Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis시간 순서 Transcriptomic 분석을 기반으로 한 다발성 장기 기능 장애의 분자 메커니즘 및 COVID-19의 표적 개입Immunology Published on 2021-08-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] acetaminophen Activation addition Algorithm Angiogenesis B2M BFS algorithm Bioinformatics analysis biological process biological processe biological processes Brain caused CD40 CD40LG cell-mediated immune cell-mediated immune response changes in Comparative Compound Coronavirus disease 2019 COVID-19 CSF1 Curcumin CXCL10 cytokine Cytokine storm database defined determine Dexamethasone DNA downloaded drug energy metabolism enrichment analysis FCER1G FIVE gene co-expression network Gene Expression gene expression profile Gene expression profiles Gene ontology Genes heterogeneous high mortality hub genes ICAM1 identify immune gene immune response Immunity initial gene IRF7 LAT Lcn2 lead leukocyte lung metabolism molecular mechanism morphology Multiple multiple organ dysfunction multiple organ heterogeneity myeloid leukocyte neuronal Novel coronavirus olfactory organ organs other compound PageRank pandemic pattern PLAU predicted protein metabolism Protein–protein interaction Regulation Research response resveratrol RHOA rRNA second Spread SRC statins Stress stress response targeted intervention the cytokine storm TNFRSF1A TO-GCN Toxicogenomics Trachea tracheal Transmission Treatment unique was performed was used [DOI] 10.3389/fimmu.2021.729776 PMC 바로가기 [Article Type] Immunology
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19COVID-19 환자에서 MAIT 세포의 단일 세포 전사체 프로파일링Immunology Published on 2021-07-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome adaptive addition Analysis analyzed Apoptosis apoptotic cause Cell cell cytotoxicity cell death cells cellular chemotaxis coronavirus COVID-19 cytometry analysis DEGs differentially expressed gene Differentially expressed genes disease severity Flow Flow cytometry analysis frequencies Frequency healthy donors highest Host immune response humoral immune response immune immune responses indicated involved killing leukocyte lymphocyte MAIT moderate myeloid leukocyte Pathogenesis Patient patients with COVID-19 performed Profiling provide pyroptosis respiratory Result SARS-CoV-2 SARS-COV-2 infection Severe case severe cases severe disease significantly single-cell Single-cell RNA sequencing T-cell receptor the disease transcriptional profile transcriptomic transcriptomic data [DOI] 10.3389/fimmu.2021.700152 PMC 바로가기 [Article Type] Immunology