IL-10/IL-6 ratio from nasal & oral swab samples, acts as an inflammatory indicator for COVID-19 patients infected with the delta variantResearch Article Published on 2023-06-032024-09-05 Journal: Heliyon [Category] update2024, [키워드] COVID-19 delta variant IL-10 IL-6 MUC5AC nasal swab oral swab SARS-CoV-2 vaccination [DOI] 10.1016/j.heliyon.2023.e16985 PMC 바로가기 [Article Type] Research Article
Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung DiseaseArticle Published on 2022-12-012023-07-09 Journal: American Journal of Respiratory and Critical Care [Category] COVID19(2023년), [키워드] airway mucin. COVID-19 MUC5AC MUC5B SARS-CoV-2 [DOI] 10.1164/rccm.202111-2606OC PMC 바로가기
Histological characteristics of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in asthmatic murine model during A(H1N1)pdm09 infectionArticle Published on 2022-10-012023-06-24 Journal: Pathology international [Category] 신종인플루엔자, [키워드] bronchial epithelial cells Influenza MUC1 MUC5AC occludin ovalbumin pandemic plastic bronchitis tight junction [DOI] 10.1111/pin.13268
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthmaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] addition allergic Allergic asthma Analysis approach association Asthma asthmatic bioinformatics Biomarker can be used candidate drug candidate drugs Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression COVID-19 symptom Critical dataset datasets DEGs determine differentially expressed gene disease disease biomarker drug Effect elevated Evidence expression level Gene ontology Genes health systems hub gene identify IL-13 IL-5 Increasing Interaction interactions lung mechanism molecular molecular mechanism MUC5AC murine murine model pandemic pathway Pathway analysis Patient patients with COVID-19 phenotype potential molecular risk factor severity shared pathways statistical Systems biology systems-biology. Transcription [DOI] 10.3389/fimmu.2022.988479 PMC 바로가기
Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary DiseaseArticle Published on 2022-08-312023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] Air-liquid interface airway epithelium cell sloughing ciliated cells COPD COVID-19 goblet cell hyperplasia goblet cells MUC5AC MUC5B SARS-CoV-2 syncytium [DOI] 10.1128/spectrum.00459-22 PMC 바로가기
Efficacy of salmeterol and magnesium isoglycyrrhizinate combination treatment in rats with chronic obstructive pulmonary disease Research Published on 2022-07-192022-10-05 Journal: Scientific Reports [Category] 바이오마커, 치료제, [키워드] Adverse reaction airway Anti-inflammatory Bronchoalveolar lavage fluid characterized chronic inflammation chronic obstructive Clinical treatment Combination combination treatment contributing to COPD glucocorticoid Hormones IL-1β IL-6 infiltration inflammatory cell involved JAK/STAT signaling pathway Lung function Lung inflammation Lymphocytes Magnesium isoglycyrrhizinate mechanism MUC5AC neutrophil Patient propionate pulmonary disease receptor reduced salmeterol xinafoate secretion serum steroidal anti-inflammatory drugs suggested TNF-α Treatment White blood cells [DOI] 10.1038/s41598-022-16775-2 [Article Type] Research
Influence of SARS-CoV-2 on airway mucus production: A review and proposed modelReview Published on 2022-07-012023-07-07 Journal: Veterinary pathology [Category] COVID19(2023년), [키워드] airway COVID-19 Histamine MUC5AC MUC5B Mucus obstruction. SARS-CoV-2 [DOI] 10.1177/03009858211058837 [Article Type] Review
The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness Research Published on 2022-06-292022-10-05 Journal: Nature Communications [Category] 신약개발, 유전자 메커니즘, [키워드] Analysis association cause clinically correlation death Diagnosis Evidence Genetic genetic architecture genetics histocompatibility complex region identify implicated mapped Meta-analysis MUC5AC Necrosis overlap pathway phenotype Pneumonia Precision Psychiatric receptor risk risk score smoking Support susceptibility target targets TNFRSF1A Treatment utilised variant widespread [DOI] 10.1038/s41467-022-31473-3 [Article Type] Research
SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13기도 세포의 SARS-CoV-2 감염은 IL-13에 의해 영향을 받는 두 가지 확산 메커니즘인 강력한 바이러스 및 세포 방출을 유발합니다Article Published on 2022-04-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected airway airways Allergic asthma Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Asthma asthmatic cause caused Cell Cell culture cell cultures cell tropism cells ciliated cell ciliated cells coronavirus COVID-19 COVID-19 severity down-regulated gene down-regulated genes electron microscopy enzyme epithelial epithelial cells examined expression gene expression analyses Gene Expression Omnibus Genes glycoprotein HAE high risk host–virus interaction human airway human airway epithelial human airway epithelial cells IL-13 IL-13 cytokine immunohistochemistry In situ hybridization infected cells Infection interferon interleukin interleukin-13 Intracellular involved keratan sulfate Lung disease mechanism Messenger RNA Microscopy MUC5AC mucin Mucus number of infected primary human airway reduced removal Replication RNA RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shedding shielding significantly Spread sulfate susceptibility Transmission Transport TRAP treated up-regulated viral egress viral entry Viral load Viral reservoir viral spread viral titers virions viruses were infected [DOI] 10.1073/pnas.2119680119 PMC 바로가기 [Article Type] Article
Poking COVID-19: Insights on Genomic Constraints among Immune-Related Genes between Qatari and Italian Populations코로나19 파헤치기: 카타르인과 이탈리아인 사이의 면역 관련 유전자 사이의 게놈 제약에 대한 통찰력Article Published on 2021-11-222022-09-10 Journal: Genes [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ABCA7 applied candidate gene Care cohorts country COVID-19 COVID-19 cases COVID-19 severity curated Delta demonstrated disease Epicentre Europe FLNA genetic constraints genetic difference genetic differences genomic information genomic variations higher risk highest host-pathogen interaction identify individuals Innate immunity insight involved Italian Italian population Italy laboratory-confirmed lockdown Metrics mortality rate mortality rates MUC5AC National Population Population genetics populations Result selective sequence spread of COVID-19 SSC subset susceptibility vaccination variant whole-genome sequencing [DOI] 10.3390/genes12111842 PMC 바로가기 [Article Type] Article