Necrosis – Communicable Diseases Research

The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockade

Article

Published on 2022-12-012022-11-15
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 변종, 진단,

Intestinal Infarction in COVID-19 Pandemic: A Case Series

Original Article

Published on 2022-11-072022-10-29
Journal: Iranian Journal of Pathology
[Category] COVID-19,

[키워드] Abdominal CT Scan blood flow Clinical data coagulation disorder collected Complication coronavirus coronavirus disease COVID-19 described digestive system disrupt events Evidence headache Health Imam include Infection infection process intestinal Iran Ischemia Mashhad Medical Sciences mesenteric ischemia Necrosis novel operative organs pathological finding Patient patients hospitalized physician reported respiratory symptoms Reza risk factor Sery severe COVID-19 Severe COVID-19 Infection Severe COVID-19 pneumonia Spread suggested Symptom thrombosis university Vascular visceral with COVID-19
[DOI] 10.30699/IJP.2021.525280.2600 PMC 바로가기 [Article Type] Original Article

B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman Primates

Article

Published on 2022-10-262022-11-16
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] addition Alpha animal model association B.1.351 Beta caused changes in Characteristics Chinese circulating Clinical signs contribute determine distribution drugs early stage Efficacy and safety elevated exhibited IFN-γ IL-17 Infection Inflammatory Inflammatory cytokine interferon gamma interleukin 17 investigated less Lower respiratory tract lung tissue mechanisms mutated Necrosis NHP NHPs nonhuman primate pathogenesis of SARS-CoV-2 pathogenic pathogenicity pathological changes primate provide pulmonary inflammation reduced replicated Research rhesus macaque SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe lung injury shedding spike-specific T-cell response strain Strains tissue TNF-α Transmission upper respiratory tract Vaccine variant variants of concern viral distribution viral shedding virulence virulence. virulent VoC VOCs were infected
[DOI] 10.1128/spectrum.02263-22 PMC 바로가기

Humoral immune response against BNT162b2 mRNA COVID-19 vaccine in patients with rheumatic disease undergoing immunosuppressive therapy: A Japanese monocentric study

Article

Published on 2022-10-212022-11-15
Journal: Medicine
[Category] COVID19(2023년), SARS, 진단,

[키워드] acute respiratory syndrome addition Analysis analyzed Antibody titer attenuate Baricitinib BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 vaccine Combination controls coronavirus coronavirus disease COVID-19 COVID-19 vaccine disease domain dose Glucocorticoids healthy volunteer humoral immune response immunomodulatory Immunosuppressant immunosuppressants immunosuppressive immunosuppressive agent Immunosuppressive medication impair inhibitor inhibitors interleukin-17 interleukin-6 investigated Japanese Kagawa methotrexate much lower Necrosis of BNT162b2 Outpatient Patient patients treated reduced rheumatic disease SARS-CoV-2 SARS-CoV-2 spike protein second dose serum serum antibody significantly significantly lower Spike protein the patient therapeutic agent Treatment university Vaccine
[DOI] 10.1097/MD.0000000000031288 PMC 바로가기

Pulmonary Involvement in SARS-CoV-2 Infection Estimates Myocardial Injury Risk

Article

Published on 2022-10-112022-11-15
Journal: Medicina
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] acute respiratory syndrome Admission age Alpha alveolar ambient biochemical biochemical marker Biomarker C reactive protein can be used cardiac injury chest scan Computerized tomography consecutive patients consolidation coronavirus correlated correlation COVID-19 COVID-19 complications COVID-19 patient COVID-19 risk factors CRP CT scan Diastolic blood pressure dysfunction elevated estimate Factor Factors fibrinogen group Hospitalization IL-6 Infection Inflammatory marker Injury interleukin-6 interlobular septal thickening interstitial Involvement lactate dehydrogenase LDH lesion lung Lung disease lung involvement material multisystemic myocardial injury myocardial injury. myocardial involvement Myoglobin Necrosis non-specific NT-proBNP objective Observational cohort study occurred parameters pathology Patient Patient care performed peripheral oxygen saturation Pneumonia pulmonary pulmonary involvement pulmonary lobe radiological Registered respiratory rate respiratory rates Result risk routine SARS-CoV-2 SARS-COV-2 infection Serum ferritin severity Sex significant difference Systolic blood pressure the disease the patient the study group TnI
[DOI] 10.3390/medicina58101436 PMC 바로가기

