Immunogenicity and protectivity of intranasally delivered vector-based heterologous prime-boost COVID-19 vaccine Sputnik V in mice and non-human primatesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accompanied Blood clinical investigation Coverage COVID-19 COVID-19 pandemic COVID-19 vaccine cytokine release Diseases effective effort elicit Gam-COVID-Vac Health heterologous prime-boost IgA antibody IgG immune response Immunity immunization immunogenic immunogenicity Infection intranasal intranasal vaccine. intranasally K18-hACE2 transgenic mice less lung immunopathology mice mononuclear cell Mortality mucosal nasal mucosa neutralizing antibody non-human primate pandemic Peripheral blood Prevent proliferation protective immunity provided revaccination robust SARS-CoV-2 SARS-COV-2 infection SARSCoV-2 serum Sputnik V systemic and local the vaccine Transmission vaccination Vaccination strategy Vaccine vaccine candidate variants of concern virus virus infection virus spread [DOI] 10.1080/22221751.2022.2119169 PMC 바로가기
Diagnostic accuracy of a novel SARS CoV-2 rapid antigen test and usefulness of specimens collected from the anterior nasal cavityArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] Accuracy Ag-RDT age Antigen collected criteria cycle threshold Cycle threshold value diagnostic Diagnostic accuracy enrolled Hospitalization meet moderate nasal nasal mucosa nasopharyngeal Patient polymerase chain primary end point provide Rapid diagnostic test real-time polymerase chain reaction remained SARS CoV-2 SARS-CoV-2 sensitivity Sensitivity and specificity specificity specimen specimens utility Viral load World Health Organization [DOI] 10.1016/j.ijid.2022.09.018 PMC 바로가기
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificityArticle Published on 2022-10-032022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] airway analyzed antiviral immunity Breakthrough infection CD4+ T cell CD8+ COVID-19 COVID-19 vaccinee feature highlight Immunity immunological induce Infection nasal nasal mucosa persistence phenotype Primary infection Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 vaccination SARS-CoV-2-infected cell specificity suppress T cell T cell response vaccination vaccinee [DOI] 10.1084/jem.20220780 PMC 바로가기
Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathologyArticle Published on 2022-09-292022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Adaptive immune response addition antibodies antibody Beta Cell coronavirus coronavirus disease COVID-19 COVID-19 vaccines CpG cross-protective develop feature Gamma IgA antibody IgG antibody immunopathology Infection initial intranasal intranasal vaccination intranasally investigated less lung Lung eosinophilic immunopathology Lymph node mice mucosa nasal nasal mucosa oligonucleotides pandemic potential risk Prevent Protective protective effect reducing Respiratory disease risk SARS-CoV-2 SARS-CoV-2 variant secretory secretory IgA secretory IgA antibody. serum spike-specific IgG subcutaneous vaccination subcutaneously T helper Th1 Th2 Trimeric spike protein upper respiratory tract vaccination Vaccine variant variants viral challenge virus infection viruses [DOI] 10.1016/j.vaccine.2022.08.049 PMC 바로가기
Differential susceptibility to SARS-CoV-2 in the normal nasal mucosa and in chronic sinusitis정상 비점막 및 만성 부비동염에서 SARS-CoV-2에 대한 감수성 감수성Article Published on 2022-08-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2-expressing cell ACE2-expressing cells acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral immune response association Brain chronic Chronic rhinosinusitis close monitoring coronavirus CRS Culture deficiency disease eosinophils Eosinophils Human nasal mucosa Evidence gene expression difference gene expression differences high risk Human increase in individuals Infection investigated lung mechanism nasal nasal mucosa other organ other organs Patient progression reservoir respiratory tract rhinosinusitis SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Subtypes suggested susceptibility susceptible tissue tissue culture Transmission viral infection viral replication [DOI] 10.1002/eji.202249805 PMC 바로가기 [Article Type] Article
Nasal Mucosa Exploited by SARS-CoV-2 for Replicating and Shedding during ReinfectionArticle Published on 2022-07-232023-07-10 Journal: Viruses [Category] COVID19(2023년), [키워드] nasal mucosa Reinfection replicating and shedding. SARS-CoV-2 Syrian hamsters [DOI] 10.3390/v14081608 PMC 바로가기
Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial호흡기 감염 감소를 위한 아스토드리머 나트륨 항바이러스 비강 스프레이는 무작위 대조 시험에서 안전하고 내약성이 우수합니다.Randomized Controlled Trial Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] absorbed Absorption Administered administration adverse event All participants Antiviral applied clinical clinical investigation clinical trial clinically Cohort Community community acquired dendrimer double-blinded Effects examination finding examination findings exploratory exposure to followed by four times daily Frequency healthy volunteer help in vitro Infection initial intensity Intensive Mild nasal Nasal cavity nasal mucosa Nasal spray New nostril occurred other respiratory virus Other respiratory viruses participant Placebo placebo-controlled primary endpoint product Randomized Randomized controlled trial receiving reduce reducing Registered registry respiratory infection respiratory virus Respiratory virus infections respiratory viruses Safe safety population SARS-CoV-2 serious AEs severity shown sodium spray Spread systemically TEAE TEAEs Tolerability Treatment Trial registration utility vaginal mucosa Viral load virucidal Withdrawal [DOI] 10.1038/s41598-022-14601-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Small-molecule metabolome identifies potential therapeutic targets against COVID-19소분자 대사체는 COVID-19에 대한 잠재적인 치료 표적을 식별합니다Article Published on 2022-06-152022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] Accuracy biochemical change characterized composed Concentration controls COVID-19 COVID-19 infected individual COVID19 COVID19 patient disease severity evaluate host cell identify Infection metabolome metabolomic signature microbes nasal nasal mucosa nasopharyngeal Patient potential therapeutic target potential therapeutic targets primer produced qRT-PCR R 2 respiratory respiratory syncytial virus RSV SARS-CoV-2 significantly significantly increased small molecule tested transmitted unique viral infection Viral load virus [DOI] 10.1038/s41598-022-14050-y PMC 바로가기 [Article Type] Article
Bovine colostrum-derived antibodies against SARS-CoV-2 show great potential to serve as prophylactic agentsSARS-CoV-2에 대한 소 초유 유래 항체는 예방제 역할을 할 수 있는 큰 잠재력을 보여줍니다Article Published on 2022-06-102022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome Administered angiotensin-converting enzyme 2 antibody block Blood boost Cell Characteristics clinical study colostrum coronavirus cow defined health system immunization immunized Immunoglobulin in vitro assays Interaction mechanism NAb NAbs nasal nasal mucosa neutralizing antibody other disease presenting Prophylactic prophylactic treatment Protein purified RBD Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 social distancing Spread subjects surface receptor trimeric S protein vaccination virus virus entry wearing masks [DOI] 10.1371/journal.pone.0268806 PMC 바로가기 [Article Type] Article
Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination Research Published on 2022-06-012022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] adjusted Blood Ccr6 CD107a CD4+ cell CD4+ T cell CD8+ T cell Cell clinical trials contribute COVID-19 vaccination COVID-19 vaccine Cytokines decrease Donor doses Efficacy elevate expansion expressing expression flow cytometry increase in increases in less linear memory mRNA nasal nasal mucosa Pfizer-BioNTech phenotype protective immunity SARS-CoV-2 SARS-CoV-2 spike peptide second dose shown Stimulation subset Swab T cell upper respiratory tract vaccination Vaccine vaccine dose Vaccines [DOI] 10.1038/s41467-022-30913-4 [Article Type] Research