Can spike fragments of SARS-CoV-2 induce genomic instability and DNA damage in the guppy, Poecilia reticulate? An unexpected effect of the COVID-19 pandemicSARS-CoV-2의 스파이크 조각이 구피 포에실리아 망상체의 게놈 불안정성과 DNA 손상을 유발할 수 있습니까? COVID-19 전염병의 예상치 못한 영향Article Published on 2022-06-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] animals Brain Can catalase correlated COVID-19 COVID-19 pandemic demonstrated dismutase dispersal DNA damage ecosystem Effect ENA evaluate Frequency Freshwater fish gel electrophoresis genomic genotoxic genotoxicity Impact increase in induce knowledge lipid peroxidation liver malondialdehyde mutagenic Mutagenicity New coronavirus nuclear Olive Organisms parameter peptide peptides Protein raised reduction reported SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles significantly Single Cell Spike protein Superoxide Superoxide Dismutase tail the Spike Toxicity Viral particles water Water pollution [DOI] 10.1016/j.scitotenv.2022.153988 PMC 바로가기 [Article Type] Article
The Use of In Silico Tools for the Toxicity Prediction of Potential Inhibitors of SARS-CoV-2SARS-CoV-2의 잠재적 억제제의 독성 예측을 위한 In Silico 도구의 사용Article Published on 2021-04-122022-09-10 Journal: Alternatives to Laboratory Animals [Category] MERS, 신약개발, 치료법, 치료제, [키워드] in silico toxicology adverse effects approval assist carcinogenicity Cardiotoxicity chymotrypsin Compound compounds computational toxicology Consensus Convalescent plasma therapy coronavirus coronavirus disease COVID-19 cysteine cysteine protease drug Drug development effort Endpoint exhibited hepatotoxicity in silico inhibitor inhibitors lead limitations Mutagenicity nucleocapsid protein positive Potential predict predicted prediction profiles protease Regulatory reported Repurposed drugs repurposing SARS-CoV-2 severe adverse effect silico studies therapeutic intervention Toxicity toxicity prediction were assessed were used [DOI] 10.1177/02611929211008196 PMC 바로가기 [Article Type] Article