From intramuscular to nasal: unleashing the potential of nasal spray vaccines against coronavirus disease 2019Reviews Published on 2024-05-202024-09-05 Journal: Clinical & Translational Immunology [Category] update2024, [키워드] COVID‐19 Immunity Nasal cavity SARS‐CoV‐2 Vaccine [DOI] 10.1002/cti2.1514 PMC 바로가기 [Article Type] Reviews
Lipid nanoparticle formulations for optimal RNA-based topical delivery to murine airwaysArticle Published on 2022-09-012023-07-09 Journal: European journal of pharmaceutical sciences : offi [Category] COVID19(2023년), [키워드] airway epithelial cells Lipid nanoparticles mRNA Nasal cavity siRNA [DOI] 10.1016/j.ejps.2022.106234
Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic EpipharyngitisEpipharyngeal Abrasive Therapy(EAT)는 만성 인두염에서 주요 전염증성 사이토카인 IL-6의 mRNA 발현을 감소시킵니다Article Published on 2022-08-162022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] Abrasive addition aggregation Alpha analyzed anti-inflammatory effect Cell chronic chronic fatigue syndrome chronic inflammation contribute cough COVID cytokine cytokine network Cytokines Diseases effective epipharyngeal abrasive therapy (EAT) epipharyngitis epipharynx expression expression pattern fatigue fatigue syndrome Hypothesis IgA IgA nephropathy IL-6 IL-6 expression IMPROVE In situ hybridization induce Inflammatory cytokine Inflammatory cytokines Inflammatory diseases interleukin interleukin 6 interleukin 6 (IL-6) intractable involved Japan Local Long Long COVID Major mechanisms mRNA myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) nasal Nasal cavity Necrosis nephropathy Patient postnasal drip Proinflammatory cytokine reduced reported responsible Sedation significantly lower subject suggested suppressed suppression Symptom syndrome systemic inflammatory disease systemic inflammatory diseases systemic symptoms therapy TNFα treated Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha tumor necrosis factor alpha (TNFα). upper respiratory tract [DOI] 10.3390/ijms23169205 PMC 바로가기 [Article Type] Article
Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial호흡기 감염 감소를 위한 아스토드리머 나트륨 항바이러스 비강 스프레이는 무작위 대조 시험에서 안전하고 내약성이 우수합니다.Randomized Controlled Trial Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] absorbed Absorption Administered administration adverse event All participants Antiviral applied clinical clinical investigation clinical trial clinically Cohort Community community acquired dendrimer double-blinded Effects examination finding examination findings exploratory exposure to followed by four times daily Frequency healthy volunteer help in vitro Infection initial intensity Intensive Mild nasal Nasal cavity nasal mucosa Nasal spray New nostril occurred other respiratory virus Other respiratory viruses participant Placebo placebo-controlled primary endpoint product Randomized Randomized controlled trial receiving reduce reducing Registered registry respiratory infection respiratory virus Respiratory virus infections respiratory viruses Safe safety population SARS-CoV-2 serious AEs severity shown sodium spray Spread systemically TEAE TEAEs Tolerability Treatment Trial registration utility vaginal mucosa Viral load virucidal Withdrawal [DOI] 10.1038/s41598-022-14601-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Performance evaluation of STANDARD Q COVID-19 Ag home test for the diagnosis of COVID-19 during early symptom onsetSTANDARD Q COVID-19 Ag 가정검사로 초기 증상 발현 시 COVID-19 진단 성능 평가Article Published on 2022-06-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 치료기술, [키워드] Antigen Asymptomatic Chain Reaction confidence interval confirmation COVID-19 COVID-19 patient COVID-19 testing criterion Ct value Ct values decrease Diagnosis diagnosis of COVID-19 early phase enrolled gold gold standard home nasal Nasal cavity Nasopharyngeal swab nasopharyngeal swab specimen no difference outbreak Outbreaks P-value Patient performance point of care polymerase chain polymerase chain reaction real-time polymerase chain reaction RT-PCR SARS-CoV-2 SD Biosensor sensitivity significantly higher specificity specimen symptom onset symptomatic patient Symptomatic patients Symptoms Test was collected [DOI] 10.1002/jcla.24410 PMC 바로가기 [Article Type] Article
Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2레플리콘 기반 mRNA 백신 후보의 박테리아 지원 경구 전달은 조상 및 델타 변이형 SARS-CoV-2로부터 보호Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphaviruses antibody antigenic diversity B.1.617.2 Bacteria Cellular immune response cellular immune responses clade contributed contributing to Coronavirus-2 COVID-19 cross-protective domain Efficacy epitope Epitopes Evolution feasible forest gene delivery hamster hamsters heptad repeat immune responses immunization immunized immunized mice Immunoglobulin lung Lungs mass vaccination membrane protein mRNA mRNA vaccine mucosal mucosal vaccine NAbs nasal Nasal cavity Neutralizing antibodies neutralizing antibody non-structural protein nsp13 offer oral Oral Immunization oral route Pneumonia principle PROTECT provide RBD Receptor binding domain recorded replicon-based respiratory Salmonella Salmonella-mediated SARS-CoV-2 secretory IgA SIgA the vaccine vaccination Vaccine vaccine efficacy variant variants Viral viral replication virus [DOI] 10.1016/j.ymthe.2022.01.042 PMC 바로가기 [Article Type] Article
Hamsters Expressing Human Angiotensin-Converting Enzyme 2 Develop Severe Disease following Exposure to SARS-CoV-2Article Published on 2022-02-222023-07-07 Journal: mBio [Category] COVID19(2023년), [키워드] angiotensin-converting enzyme 2 cardiac lesions K18-hACE2 Nasal cavity Neuropathology olfactory bulb SARS-CoV-2 transgenic hamsters. [DOI] 10.1128/mbio.02906-21 PMC 바로가기
The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamstersB.1.427/1.429(엡실론) SARS-CoV-2 변종은 시리아 햄스터의 조상 B.1(614G)보다 더 치명적입니다.Research Article Published on 2022-02-102022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition airway airways Alpha animal models Antibody neutralization B.1 B.1.1.7 B.1.351 B.1.427 B.1.429 Beta body weight Body weight loss Brazil Clinical data convalescent patient Convalescent patients Critical determine dissemination Efficiency Epsilon evade experiments explain hamster hamsters help highest Human human population in vitro India Infection infections late stage lineages lung Lungs maintain moderate nasal Nasal cavity New observé oral swab oral swabs Oropharyngeal oropharynx P.1 P.2 parenchyma plasma pre-existing immunity recipients replicate Replication SARS-CoV-2 variant SARS-CoV-2 variants severe disease severe lung pathology sgRNA shown significant difference significant differences South Africa Spread susceptibility Transmissibility Transmission Vaccine Vaccine-induced immunity variant variants variants of SARS-CoV-2 Viral Viral RNA virulence virulent weight loss Zeta [DOI] 10.1371/journal.ppat.1009914 PMC 바로가기 [Article Type] Research Article
Hydroxypropyl Methylcellulose-Based Nasal Sprays Effectively Inhibit In Vitro SARS-CoV-2 Infection and Spread하이드 록시 프로필 메틸 셀룰로스 기반 비강 스프레이는 시험 관내 SARS-COV-2 감염을 효과적으로 억제하고 확산Communication Published on 2021-11-232022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antiviral property appear causative agent Cell Cell culture coronavirus coronavirus disease COVID-19 dose dose-dependent manner form Garlic gel HPMC hydroxypropyl methylcellulose in some in vitro independent independent of infected with SARS-CoV-2 Infection inhibit SARS-CoV-2 inhibited Intervention limit methylcellulose nasal Nasal cavity Nasal spray Nasal Sprays offer pandemic physical primary mechanism produced product provided reduced required respiratory respiratory viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus spray Spread Transmission variant variety virus virus entry virus level virus levels [DOI] 10.3390/v13122345 PMC 바로가기 [Article Type] Communication
COVID-19 Anosmia: High Prevalence, Plural Neuropathogenic Mechanisms, and Scarce Neurotropism of SARS-CoV-2?COVID-19 ANOSMIA : SARS-COV-2의 높은 유병률, 복수의 신경 병원성 메커니즘 및 부족한 신경 프로즘?Review Published on 2021-11-042022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus analyzed angiotensin angiotensin-converting enzyme 2 Anosmia apical surface appear causative pathogen cause Cell cellular Characteristics convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytological damages examined expression in some Infection lack mechanism molecular nasal Nasal cavity neurons Neuropathology ODs olfactory olfactory bulb olfactory dysfunction Olfactory epithelium Pathogenesis Perspective Plural Prevalence priming protease receptor respiratory respiratory epithelium respiratory virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neurotropism SARS-CoV-2 receptor Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structure susceptibility target transmembrane serine protease transmembrane serine protease 2 underlie Viral viral infection [DOI] 10.3390/v13112225 PMC 바로가기 [Article Type] Review