Single-Cell RNA Sequencing Reveals Immunomodulatory Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor Treatment in the Brains of Aged APP/PS1 MiceArticle Published on 2024-07-102024-09-05 Journal: Biomolecules [Category] update2024, [키워드] Alzheimer’s disease hematopoietic growth factors macrophages microglia myeloid cells S100A8 S100A9 Single-cell RNA sequencing [DOI] 10.3390/biom14070827 PMC 바로가기 [Article Type] Article
Epigenetic modulation of myeloid cell functions in HIV and SARS-CoV-2 infectionReview Published on 2024-02-242024-09-05 Journal: Molecular biology reports [Category] update2024, [키워드] AIDS COVID-19 epigenetics HIV myeloid cells SARS-CoV-2 [DOI] 10.1007/s11033-024-09266-2 PMC 바로가기 [Article Type] Review
Acellular Human Amniotic Fluid-Derived Extracellular Vesicles as Novel Anti-Inflammatory Therapeutics against SARS-CoV-2 InfectionArticle Published on 2024-02-092024-09-05 Journal: Viruses [Category] update2024, [키워드] acAF AF-EVs Cytokine storm dysregulated immunity MA-CoV-2 myeloid cells [DOI] 10.3390/v16020273 PMC 바로가기 [Article Type] Article
Neutrophil responsiveness to IL-10 impairs clearance of Streptococcus pneumoniae from the lungsIL-10에 대한 호중구의 반응성이 폐에서 폐렴구균의 제거를 저해한다.Article Published on 2024-01-052024-08-24 Journal: Journal of Leukocyte Biology [Category] 폐렴구균 감염증, [키워드] Anti-inflammatory Cytokines host-pathogen interactions IL-10 IL-10R immune evasion Lung infection myeloid cells Neutrophils Pneumonia pulmonary Streptococcus pneumoniae
Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cellsImmunology Original Research Published on 2023-12-182024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] immune checkpoint inhibitor (ICI) myeloid cells nanobodies (Nbs) PET imaging tracer SIRPalpha theranostics [DOI] 10.3389/fimmu.2023.1264179 PMC 바로가기 [Article Type] Immunology Original Research
Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelinationarticle Published on 2023-07-122024-09-05 Journal: Acta Neuropathologica Communications [Category] update2024, [키워드] B cells Demyelination experimental autoimmune encephalomyelitis microglia multiple sclerosis myeloid cells Secondary progressive [DOI] 10.1186/s40478-023-01614-w PMC 바로가기 [Article Type] article
Type I interferon receptor signalling deficiency results in dysregulated innate immune responses to SARS-CoV-2 in miceArticle Published on 2022-11-012023-07-10 Journal: European Journal of Immunology [Category] COVID19(2023년), [키워드] in vivo innate immune response myeloid cells SARS-CoV-2 Type I IFN [DOI] 10.1002/eji.202249913 PMC 바로가기
Single-Cell Gene Expression Analysis Revealed Immune Cell Signatures of Delta COVID-19Article Published on 2022-09-212022-11-16 Journal: Cells [Category] SARS, 변종, 유전자 메커니즘, [키워드] accompanied accompany adaptive B.1.617 Blood caused Characteristics contribute coronavirus disease correlated COVID-19 COVID-19 pathogenesis Cytokine storm Delta delta variant diagnostic dominant Factor Gene Expression gene expression signature high mortality highlight immune immune component immune response immune system Immunity immunological individual Infection Lineage lymphoid molecular monocyte Monocytes mononuclear cell Multiple myeloid cells pathway performed proinflammatory required Revealed risk SARS-CoV-2 SARS-CoV-2 lineage severity signature significant changes in single-cell syndrome targeted therapy therapeutic Transcriptome understanding variant virus with COVID-19 [DOI] 10.3390/cells11192950 PMC 바로가기
Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages고도로 제한된 SARS-CoV-2 수용체 발현 및 1차 인간 단핵구 및 단핵구 유래 대식세포에 의한 감염에 대한 내성Article Published on 2022-09-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cause caused cellular cellular receptor condition contribute coronavirus COVID-19 Defense direct infection enzyme Express expression facilitated global pandemic immune activation in vitro Infection involved Macrophage macrophages MDM mechanism monocyte monocyte-derived macrophage Monocyte-derived macrophages Monocytes myeloid cell myeloid cells occur Pathogenesis primary human monocyte priming pseudotyped virions receptor remained resistance to infection SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV2 SARS-CoV2 infection Severe acute respiratory syndrome severity spike subtype the disease TMPRSS2 unlikely unpolarized viral spike [DOI] 10.1002/JLB.4COVA1121-579RR PMC 바로가기 [Article Type] Article
Host and microbiome features of secondary infections in lethal covid-19Research article Published on 2022-08-132022-10-05 Journal: iScience [Category] 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] alteration Bacterial C1q cause cellular complement contribute Control DAD death Defense Diffuse alveolar damage dominant driving Factor feature fungal pathogen highlight Immunity immunology inhibitory lethal lung lung tissue Macrophage microbial Microbiome Mortality myeloid cells organ pandemic pathology pathophysiological reduced RNA-Seq SARS-COV-2 infection Secondary infection secondary infections significantly stratified subgroup Virology [DOI] 10.1016/j.isci.2022.104926 [Article Type] Research article