Surrogate Virus Neutralisation Test Based on Nanoluciferase-Tagged Antigens to Quantify Inhibitory Antibodies against SARS-CoV-2 and Characterise Omicron-Specific Reactivity in a Vaccination CohortArticle Published on 2023-12-082024-09-05 Journal: Vaccines [Category] update2024, [키워드] antibody quantification nanoluciferase Omicron BA.1 pseudotyped virus neutralisation test SARS-CoV-2 surrogate virus neutralisation test vaccination study [DOI] 10.3390/vaccines11121832 PMC 바로가기 [Article Type] Article
Protein A-Nanoluciferase fusion protein for generalized, sensitive detection of immunoglobulin GArticle Published on 2023-01-012023-07-10 Journal: Analytical biochemistry [Category] COVID19(2023년), [키워드] bioluminescence IgG detection immunoassay nanoluciferase protein A SARS-CoV-2 nucleoprotein [DOI] 10.1016/j.ab.2022.114929 PMC 바로가기
Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-outarticle Published on 2022-09-302024-09-01 Journal: SLAS Discovery [Category] 말라리아, [키워드] Drug discovery High Throughput Screening malaria nanoluciferase Phenotypic screen Screening cascade [Article Type] article
Detecting SARS-CoV-2 neutralizing immunity: highlighting the potential of split nanoluciferase technologySARS-CoV-2 중화 면역 검출: 분할 나노루시페라제 기술의 잠재력 강조Review Published on 2022-08-172022-09-11 Journal: Journal of Molecular Cell Biology [Category] SARS, 변종, 진단, 치료기술, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 biosafety coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect focus gold gold standard Health highlighting hour humoral immune Immune escape immune escape mutants Immunity immunity passport individual individual variations Infection mass vaccination nanoluciferase neutralization test Neutralizing Neutralizing antibodies neutralizing antibody pandemic plaque reduction neutralization progressed pros PROTECT protective antibodies Protective antibody protective immunity respiratory SARS-CoV-2 SARS-CoV-2 neutralizing antibodies severe acute respiratory syndrome Coronavirus split nanoluciferase subsequent surrogate virus neutralization test titers vaccination Variation Virus neutralization virus-like particles [DOI] 10.1093/jmcb/mjac023 PMC 바로가기 [Article Type] Review
Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2막 융합을 방해하는 화합물을 식별하기 위해 광범위하게 적용 가능한 바이러스 없는 이중 보고자 분석: HSV-1 및 SARS-CoV-2에 대한 성능Article Published on 2022-06-212022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] alkaline alkaline phosphatase antiviral agent Antiviral agents cell-cell fusion cell–cell fusion Compound doxycycline dual reporter assay Efficacy enzyme expressed expression fluorescent fusion inhibition HSV-1 identify inhibitors Internal control marker membrane fusion nanoluciferase nuclear Pathogens performance phosphatase quantification Replication reported reporter reporter fusion reporter gene SARS-CoV-2 secreted secreted alkaline phosphatase secreted nanoluciferase. Sensitivity and specificity Tetracycline transient transfection Vero Cell Vero cells viral pathogens was tested [DOI] 10.3390/v14071354 PMC 바로가기 [Article Type] Article
Clinical Utility of Elecsys Anti-SARS-CoV-2 S Assay in COVID-19 Vaccination: An Exploratory Analysis of the mRNA-1273 Phase 1 TrialCOVID-19 백신 접종에서 Elecsys Anti-SARS-CoV-2 S 어세이의 임상적 유용성: mRNA-1273 1상 시험의 탐색적 분석Clinical Trial Published on 2022-01-192022-09-11 Journal: Frontiers in Immunology [Category] 임상, 치료기술, [키워드] 2019-nCoV absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-SARS-CoV-2 S antibody antibody levels automated baseline choice clinical clinical utility collected coronavirus correlated correlation COVID-19 Day detectable dose Elecsy ELISA ELISAs first vaccination geometric mean geometric mean concentration healthy heterogeneous humoral immune response increases in injection International international standard mRNA mRNA-1273 nanoluciferase neutralization test neutralization tests Neutralizing antibodies participant Participants Phase 1 phase 1 trial Protein pseudovirus neutralizing antibody pseudovirus neutralizing antibody assay quantification Quantitative quantitative serology RBD RBD ELISA RBD-specific antibodies RBD-specific antibody Receptor binding domain respiratory Result Roche S-2P Sample SARS-CoV-2 second vaccination Seroconversion seroconverted severe acute respiratory syndrome Coronavirus shown specific antibodies specificity Spike protein the Spike U/mL vaccination Vaccine vaccine-induced antibody response WHO [DOI] 10.3389/fimmu.2021.798117 PMC 바로가기 [Article Type] Clinical Trial
Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and ReplicationArticle Published on 2022-01-182022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] A97V antiviral activity autonomous BAC Bacterial Cell culture chromosome clone coronavirus COVID-19 COVID-19 pandemic decrease drug Efficacy exhibited experiments F480L facilitated fluorescent full-length SARS-CoV-2 functional Genes genomic region genomic RNA GFP growth Healthcare system in vitro Infectious virus inhibited membrane modify molecular clone Mutation nanoluciferase non-infectious Nsp12 P323L phenotype platform polymerase polymorphism Protein provide recombinant Remdesivir Replication replicon reporter Research resistance RNA virus SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 susceptibility SARS-CoV-2 variants sequence Substitution susceptibility System transcript Treatment utility Vaccines Vero E6 cell viral gene virus virus isolate [DOI] 10.3390/v14020172 PMC 바로가기 [Article Type] Article
Construction, Characterization and Application of Recombinant Porcine Deltacoronavirus Expressing NanoluciferaseArticle Published on 2021-10-042022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] accelerate Antiviral antiviral drug antivirals application Bacterial cause cell line cell tropism cells Characteristics characterization chromosome clone Combination construction coronavirus Cross-species transmission diarrhoea drugs effective exhibited expressing genetics growth Homologous recombination Host in vitro nanoluciferase parental Porcine deltacoronavirus quantification recombinant replacing Replication reporter reporter virus resveratrol susceptibility Vaccine virus [DOI] 10.3390/v13101991 PMC 바로가기 [Article Type] Article
Construction of a Recombinant Porcine Epidemic Diarrhea Virus Encoding Nanoluciferase for High-Throughput Screening of Natural Antiviral ProductsArticle Published on 2021-09-182022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] antioxidant antioxidants Antiviral compounds approved drug caffeic acid Cell clone Compound compounds construction contagious disease dose-dependent manner encoding epidemic diarrhea exhibited expected expressing expression Frame full-length cDNA genetics growth High-throughput screening identify in vitro Infection inhibit lithocholic acid luciferase activity morphology nanoluciferase natural Neonatal nLuc ORF3 oxygen PEDV platform positive correlation predominant produced product recombinant reduce replaced Replication Reverse genetics system screened Screening significantly therapeutic compound turn viral genome virus wild-type [DOI] 10.3390/v13091866 PMC 바로가기 [Article Type] Article
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy생쥐에서 SARS-CoV-2 감염의 실시간 영상은 중화 항체가 최적의 효능을 위해 Fc 기능을 필요로 함을 보여줍니다Article Published on 2021-09-142022-09-11 Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] addition Administered antibody applied bioluminescence imaging BLI Brain convalescent COVID-19 death Effect effective Efficacy Fab Fc effector functions Fc function function hACE2 highlight human ACE2 human ACE2 transgenic mice immune protection immunopathology in vivo indicated Infection Inflammatory response Inflammatory responses Interaction intranasally K18-hACE2 mice limit lung Lungs mechanism mice MONITOR Monocytes NAb NAbs nanoluciferase nasal Nasal cavity natural killer natural killer cell Natural killer cells neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutrophils organ Pathogenesis prevented Prophylaxis required resolved reveal SARS-CoV-2 SARS-COV-2 infection subject systemically therapy transgenic treating COVID-19 Treatment virus spread [DOI] 10.1016/j.immuni.2021.08.015 PMC 바로가기 [Article Type] Article