine [DOI] 10.3390/ijms25115767 PMC 바로가기 [Article Type] Article
Kinetic comparison of all eleven viral polyprotein cleavage site processing events by SARS-CoV-2 main protease using a linked protein FRET platformResearch Article Published on 2024-05-152024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] 3CL Protease 3CLpro coronavirus enzyme kinetics FRET main protease MPro polyprotein protease substrate SARS-CoV-2 viral protease [DOI] 10.1016/j.jbc.2024.107367 PMC 바로가기 [Article Type] Research Article
Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main proteaseArticle Published on 2024-01-122024-09-05 Journal: bioRxiv [Category] update2024, [키워드] MPro nsp5 SARS-CoV-2 TRMT1 tRNA [DOI] 10.1101/2023.02.10.527147 PMC 바로가기 [Article Type] Article
In silico anti-viral assessment of phytoconstituents in a traditional (Siddha Medicine) polyherbal formulation – Targeting Mpro and pan-coronavirus post-fusion Spike proteinArticle Published on 2023-07-132024-09-05 Journal: Journal of Traditional and Complementary Medicine [Category] update2024, [키워드] COVID-19 Dynamics iddha medicine Kabasura kudineer molecular docking MPro Post fusion spike protein SARS-CoV-2 [DOI] 10.1016/j.jtcme.2023.07.004 PMC 바로가기 [Article Type] Article
Structure-based virtual identification of natural inhibitors of SARS-CoV-2 and its Delta and Omicron variant proteinsarticle Published on 2023-06-012024-09-05 Journal: Future Virology [Category] update2024, [키워드] antivirals Delta Helicase MPro natural products omicron SARS-CoV-2 spike [DOI] 10.2217/fvl-2022-0184 PMC 바로가기 [Article Type] article
In silico assessment of diterpenes as potential inhibitors of SARS-COV-2 main proteasearticle Published on 2023-05-222024-09-05 Journal: Future Virology [Category] update2024, [키워드] Diterpenes inhibitors molecular docking MPro SARS-CoV-2 [DOI] 10.2217/fvl-2022-0163 PMC 바로가기 [Article Type] article
SARS-CoV-2 main protease inhibitors: What is moving in the field of peptides and peptidomimetics?Article Published on 2023-05-012023-07-11 Journal: Journal of peptide science : an official publication of the European [Category] COVID19(2023년), [키워드] covalent COVID-19 inhibitors main protease MPro peptides peptidomimetics. SARS-CoV-2 [DOI] 10.1002/psc.3467 PMC 바로가기
Resistance to nirmatrelvir due to mutations in the Mpro in the subvariants of SARS-CoV-2 Omicron: Another concern?Editorial Published on 2023-04-062024-09-05 Journal: Molecular Therapy. Nucleic Acids [Category] update2024, [키워드] MPro Nirmatrelvir Omicron subvariant SARS-CoV-2 significant mutation [DOI] 10.1016/j.omtn.2023.03.013 PMC 바로가기 [Article Type] Editorial