Nasal sprays for treating COVID-19: a scientific noteReview Published on 2023-02-272024-09-05 Journal: Pharmacological Reports [Category] update2024, [키워드] clinical trials devices Immunity Nasal route Nasal spray nasal vaccine SARS-CoV-2 [DOI] 10.1007/s43440-023-00463-7 PMC 바로가기 [Article Type] Review
Interferon-α-2b Nasal Spray for Treating SARS-CoV-2 Omicron Variant-Infected ChildrenLetter to Editor Published on 2023-02-212024-09-05 Journal: Journal of Clinical Immunology [Category] update2024, [키워드] children Interferon-α-2b Nasal spray SARS-CoV-2 Omicron variant [DOI] 10.1007/s10875-023-01452-4 PMC 바로가기 [Article Type] Letter to Editor
In vitro activity of cysteamine against SARS-CoV-2 variantsArticle Published on 2022-09-012022-11-15 Journal: Molecular genetics and metabolism [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Alpha antiviral activity application Breakthrough infection caused Concentration Contagion Continuous coronavirus COVID-19 pandemic Culture cysteamine Cysteamine HCl cystinosis Disulfides effective FDA-approved drug HCl in vitro individuals Infection inhibit inhibited less limit mitigate nasal Nasal spray ocular Omicron variant ophthalmic Orphan Orphan Drug Patient populations Prevent QID receive required SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant shown Spread tissue Transmission treat Treatment vaccinated individual Vaccine variant variants of SARS-CoV-2 Vero Cell viral inhibition while wild type [DOI] 10.1016/j.ymgme.2022.08.009 PMC 바로가기
SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trialArticle Published on 2022-08-012022-10-06 Journal: Lancet Reg Health Southeast Asia [Category] 진단, [키워드] 1:1 95% CI accelerate accelerated age Anti-viral treatment assessment baseline clearance clinical trial Comorbidities comparable Concentration COVID-19 COVID-19 illness defined demonstrated double-blind Endpoint evaluated funding greater greater transmissibility high risk individuals infected with SARS-CoV-2 Laboratory Limited median Mild multicentre mutate nasal Nasal spray nasal swab nitric oxide nostril parallel group Patient pharmaceutical Placebo placebo-controlled polymerase chain primary analysis population progression proportion provided Randomized randomized trial receiving reduce reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 RNA secondary Seven study medication symptomatic the placebo group therapy Treatment treatment difference vaccination Viral load virus virus clearance virus RNA [DOI] 10.1016/j.lansea.2022.100036 PMC 바로가기 [Article Type] Article
Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial호흡기 감염 감소를 위한 아스토드리머 나트륨 항바이러스 비강 스프레이는 무작위 대조 시험에서 안전하고 내약성이 우수합니다.Randomized Controlled Trial Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] absorbed Absorption Administered administration adverse event All participants Antiviral applied clinical clinical investigation clinical trial clinically Cohort Community community acquired dendrimer double-blinded Effects examination finding examination findings exploratory exposure to followed by four times daily Frequency healthy volunteer help in vitro Infection initial intensity Intensive Mild nasal Nasal cavity nasal mucosa Nasal spray New nostril occurred other respiratory virus Other respiratory viruses participant Placebo placebo-controlled primary endpoint product Randomized Randomized controlled trial receiving reduce reducing Registered registry respiratory infection respiratory virus Respiratory virus infections respiratory viruses Safe safety population SARS-CoV-2 serious AEs severity shown sodium spray Spread systemically TEAE TEAEs Tolerability Treatment Trial registration utility vaginal mucosa Viral load virucidal Withdrawal [DOI] 10.1038/s41598-022-14601-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Drug-Free Nasal Spray as a Barrier against SARS-CoV-2 and Its Delta Variant: In Vitro Study of Safety and Efficacy in Human Nasal Airway EpitheliaArticle Published on 2022-04-062023-07-01 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, [키워드] barrier Bentonite drug-free medical device nasal epithelium Nasal spray Prophylactic protection SARS-CoV-2 Treatment [DOI] 10.3390/ijms23074062 PMC 바로가기 [Article Type] Article
