Galectin-3-ITGB1 Signaling Mediates Interleukin 10 Production of Hepatic Conventional Natural Killer Cells in Hepatitis B Virus Transgenic Mice and Correlates with Hepatocellular Carcinoma Progression in PatientsArticle Published on 2024-05-072024-09-05 Journal: Viruses [Category] update2024, [키워드] galectin-3 HBV Interleukin 10 ITGB1 natural killer cell [DOI] 10.3390/v16050737 PMC 바로가기 [Article Type] Article
Single-cell transcriptomics reveal hyperacute cytokine and immune checkpoint axis in patients with poor neurological outcomes after cardiac arrestArticle Published on 2023-05-272024-09-05 Journal: Med (New York, N.Y.) [Category] update2024, [키워드] Cardiac arrest cytokine immune checkpoint Inflammation Interferon-gamma monocyte natural killer cell nectin-2 Peripheral blood mononuclear cells Single-cell RNA-sequencing [DOI] 10.1016/j.medj.2023.05.003 PMC 바로가기 [Article Type] Article
STAT1 is associated with NK cell dysfunction by downregulating NKG2D transcription in chronic HBV-infected patientsArticle Published on 2022-11-012023-06-13 Journal: Immunobiology [Category] B형 간염, [키워드] Chronic hepatitis B infection Hepatitis B envelope antigen natural killer cell NKG2D PD-1 Stat1 TIM-3 [DOI] 10.1016/j.imbio.2022.152272
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다Review Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors understanding variants of concern Variation viral infection viral infections VOCs [DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review
A simple model of COVID-19 explains disease severity and the effect of treatments Research Published on 2022-08-202022-10-05 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법, 치료제, [키워드] Administered administration Analysis Antiviral Asymptomatic Cell Clinical finding Clinical outcome condition COVID-19 damage-associated molecular pattern damaged cell DAMP DAMPs disease severity dysregulated effect of treatment effort explain expressing hyperinflammation hypoxia infected cell Infection Inflammation interferon response lack less likelihood mathematical molecular natural killer cell Neutrophil extracellular traps PAMP PAMPs pathogen pathogen-associated molecular pattern pathogenesis of COVID-19 producing SARS-COV-2 infection severe COVID-19 Treatment Treatment strategies Viral load [DOI] 10.1038/s41598-022-18244-2 [Article Type] Research
COVID-19 and the Immune Response: A Multi-Phasic Approach to the Treatment of COVID-19COVID-19와 면역 반응: COVID-19 치료에 대한 다단계 접근Review Published on 2022-08-032022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive approach cause Characteristics Complication Consequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathology cytokine Cytokine storm disease exacerbated flu-like symptom flu-like symptoms Hyperactivation identify IL-6 immune immune mechanism immune response Immunosuppressant immunosuppressants Immunotherapy Infection initial involved Killer cell life-threatening monoclonal monoclonal antibodies monoclonal antibody multi-phasic multiphasic natural killer natural killer cell Replication SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Stage symptom duration Symptoms systematic review Treatment treatment approach viral replication [DOI] 10.3390/ijms23158606 PMC 바로가기 [Article Type] Review
Natural killer cells in antitumour adoptive cell immunotherapy Reviews Published on 2022-07-252022-10-05 Journal: Nature Reviews Cancer [Category] 바이오마커, 임상, 치료기술, 치료법, [키워드] anticancer approach Cancer CAR Cell cells chimeric antigen receptor cytokine cytokine production cytotoxicity driving Efficacy evaluate expression identify immune response Immunity Immunotherapy infected cell innate lymphoid cell intrinsic mechanism modulate natural natural killer cell NK cell NK cell-based therapy NK cells Patient persistence review specificity Strategy T cell therapy Treatment turn unique [DOI] 10.1038/s41568-022-00491-0 [Article Type] Reviews
Cellular therapies for the treatment and prevention of SARS-CoV-2 infectionSARS-CoV-2 감염의 치료 및 예방을 위한 세포 요법Article Published on 2022-07-212022-09-11 Journal: Blood [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antiviral Blood blood disorders cells cellular immunity Cellular therapies cellular therapy coronavirus described disorder Efficacy feasibility immune immune modulation include increased risk Infection Mesenchymal stromal cells modulating natural killer cell Natural killer cells PROTECT Regulatory T cell regulatory T cells Respiratory disease SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe respiratory disease stromal cells suppressed T cells therapy Treatment Trial viral shedding virus-specific T cell vulnerable patient [DOI] 10.1182/blood.2021012249 PMC 바로가기 [Article Type] Article
The KIR2DL2/HLA-C1C1 Gene Pairing Is Associated With an Increased Risk of SARS-CoV-2 InfectionKIR2DL2/HLA-C1C1 유전자 쌍은 SARS-CoV-2 감염 위험 증가와 관련이 있습니다Article Published on 2022-07-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence antiviral response association blood sample Blood samples causative agent Cell characterized controls COVID-19 COVID-19 infection COVID-19 pathogenesis COVID-19 patient COVID-19 patients dependent on detect DNA early phase frequencies Frequency function healthy controls healthy individuals HLA HLA-C Host in healthy individual incidence of COVID-19 Increased individual Infection Interaction Killer cell KIR KIR2DL2 KIR2DL3 KIR2DS3 Ligand Mild natural killer cell Natural killer cells NK cells no correlation Occurrence Pairing PCR primer protective effect receptor Region risk factor SARS-CoV-2 SARS-COV-2 infection severe disease Signaling significantly higher statistical analysis the healthy virus [DOI] 10.3389/fimmu.2022.919110 PMC 바로가기 [Article Type] Article
Natural killer cell homing and trafficking in tissues and tumors: from biology to application Reviews Published on 2022-06-292022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] Affect Allogeneic Alter blood circulation Bone marrow Cancer Cancer immunotherapy cancer treatment cancers CAR cells cellular chemokine chemokine receptors chimeric antigen receptor clinical utility cytokine Cytokines Defense develop Evidence Ex vivo expansion Factor Factors homing Immunotherapy IMPROVE infiltration Innate lymphoid cells Integrins limit lymphoid organs lymphoid tissues mechanism microenvironment natural natural killer cell NK cell peripheral tissues profile receptors solid tumors Steady state subset tissue transcriptional transfer transferred Treatment [DOI] 10.1038/s41392-022-01058-z [Article Type] Reviews