Treatment with quercetin inhibits SARS-CoV-2 N protein-induced acute kidney injury by blocking Smad3-dependent G1 cell-cycle arrestArticle Published on 2023-02-012023-07-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), [키워드] AKI G1 cell-cycle arrest N protein P16 quercetin. SARS-CoV-2 Smad3 [DOI] 10.1016/j.ymthe.2022.12.002 PMC 바로가기
Production of a Monoclonal Antibody to the Nucleocapsid Protein of SARS-CoV-2 and Its Application to ELISA-Based Detection Methods with Broad Specificity by Combined Use of Detector AntibodiesArticle Published on 2022-12-212023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] COVID-19 ELISA monoclonal antibody N protein SARS-CoV-2 variants. [DOI] 10.3390/v15010028 PMC 바로가기
Self-Reported Long COVID and Its Association with the Presence of SARS-CoV-2 Antibodies in a Danish Cohort up to 12 Months after InfectionArticle Published on 2022-12-212023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] antibodies Long COVID N protein nucleocapsid antigen PASC post-acute-phase COVID-19 post-COVID syndrome Prolonged COVID. SARS-CoV-2 SARS-CoV-2 antibodies [DOI] 10.1128/spectrum.02537-22 PMC 바로가기
An Electrochemical Immunosensor Based on Carboxylated Graphene/SPCE for IgG-SARS-CoV-2 Nucleocapsid DeterminationArticle Published on 2022-12-132023-07-11 Journal: Biosensors [Category] COVID19(2023년), [키워드] immunosensor. N protein SARS-CoV-2 [DOI] 10.3390/bios12121161 PMC 바로가기
Production of single-cycle infectious SARS-CoV-2 through a trans-complemented repliconArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome approach BAC Cell cells clone coated Coronavirus-2 COVID-19 culture supernatant did not produce elicit expression generate IFN immune response infected cell Infection Infectious virus Live attenuated vaccine memory N protein nucleocapsid omicron overexpression plaques platform Production progeny provide Replication replicon rescued resulting RNA robust S protein SARS-CoV-2 single-cycle infectious virus. Strains transient expression transmission electron microscopy type I interferon Vaccine Viral RNA virion virus [DOI] 10.1002/jmv.28057 PMC 바로가기
Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptorArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals binding C-terminal domain cell cultures compounds coronavirus Critical CTD disrupt Genome identify information isothermal titration calorimetry Ligand ligands N protein N-protein NMR nucleocapsid Protein reduced representing RNA SARS-CoV-2 nucleocapsid SARS-CoV-2 replication small molecule the N protein the SARS-CoV-2 the SARS-CoV-2 genome Transcription [DOI] 10.1038/s41598-022-22576-4 PMC 바로가기
Smartphone-Based Electrochemical Immunoassay for Point-of-Care Detection of SARS-CoV-2 Nucleocapsid ProteinArticle Published on 2022-11-012022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] antibody bovine calculated coated with Concentration detection detection efficiency diagnose Diagnosis effective electron transfer facilitate immunoassay lack less limit of detection linear N protein nucleocapsid protein offer point-of-care provided R 2 reduced reducing reported resulting SARS-CoV-2 SARS-CoV-2 N protein serological serum albumin the SARS-CoV-2 transmitted virus transmission [DOI] 10.1021/acs.analchem.2c03606 PMC 바로가기
In silico characterization of mutations circulating in SARS-CoV-2 structural proteinsArticle Published on 2022-11-012022-11-16 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] Algorithm Analysis caused circulating computational approach computational tool COVID-19 D614G death Deleterious discrete molecular dynamics DMD envelope protein full-length identify infections meta-data molecular molecular simulations mutant Mutation mutations N protein Neutral NMA non-structural protein normal mode analysis Nsp3 nucleocapsid nucleocapsid protein pandemic predicted Protein protein coding gene protein stability Proteins RdRP RNA-directed RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence Seven Spike protein stability structural protein suggested utilised viral dynamics viral genome viral pathogenicity Viral pathogenicity. [DOI] 10.1080/07391102.2021.1908170 PMC 바로가기
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylationArticle Published on 2022-11-012023-07-10 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), [키워드] N protein nucleocapsid Nucleosome Phosphorylation plus-stranded RNA virus. RNA binding protein RNA virus SARS-CoV-2 [DOI] 10.1016/j.jbc.2022.102560 PMC 바로가기
A Rapid SARS-CoV-2 Nucleocapsid Protein Profiling Assay with High Sensitivity Comparable to Nucleic Acid DetectionArticle Published on 2022-10-252022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acid Antigen binding caused Concentration COVID-19 COVID-19 diagnosis detection DNA effective ELISA kits Epidemic Epidemics information limit of detection magnitude N protein nucleic acid nucleocapsid protein PCR Profiling Protein Rapid Region resulting Saliva SARS-CoV-2 sensitivity target protein The fluorescence intensity the N protein translation [DOI] 10.1021/acs.analchem.2c02670 PMC 바로가기