The mef(A)/ msr(D)-carrying streptococcal prophage Φ1207.3 encodes an SOS-like system, induced by UV-C light, responsible for increased survival and increased mutation ratemef(A)/msr(D)를 지닌 연쇄상구균 프로파지 Φ1207.3는 UV-C 빛에 의해 유도되는 SOS 유사 시스템을 인코딩하며, 이는 생존율 증가와 돌연변이율 증가에 책임이 있다.Article Published on 2023-09-262024-08-24 Journal: Retinal cases & brief reports [Category] 폐렴구균 감염증, [키워드] bacterial survival DNA repair fluctuation test mef(A)/msr(D) mutation rate prophage S. pneumoniae S. pyogenes SOS response UV-C LED light Φ1207.3.
Phylogenomic and Structural Analysis of the Monkeypox Virus Shows Evolution towards Increased StabilityArticle Published on 2022-12-312023-06-09 Journal: Viruses [Category] Fulltext, 원숭이두창, [키워드] high mutation Monkeypox virus mutation rate Phylogenomics protein structure [DOI] 10.3390/v15010127 PMC 바로가기
Antibody response and intra-host viral evolution after plasma therapy in COVID-19 patients pre-exposed or not to B-cell-depleting agentsArticle Published on 2022-11-012022-11-15 Journal: British Journal of Haematology [Category] SARS, 진단, [키워드] anti-CD20 anti-CD20 therapy Anti-spike anti-Spike IgG antibody antibody kinetics B-cell clinical care clinical status clinical symptom Complete contribute convalescent convalescent plasma COVID-19 patient Decline donors eligible evaluated Follow-up hospitalized COVID-19 patients humoral Humoral immunity IgG Immune escape Immunocompromised Immunocompromised patients Immunoglobulin impair lymphopenia majority management mRNA-based vaccine mRNA-based vaccine plasma mutation rate Patient patients treated plasma receiving SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2-specific antibodies severity spike mutations survival therapy titre viral control viral evolution virus clearance WHO whole-genome sequencing World Health Organization [DOI] 10.1111/bjh.18450 PMC 바로가기
The Rise and Fall of SARS-CoV-2 Variants and Ongoing Diversification of OmicronArticle Published on 2022-09-102022-11-16 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] BA.4 BA.5 conserved Course COVID-19 Critical effort elevated etiological agent Evolution Genetic High-throughput sequencing technology involved mutation rate Nucleocapsid proteins omicron pandemic Randomly Replication Retrospective analysis SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants selected selective pressure Sequencing significantly Spread subset Surveillance variant variants of concern Viral surveillance virus VOCs [DOI] 10.3390/v14092009 PMC 바로가기
SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.22021년 9월부터 11월까지 영국의 SARS-CoV-2 계보 역학: Delta 하위 계통의 높은 다양성과 AY.4.2의 전파 가능성 증가Article Published on 2022-07-272022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI assessment Clustering Community community transmission country COVID-19 COVID-19 symptom Delta delta variant endemicity England exhibiting genetic diversity genomic data Genomic surveillance greater immune Immune escape Immunity increases in individual introduced less Lineage lineages Mutation mutation rate natural infection no symptom no symptoms nose swab Phylogenetic relationship positive individuals Predictive prevalent lineage proportion provided random reduced reduction in Region reported Reproduction number RT-PCR testing SARS-CoV-2 SARS-CoV-2 lineage South study period surveillance data symptom status symptomatic individuals Transmissibility Transmission advantage unique vaccination variant virus [DOI] 10.1186/s12879-022-07628-4 PMC 바로가기 [Article Type] Article
Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution DynamicsRBD 오미크론 돌연변이 및 SARS-CoV-2 진화 역학과 관련된 면역 탈출Review Published on 2022-07-222022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] absence Affect appearance bioinformatics COVID-19 COVID-19 pandemic described Dynamics escape Evolution explained Features Genome high affinity high mutation rate Host immune Immune escape Lineage Mutation mutation rate natural immunity omicron pathogenicity Protein RBD RBD mutations receptor SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 strains serotype Spike protein the Spike therapeutic therapeutic agent therapeutic agents Transmissibility Vaccine Vaccine development variant virus [DOI] 10.3390/v14081603 PMC 바로가기 [Article Type] Review