Circulating tumor necrosis factor receptors are associated with mortality and disease severity in COVID-19 patients

Article

Published on 2022-10-112022-11-15
Journal: PLoS ONE
[Category] 바이오마커,

[키워드] addition age Biomarker body mass index C-reactive protein Chronic kidney disease CKD conducted coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRP CRP level D-dimer demonstrated diabetes discharged disease severity enrolled enzyme-linked immunosorbent examined glomerular filtration rate Hospitalization hospitalized patient Hyperinflammatory hypertension ICU ICU patient IL-6 influence intensive care Lactate Logistic regression analysis lymphocyte counts male males median Mortality multivariate Necrosis parameters Patient patients died patients with COVID-19 Prognosis receive receptor reported Retrospective study Serum level severity Significant significantly higher the patient TNF TNFR1 TNFR2 Treatment university utility were measured White blood cells
[DOI] 10.1371/journal.pone.0275745 PMC 바로가기

Adaptive immunity to SARS-CoV-2 infection: A systematic review

Article

Published on 2022-10-102022-11-15
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] acute respiratory syndrome adaptive Adaptive immunity addressed Alpha Antigen article B cell Biomarker case-control study caused CD4+ T cell CD8+ CD8+ T lymphocytes Cell cell types Characteristics clinical benefits Cohort studies coronavirus coronavirus disease Course COVID-19 Critically ill Critically ill patient cross-sectional CXCL9 Cytokines database disease English Evidence experimental evidence follicular HLA-DR humoral Humoral immunity IL-10 IL-13 IL-15 IL-17 IL-1α IL-2 IL-21 IL-22 IL-23 IL-4 IL-5 IL-7 immune system Immunity immunity. immunological Immunological memory immunopathological in vitro assays individuals inflammatory mediator involved leukocyte Ligand lymphocyte marker mild case Necrosis poor prognosis predominant produced programmed cell death progression Protein Regulatory T cell responsible SARS-CoV-2 SARS-COV-2 infection SciELO secretion severity Spanish subpopulation systematic review T helper T helper cell T lymphocyte T-cell Response Tfh TGF-β Th1 Th17 Th2 the antibody the disease TNF-α Treg tumor growth Vaccine variable
[DOI] 10.3389/fimmu.2022.1001198 PMC 바로가기

The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls-a prospective cohort study

Article

Published on 2022-10-052022-11-15
Journal: BMC Medicine
[Category] COVID19(2023년), SARS, 진단,

[키워드] 95% CI analyzed anti-RBD antibodies binding antibody antibody level blood sample bowel collected combination treatment Control controls COVID-19 declined defined disease dose enrolled Factor greater healthy healthy control healthy individuals Humoral immunity identify Immune-mediated inflammatory disease immunosuppressive Immunosuppressive medication Inflammatory bowel disease inhibitor initial interval median Multivariable regression Necrosis participant Patient patients persistence prospective cohort study Protein provided psoriatic arthritis RBD reduction reduction in Rheumatic diseases rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine serologic Serologic response. spike spondyloarthritis Support the receptor-binding domain the SARS-CoV-2 Therapies therapy ulcerative colitis vaccination vaccine dose
[DOI] 10.1186/s12916-022-02587-8 PMC 바로가기

Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection

Article

Published on 2022-10-042022-11-16
Journal: Cell Reports
[Category] COVID19(2023년), SARS, 변종,

The key role of Calpain in COVID-19 as a therapeutic strategy

Review

Published on 2022-10-012023-07-09
Journal: Inflammopharmacology
[Category] COVID19(2023년),

[키워드] Apoptosis calcium channel Inflammation Necrosis SARS-CoV-2.
[DOI] 10.1007/s10787-022-01002-1 PMC 바로가기 [Article Type] Review