The vital role of animal, marine, and microbial natural products against COVID-19Covid-19에 대한 동물, 해양 및 미생물 천연 제품의 중요한 역할Review Published on 2022-03-022022-09-10 Journal: Pharmaceutical Biology [Category] 신약개발, 치료제, [키워드] 3CLpro animal Anti-inflammatory Antiviral approach Bromelain carrageenan clinical trial clinical trials Combination combination treatment Context COVID-19 COVID-19 therapy COVID19 database derivative Direct Drug development Effect Efficacy evaluated flavonoids hACE2 highlighting host proteins immunomodulatory properties in silico inhibitory less management mechanism microbial microbial products microorganisms MOST nasal Nasal spray NF-κB objective omega-3 omega-3 supplementation organism outbreak pandemic Pathogenesis peptide peptides pharmacological plants PLPro Prevent profile quercetin raw data researcher Result SARS-CoV-2 SARS-CoV-2coronavirus Science Science Direct searched synergistic synergistic effects tannins target tested therapy these compound these compounds Treatment Viral viral entry Vitamin C Zinc [DOI] 10.1080/13880209.2022.2039215 PMC 바로가기 [Article Type] Review
Antiviral Activities of Algal-Based Sulfated Polysaccharides조류계 황산다당류의 항바이러스 활성Review Published on 2022-02-092022-09-10 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 변종, 치료제, [키워드] activity Alpha Antiviral antiviral agent Antiviral agents Beta carrageenan COVID-19 pandemic Culture Delta effective Efficacy feature Gamma highlight human coronavirus include Isolation macro macroalgae marine plants microalgae nasal Nasal spray offer omicron Omicron variants patients plants Probability provide Safe social distancing sulfated polysaccharide sulfated polysaccharides Toxicity Vaccine development variants of SARS-CoV-2 viral disease [DOI] 10.3390/molecules27041178 PMC 바로가기 [Article Type] Review
Cluster randomised, controlled, triple-blind trial assessing the efficacy of intranasally administered virus-neutralising bovine colostrum supplement in preventing SARS-CoV-2 infection in household contacts of SARS-CoV-2-positive individuals: a study protocolSARS-CoV-2 양성 개인의 가정 접촉자에서 SARS-CoV-2 감염을 예방하는 데 비강 투여된 바이러스 중화 소 초유 보충제의 효능을 평가하는 클러스터 무작위, 통제, 삼중 맹검 시험: 연구 프로토콜Study Protocol Published on 2022-01-312022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] Administered anti-SARS-CoV-2 antibody ARMS bovine close contact Cluster colostrum Course COVID-19 cow Efficacy epithelial cells evaluate help household contact household contacts household transmission Households human body index case Infection Infection transmission Intervention intranasally Laboratory-confirmed COVID-19 Measures nasal Nasal Epithelial cells Nasal spray Neutralising Antibodies pandemic Placebo placebo-controlled prevention prevention strategies randomised Randomly risk of infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Spike protein study hypotheses Study protocol Transmission Treatment Trial triple-blind [DOI] 10.1186/s13063-022-06039-9 PMC 바로가기 [Article Type] Study Protocol
Nasally inhaled therapeutics and vaccination for COVID‐19: Developments and challengesReview Published on 2021-12-142022-10-30 Journal: MedComm [Category] COVID-19, [키워드] ACE2 addition administration Antiviral clearance COVID‐19 COVID‐19 management develop development Effect effective effective delivery Efficacy enzyme evade examined Factor Inhaled inhaled vaccine initial intramuscular vaccination intranasal lactobacillus management medication Medicines modifications Mucociliary clearance nasal Nasal spray physiological Region Replication SARS‐CoV‐2 Therapies translocation Transmission vaccination Vaccine Variability variant viral entry viral infection [DOI] 10.1002/mco2.101 PMC 바로가기 [Article Type] Review