Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China
C5178a 및 A249d/T6392C/G10310A의 일반적인 mtDNA 변이는 중국 중부의 한족 인구에서 심각한 COVID-19의 위험을 감소시킵니다
Research
[키워드] 95% CI
95% confidence interval
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
age
Analysis
association
calculate
cardiopulmonary diseases
categorical variables
chest X-ray
China
CIs
common
Computed tomography
conducted
confounding factor
continuous variables
contribute
Control
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 patient
COVID-19 patients
Cytochrome C
cytochrome c oxidase
D-loop
decrease
determine
diabetes
diagnosed
diagnostics
disease
distribution
DNA
exclusion criteria
Fisher’s exact test
Han Chinese
healthy control
healthy controls
hypertension
increased risk
independent
Infection
investigated
Logistic regression
Logistic regression analyses
Mitochondria
mitochondrial
mitochondrial DNA
molecular
molecular diagnostics
MtDNA variations
multivariate
multivariate logistic regression
NADH
ND1
ND2
ND3
obesity
Odds ratio
Odds ratios
oxidative phosphorylation
oxygen
performed
Phylogenetic analysis
qPCR
radiographic examinations
reactive oxygen specy
reduced risk
respiratory
Result
risk
SARS-CoV-2
Sequencing
severe acute respiratory syndrome Coronavirus
severe COVID-19
Sex
shown
smoking
Student’s t -test
subunit
supplementary material
the healthy
variables
variant
variants
Variation
Viral
viral genome
vital role
vital roles
was used
with COVID-19
[DOI] 10.1186/s40779-021-00351-2 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s40779-021-00351-2 PMC 바로가기 [Article Type] Research