A machine learning approach utilizing DNA methylation as an accurate classifier of COVID-19 disease severityArticle Published on 2022-10-192022-11-16 Journal: Scientific Reports [Category] 변종, [키워드] applied approach average benefit Classifier Cohort COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pandemic dataset DNA methylation Epigenetic external validation Gene Expression Omnibus identify increased risk individual logit Methylation methylation site NCBI non-infected outcome pathology platform Pneumonia processed produced provide random forest classification Receiver operator characteristic severe COVID-19 disease Therapies unique utility Vaccine variant [DOI] 10.1038/s41598-022-22201-4 PMC 바로가기
Effectiveness of prone position in acute respiratory distress syndrome and moderating factors of obesity class and treatment durations for COVID-19 patients: A meta-analysisResearch article Published on 2022-10-012022-10-05 Journal: Intensive & critical care nursing [Category] COVID19(2023년), SARS, 치료법, [키워드] 95% CI 95%CI acute respiratory distress acute respiratory distress syndrome Analysis article body mass index calculated CINAHL conducted coronavirus 2 COVID-19 COVID-19 patient effect size Effectiveness eligible experimental design Factor Final Invasive mechanical ventilation mean difference Meta-analysis methodology NCBI non-invasive ventilation obesity objective oxygen saturation PaO2 paO2/fiO2 Patient patients patients with COVID-19 prone Prone position prone positioning ProQuest Respiratory failure Result SARS-CoV-2 secondary outcome significantly SpO2 statistically significant syndrome Treatment Web of Science [DOI] 10.1016/j.iccn.2022.103257 [Article Type] Research article
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19Article Published on 2022-09-082022-11-16 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Against Analysis approved bioinformatics caused Clinical characteristics Clinical data contagious coronavirus Coronavirus disease 2019 correlation country COVID-19 COX Cytoscape downloaded drug drug target DrugBank evaluate evaluated Fatality rate FDA Features food functional Gene Expression GeneCards Genes GO enrichment analysis IL-17 IL12B IL6 include infected with COVID-19 Interaction KEGG LBP lung adenocarcinoma (LUAD) lung cancer patient management mechanism modulate molecular molecular docking Mortality NCBI network network pharmacology pandemic pathway Pathway analysis Patient Paxlovid Pharmacology Potential potential therapeutic target Prognosis prognostic receptor Regression model risk SARS-CoV-2 screened signaling pathway survival rate susceptibility SwissTargetPrediction target target gene TargetNet therapeutic target Transcriptome Treatment Venn diagram virus was performed was used while [DOI] 10.3389/fendo.2022.935906 PMC 바로가기
Identification of conserved regions from 230,163 SARS-CoV-2 genomes and their use in diagnostic PCR primer design230,163 SARS-CoV-2 게놈에서 보존 영역 식별 및 진단 PCR 프라이머 디자인에서의 사용Article Published on 2022-08-012022-09-11 Journal: Genes & genomics [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] addition Alpha amplification approach Beta bioinformatics can be used candidate Candidates characteristic conserved Coverage dataset Delta Diagnosis diagnostic Epsilon Eta evaluated exhibited False negative full-length Gamma genome sequence genomes genomic sequence GISAID GISAID EpiCoV database identification identify in silico Intensive Iota Multiple Multiple sequence alignment multiple sequence alignments NCBI nine NSP2 orf3a gene Outbreaks pandemic PCR PCR primer primer primer set primer sets Primers qPCR RdRP Region removal retrieved RNA sample RNA samples RT-qPCR S gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant sequence Sequence alignment target viral genome viral sequences was reduced Zeta [DOI] 10.1007/s13258-022-01264-7 PMC 바로가기 [Article Type] Article
Convolutional Neural Network Applied to SARS-CoV-2 Sequence ClassificationSARS-CoV-2 서열 분류에 적용된 컨볼루션 신경망Article Published on 2022-07-312022-09-11 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition approach Biotechnology cause caused center classification CNN Containment Contamination Convolutional neural network coronavirus COVID-19 deaths deep learning family genome sequence genomic sequence Health Organization instance limit mortality rate Mutation NCBI network Neural omicron Omicron variant organism outbreak pandemic parameters performed positive-sense RNA genome SARS-CoV-2 sequence sequences severe acute respiratory syndrome Coronavirus Spread subgenus subsequent the disease Transmission Treatment variant virus viruses World Health Organization [DOI] 10.3390/s22155730 PMC 바로가기 [Article Type] Article
Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss in Spike진화하는 SARS-CoV-2 계통에 걸친 펩티도돔 감시, 스파이크에서 T 세포 에피토프 손실 가능성이 가장 큰 변이체 중 뉴클레오캡시드에서 HLA 결합 보존 밝혀Article Published on 2022-06-232022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] Analysis Antigen B.1.1.529 binding candidate caused CD4+ T cell CD4+ T cells CD8+ comprehensive analysis concern conservation conserved Course COVID-19 disease dominant elicit epitope Epitopes Evidence Genome GISAID heterogeneity HLA immune response immune responses instance interest lineages Loss MOST Mutation N protein N proteins NCBI NIH nucleocapsid omicron pandemic peptide peptides performed Potential predicted Protein protein sequence provided Region remained S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage spike sustained T cells T-cell the N protein the S protein unique vaccination variant variants viral evolution viral variant Viral variants VoC VOCs Volume [DOI] 10.3389/fimmu.2022.918928 PMC 바로가기 [Article Type] Article
Identification of SARS-CoV-2 variants using viral sequencing for the Centers for Disease Control and Prevention genomic surveillance program질병 통제 예방 센터의 게놈 감시 프로그램을 위한 바이러스 시퀀싱을 사용한 SARS-CoV-2 변이체 식별Article Published on 2022-04-252022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Affect Analysis association B.1.617.2 Brazil CDC center Centers for Disease Control Chain Reaction choice Control Coverage COVID COVID-19 Critical Ct value Ct values cycle cycle threshold Delta diagnostics disease control disease severity Effectiveness Gamma genetic change Genetic changes genomic genomic sequencing GISAID highlight identification Illumina India initial Laboratory Lineage Metrics nasopharyngeal Nasopharyngeal swab NCBI next generation sequencing NovaSeq 6000 nucleic acid omicron oropharyngeal swab P.1 Patient performed platform polymerase chain polymerase chain reaction positive positive sample prevention protocol public health Quality control reverse transcription polymerase chain reaction RT-PCR RT-PCR Ct Saliva saliva samples sample collection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 sequencing SARS-CoV-2 surveillance SARS-CoV-2 variant SARS-CoV-2 viral selected sequence sequenced Sequencing sequencing coverage sequencing depth sequencing method submission Surveillance the SARS-CoV-2 genome the United State Therapeutics Transcription Transmission Treatment United States Vaccine Vaccines variant variant call variant calls variants was performed whole genome [DOI] 10.1186/s12879-022-07374-7 PMC 바로가기 [Article Type] Article
MALVIRUS: an integrated application for viral variant analysisMALVIRUS: 바이러스 변이체 분석을 위한 통합 애플리케이션Article Published on 2022-04-192022-09-11 Journal: BMC Bioinformatics [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis assist available data being Complete COVID-19 pandemic dataset demonstrated Effectiveness Efficiency Genotype genotyped genotyping GISAID globe Illumina Lineage Lineage classification NCBI produced provided recall required SARS-CoV-2 SARS-CoV-2 strain Sequence analysis sequencing data Spread supported Test the SARS-CoV-2 variant variants Variation variations viral strain viral strains viral variant virus [DOI] 10.1186/s12859-022-04668-0 PMC 바로가기 [Article Type] Article
Research progress in laboratory detection of SARS-CoV-2SARS-CoV-2의 실험실 검출 연구 진행Review Published on 2022-04-012022-09-11 Journal: Irish Journal of Medical Science [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] advancement analyzed antibody Antibody detection can not Characteristics clinical samples Complete complexity detection efficiency Detection sensitivity diagnosing Diagnosis disadvantage Disadvantages Efficiency false-negative false-negative results help highest Increases Laboratory Laboratory detection NCBI New coronavirus Nucleic acid detection nucleic acid testing nucleocapsid protein primer Primers Probability provided qRT-PCR ranged reported required Research SARS-CoV-2 SARS-CoV-2 detection SARSCoV-2 Serological detection target viral infection virus was used [DOI] 10.1007/s11845-021-02604-4 PMC 바로가기 [Article Type] Review
Emerging of composition variations of SARS-CoV-2 spike protein and human ACE2 contribute to the level of infection: in silico approachesSARS-CoV-2 스파이크 단백질과 인간 ACE2의 조성 변화가 감염 수준에 기여함: in silico 접근법Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 angiotensin bind binding affinity binds bioinformatics calculated Combination contribute COVID-19 detect determine docking domain eight FIVE Genetic variant global energy hACE2 human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in silico in silico Approach in silico software Interaction investigated Laboratory moderate NCBI nsSNPs pandemic pathogenic PPI processed Protein Protein docking protein-protein interaction RBD RBD variant RBD variants Receptor-binding domain retrieved risk of infection SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein sequence similarity significantly SNP SNPs Support the binding affinity V367F V483A variant variants Variation zone [DOI] 10.1080/07391102.2020.1841032 PMC 바로가기 [Article Type] Article