National Institutes of Health

[키워드] MB-MSCs Menstrual blood-derived Mesenchymal Stromal Cells 3-dioxygenase ACE2angiotensin converting enzyme 2 acute graft-versus-host disease acute respiratory distress syndrome Adipose Tissue derived Mesenchymal Stromal Cells admadministration administration alanine aminotransferase Allo-MSCsAllogeneic Mesenchymal Stromal Cells Alloallogeneic Allogeneic Allogeneic Mesenchymal Stromal Cells ALTalanine aminotransferase angiotensin converting enzyme 2 anti-inflammatory property ARDS ARDSacute respiratory distress syndrome Aspartate aminotransferase ASTaspartate aminotransferase AT-MSCsAdipose Tissue derived Mesenchymal Stromal Cells AT2type 2 alveolar cells of the lungs BALFbronchoalveolar lavage fluid BM-MSCsbone marrow derived MSCs body weight bone marrow derived MSCs Bronchoalveolar lavage fluid bwBody weight C-reactive protein cAMPcyclic adenosine monophosphate candidate CDcluster of differentiation Cell clinical clinical trial cluster of differentiation complex conducted Coronavirus disease 2019 coronavirus disease of 2019 COVID-19 COVID-19Coronavirus disease of 2019 CRPC-reactive protein cyclic adenosine monophosphate cytokine Daewoong Pharmaceutical’s Mesenchymal Stromal Cells DCsdendritic cells dendritic cells driven by DSCsPlacenta-derived decidua stromal cells DW-MSCsDaewoong Pharmaceutical’s Mesenchymal Stromal Cells EVsextracellular vesicles Extracellular vesicles Fas ligands Fas-LFas ligands FDAFood and Drug Administration FGFfibroblast growth factor fibroblast growth factor Food and Drug Administration forkhead box P3 + FOXP3 +forkhead box P3 + G-CSFgranulocyte colony-stimulating factor Gal-1galectin-1 Gal-3galectin-3 Gal-9galectin-9 galectin-1 galectin-3 Galectin-9 GM-CSFgranulocyte macrophage-colony stimulating factor granulocyte colony-stimulating factor granulocyte macrophage-colony stimulating factor growth factor GvHDacute graft-versus-host disease HB-AT-MSCsHope Biosciences autologous adipose-derived mesenchymal stromal cells HdHigh dose hepatocyte growth factor HGFhepatocyte growth factor High dose HLAHuman leukocyte antigen Hope Biosciences autologous adipose-derived mesenchymal stromal cells human leukocyte antigen ICUIntensive Care Unit IDOIndoleamine 2 IFN-γinterferon-γ IL-10interleukin-10 IL-1interleukin-1 IL-1βinterleukin-1β IL-2 receptor IL-2interleukin-2 IL-2RIL-2 receptor IL-4interleukin-4 IL-6interleukin-6 IL-7Interleukin 7 IL-7interleukin-7 IL-8interleukin 8 IL-9interleukin IL1-αinterleukin 1-α IL1-βinterleukin 1-β IL1RaInterleukin-1 receptor antagonist immune dysregulation immunological immunomodulatory IMVInvasive mechanical ventilation Indoleamine 2 inducible protein 10 inflammatory process inhalation INHinhalation intensive care unit interferon-γ interleukin interleukin 1-α interleukin 1-β Interleukin 7 interleukin 8 interleukin-1 Interleukin-1 receptor antagonist interleukin-10 interleukin-1β interleukin-2 Interleukin-4 interleukin-6 interleukin-7 intravenous Invasive mechanical ventilation IP-10inducible protein 10 IVintravenous keratinocyte growth factor KGFkeratinocyte growth factor lactate dehydrogenase LDHlactate dehydrogenase LdLow dose lipopolysaccharide low dose LPSlipopolysaccharide major histocompatibility complex management MAPKmitogen-activated protein kinase MCP-1monocyte chemoattractant protein-1 Mesenchymal stromal cell Mesenchymal stromal cells MHCMajor Histocompatibility Complex microRNA miRNAmicroRNA MIS-Cmultisystem inflammatory syndrome in children mitogen-activated protein kinase monocyte chemoattractant protein-1 MSCs MSCsmesenchymal stromal cells multisystem inflammatory syndrome in children nanovesicles National Institutes of Health natural NETsNeutrophil Extracellular Traps Neutrophil extracellular traps NF-κBnuclear factor-kappa B NIHNational Institutes of Health nitric oxide NKnatural NONitric Oxide nuclear factor-kappa B NVsnanovesicles occur PD-1programmed cell death protein 1 PD-L1programmed death ligand-1 PGE2prostaglandin E2 pharmacological management PL-MSCsPlacental-derived Mesenchymal Stromal Cells Placenta-derived decidua stromal cells placental expanded Placental-derived Mesenchymal Stromal Cells PLX-PADplacental expanded programmed cell death protein 1 programmed death ligand-1 prostaglandin E2 protein spike public health reactive oxygen species Regulatory T cell Respiratory failure RFrespiratory failure ROSreactive oxygen species SARS-CoV-2severe acute respiratory syndrome coronavirus 2 Secretome severe acute respiratory syndrome coronavirus 2 severe COVID-19 Severe respiratory distress signal transducer activators of transcription-3 Sprotein spike STAT3signal transducer activators of transcription-3 syndrome TGF-β1transforming growth factor-β1 TGFtransforming growth factor the cytokine storm the disease therapeutic therapy TLRtoll-like receptors TNF-α-stimulating gene 6 TNF-αtumor necrosis factor-α TNFTumor Necrosis Factor Toll-like receptors transforming growth factor transforming growth factor-β1 treat Tregregulatory T cell TSG-6TNF-α-stimulating gene 6 tumor necrosis factor tumor necrosis factor-α type 2 alveolar cells of the lungs UC-MSCsumbilical cord derived MSCs umbilical cord derived MSCs vascular endothelial growth factor VEGFvascular endothelial growth factor Wharton’s Jelly–derived Mesenchymal Stromal Cells WJ-MSCsWharton’s Jelly–derived Mesenchymal Stromal Cells
[DOI] 10.1016/j.cytogfr.2022.07.002 [Article Type] Mini review