Are MUC5B and TERT mutations genetic risk factors for pulmonary fibrosis in individuals with severe COVID-19?Research Article Published on 2023-03-102024-09-05 Journal: Tüberküloz ve toraks [Category] update2024, [키워드] MUC5B polymorphism SARS-CoV-2 TERT [DOI] 10.5578/tt.20239905 PMC 바로가기 [Article Type] Research Article
Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung DiseaseArticle Published on 2022-12-012023-07-09 Journal: American Journal of Respiratory and Critical Care [Category] COVID19(2023년), [키워드] airway mucin. COVID-19 MUC5AC MUC5B SARS-CoV-2 [DOI] 10.1164/rccm.202111-2606OC PMC 바로가기
Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary DiseaseArticle Published on 2022-08-312023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] Air-liquid interface airway epithelium cell sloughing ciliated cells COPD COVID-19 goblet cell hyperplasia goblet cells MUC5AC MUC5B SARS-CoV-2 syncytium [DOI] 10.1128/spectrum.00459-22 PMC 바로가기
Influence of SARS-CoV-2 on airway mucus production: A review and proposed modelReview Published on 2022-07-012023-07-07 Journal: Veterinary pathology [Category] COVID19(2023년), [키워드] airway COVID-19 Histamine MUC5AC MUC5B Mucus obstruction. SARS-CoV-2 [DOI] 10.1177/03009858211058837 [Article Type] Review
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran ProgramCOVID-19 중증도와 관련된 유전자에 대한 페놈 전체 협회 연구에 따르면 Million Veteran Program에서 복잡한 질병과 공유된 유전학이 밝혀졌습니다.Article Published on 2022-04-282022-09-11 Journal: PLoS Genetics [Category] 변종, [키워드] ABO Affair African Analysis ancestry association Autoimmune autoimmune conditions Autoimmunity caution classification clinically complex disease condition conducted COVID-19 COVID-19 severity CRHR1 Critical Critical illness defined demonstrated determine EHR Electronic health record European fibrosis genetic architecture Genetic variant genetic variants genetics genome-wide association Genotype genotype-phenotype associations group Health health record heterogenous highlight Hispanic Hospitalization ICD immune host response increased risk inflammatory condition initiative LMNA locus Lupus mapped medical condition Million Veteran Program MUC5B MVP neutropenia Odds ratio outcome outcomes phenotype Phenotypes psoriasis pulmonary fibrosis reduced risk required reveal risk risk factor severe COVID-19 severity shared pathway stratified targets tested thrombosis Treatment TYK2 variant variants venous veteran veterans was performed with COVID-19 [DOI] 10.1371/journal.pgen.1010113 PMC 바로가기 [Article Type] Article
The MUC5B Promoter Polymorphism Associates With Severe COVID-19 in the European PopulationMedicine Published on 2021-11-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] MUC5B acute respiratory syndrome age and sex aging lung Analysis Associate association candidate gene Case-control case-control study Cohort cohorts comparable confounding variable Control coronavirus COVID-19 died Diversity European Evidence expressing expression level Frequency Genotype GWAS Hospitalization ICU Idiopathic pulmonary fibrosis innate immune response Innate immunity investigated IPF Italian Italy lung Lung disease male median age MUC5B Mucus non-infectious Patient polymorphism Population promoter provide pulmonary fibrosis recruited replicated Replication retrospective risk allele SARS-CoV-2 severe COVID-19 significantly significantly lower Spain Spanish trade-off was performed was used while with COVID-19 [DOI] 10.3389/fmed.2021.668024 PMC 바로가기 [Article Type] Medicine
Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients시스템 면역학 분석, 중증 COVID-19 환자의 면역병인 발생에 대한 폐 및 폐외 조직의 기여도 밝혀Immunology Published on 2021-06-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] activated addition Analysis APOA4 applied ASS1 B-cell B-cells BCL3 caused CBM CCL11 CD34 characterized CHI3L1 chronic inflammation complex contribute COVID-19 COVID-19 pandemic COVID-19 patient COVID19 CXCL1 cytokine cytokine production Cytokine storm Cytokines Cytokines storm DCLRE1C death dendritic cells dramatic increase dysregulated dysregulation eosinophil exacerbated Extrapulmonary extrapulmonary tissue extrapulmonary tissues Health heart heart tissue HLX HSP90AB1 IL2RA IL6 immune response immune responses immunology immunomodulatory effect Immunopathogenesis Inflammation inhibitor investigation ISG20 kidney LILRA5 liver lung lung tissue lung; modulate Monocytes MUC16 MUC17 MUC3A MUC4 MUC5B mucin multi-organ dysfunction NF-κB NF-κB signaling NFASC overexpression PARP14 potential mechanism potential mechanisms PTPN1 pulmonary resulting S100A12 SARS-CoV-2 SARS-COV-2 infection System T-cell T-cells the cytokine storm tissue tissues triggered upregulated WIPF3 [DOI] 10.3389/fimmu.2021.595150 PMC 바로가기 [Article Type] Immunology
Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity특발성 폐섬유증과 COVID-19 중증도 사이의 유전적 병인 공유Article Published on 2021-03-012022-09-11 Journal: EBioMedicine [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] airway airways Analysis association carriers causal variant characterized combined effect complex controls correlation COVID-19 COVID-19 hospitalization COVID-19 Host Genetics Initiative COVID-19 severity determine Effect estimate Evidence excluded explanation fibrosis foundation Genetic genetic association genetic determinant genetic etiology genetic risk factors genetic variants Genome-wide association study GWAS GWAS meta-analysis idiopathic Idiopathic pulmonary fibrosis increased risk initiative instrumental variable instrumental variables IPF Linkage disequilibrium lung Lung disease mendelian randomization MUC5B mucin Oak Older Older adults other variants outlier Patient performed Pneumonitis positive protective effect Protective effects provided pulmonary fibrosis risk allele risk factor risk loci risk of COVID-19 SARS-COV-2 infection scarring selection bia Selection bias Self-isolation severe COVID-19 severity survival susceptibility the strongest variance variant were used with COVID-19 [DOI] 10.1016/j.ebiom.2021.103277 PMC 바로가기 [Article Type] Article
Defensive Properties of Mucin Glycoproteins during Respiratory Infections—Relevance for SARS-CoV-2Minireview Published on 2020-11-122022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] activate acute respiratory syndrome adhesin age airway Bacterial boost clearance component Contact coronavirus Defense dependent on downregulation efficient clearance example expressed expression facilitate Factor female glycan glycans glycoprotein glycosylation Inflammatory inflammatory state Interaction Invasion ligands microbe microbial microbial infections Motile cilia MUC1 MUC16 MUC4 MUC5AC MUC5B mucin mucin-microbe interactions mucins mucosal mucosal barrier Mucus Novel coronavirus O -glycosylated O-linked glycans pathogen Pathways Prevent Proinflammatory cytokine property receptors regulated respiratory respiratory infections Respiratory pathogens respiratory tract SARS-CoV-2 sex hormone estradiol Signal transduction the healthy therapy transmembrane understanding upregulated viral infection virulence [DOI] 10.1128/mBio.02374-20 PMC 바로가기 [Article Type] Minireview
Infectivity and Progression of COVID-19 Based on Selected Host Candidate Gene VariantsGenetics Published on 2020-09-042022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] ACE2 age analyzed association can be used candidate Candidate genes CD209 clinical Cohort Comorbidities conditions COVID-19 described Exome exome data FIVE functional functional variant globe Haplotype Health help host gene identify IFITM3 in viral India individual Infection Infectivity involved management material MUC5B pathogenicity polymorphism Polymorphisms predisposition Prevalence progression Protective protocols Region reported respiratory responsible risk SARS-CoV-2 selected sequence Sex Spread Surveillance susceptible the disease TMPRSS2 Variability variant variants [DOI] 10.3389/fgene.2020.00861 PMC 바로가기 [Article Type] Genetics