Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics
Original Research
[키워드] 3D, 3-Dimensional
ASV, Amplicon sequence variant
ATP, adenosine triphosphate
CD, Crohn’s disease
CFSE, carboxyfluorescein succinimidyl ester
DI, division index
DSS, dextran sulfate sodium
ELISA, enzyme-linked immunosorbent assay
ENT, equilibrative nucleoside transporter
FSC, forward scatter
IBD, Inflammatory bowel disease
IEC, intestinal epithelial cell
IFNγ, interferon γ
IHC, immunohistochemistry
IL, interleukin
Inflammatory bowel disease
JAK inhibitor
JAK, Janus kinase
JAKi, Janus kinase inhibitor
LC-MS/MS, liquid chromatography–tandem mass spectrometry
LPS, lipopolysaccharide
M-CSF, macrophage colony-stimulating factor
mRNA, messenger RNA
Mucosal inflammation
PBMC, peripheral blood mononuclear cell
PBS, phosphate-buffered saline
PHA, phytohemagglutinin
pharmacokinetics
PI, proliferation index
STAT, signal transducers and activator of transcription
Th, T helper
TNF-α, tumor necrosis factor α
Tofacitinib
UC, ulcerative colitis
[DOI] 10.1016/j.jcmgh.2021.09.004 PMC 바로가기 [Article Type] Original Research
[DOI] 10.1016/j.jcmgh.2021.09.004 PMC 바로가기 [Article Type] Original Research