Favipiravir and/or nitazoxanide: a randomized, double-blind, 2×2 design, placebo-controlled trial of early therapy in COVID-19 in health workers, their household members, and patients treated at IMSS (FANTAZE)Favipiravir 및/또는 nitazoxanide: IMSS(FANTAZE)에서 치료를 받는 의료 종사자, 가족 구성원 및 환자를 대상으로 한 COVID-19 조기 치료에 대한 무작위, 이중 맹검, 2x2 설계, 위약 대조 시험Randomized Controlled Trial Published on 2022-07-222022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 1:1 2×2 design absence Admission antimicrobial Antimicrobials Antiviral effect antiviral therapy Antiviral treatment antivirals appear assigned Asymptomatic blinded to treatment combination therapy Comorbidities Comorbidity Controlled trial COVID-19 COVID-19 disease disease double-blind early disease early phase early treatment example Favipiravir followed by Gender Genetic genetic mutation Health high risk Hospitalization Hypothesis in some include individuals Infection Inflammatory Influenza intensive care investigator investigators later phase morbidity and mortality Mutation mutation rate nitazoxanide obesity older patient outcome pandemic participant patients treated pharmacokinetics phase phase IIa Placebo placebo-controlled placebo-controlled clinical trial placebo-controlled trial positive presence or absence Prevent Primary outcome progression protocol randomised randomised controlled trial Randomized receive replicates SARS-CoV-2 secondary Secondary outcomes security Sepsis severe disease smoking status Social Security Stratification symptomatic symptomatic COVID-19 Symptoms tested the disease therapy those with comorbidity Toxicity treatment allocation Trial upper respiratory tract Viral load virus [DOI] 10.1186/s13063-022-06533-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Host-Genome Similarity Characterizes the Adaption of SARS-CoV-2 to Humans숙주-게놈 유사성은 SARS-CoV-2의 인간 적응을 특징짓는다Article Published on 2022-07-122022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptability Alpha Analysis Beta coronavirus correlation dataset Delta delta variant evade evade immunity FIVE Frame Gamma Genome genomes help HGS high mutation rate highest Host host genome host genome similarity host innate immunity Human IFN-β immune system Immunity in vivo Indicator Innate immunity Interaction lowest mechanism Mutation mutation rate omicron Omicron variants Open reading frame ORF populations puzzle SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus shown signaling pathway similarity strain suppression variant variants viral genomes [DOI] 10.3390/biom12070972 PMC 바로가기 [Article Type] Article
Rampant C-to-U deamination accounts for the intrinsically high mutation rate in SARS-CoV-2 spike geneArticle Published on 2022-07-012023-07-09 Journal: RNA (New York, N.Y.) [Category] COVID19(2023년), [키워드] C-to-U deamination mutation rate S gene SARS-CoV-2 single-stranded RNA. [DOI] 10.1261/rna.079160.122
Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13SARS-CoV, SARS-CoV-2 및 박쥐 코로나바이러스 RaTG13의 게놈 간의 삽입 및 삭제 돌연변이Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 base bases bat bat coronavirus RaTG13 Complete coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) developmental distribution FIVE Frame gene sequence Genome genome sequence Genome sequences genomes Inconclusive INDEL indels insertion insertion-and-deletion mutation mechanism MOST Mutation mutation rate mutations Noncoding region nonstructural protein 3 Open reading frame ORF ORF8 ORF8 gene ORF8 genes Point mutation point mutations protein 3 RaTG13 replaced REPLACED BY replacement S1 domain SARS-CoV SARS-CoV-2 SARS-CoV-2 genome sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus (SARS-CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein the SARS-CoV-2 genome the spike protein viral genome virus [DOI] 10.1128/spectrum.00716-22 PMC 바로가기 [Article Type] Article