Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cellsOmicron이 아닌 조상 SARS-CoV-2는 일차 소아 비강 상피 세포에서 덜 효율적으로 복제합니다Article Published on 2022-08-012022-09-11 Journal: PLoS Biology [Category] Coronavirus, SARS, 변종, [키워드] acute respiratory syndrome Adults Air-liquid interface antiviral response Biology biology of SARS-CoV-2 changes in children coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Delta delta variant epithelial cells Evidence Infection infections less Mild symptom nasal epithelial cell nasal epithelium NEC NECs omicron pediatric replicate replicated Replication respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly lower Support susceptible These data vaccination Viral RNA virus VOCs widespread [DOI] 10.1371/journal.pbio.3001728 PMC 바로가기 [Article Type] Article
LncRNA HCP5 Participates in the Tregs Functions in Allergic Rhinitis and Drives Airway Mucosal Inflammatory Response in the Nasal Epithelial Cellsarticle Published on 2022-02-052024-09-02 Journal: Inflammation [Category] 대상포진, [키워드] allergic rhinitis ATXN2L long noncoding RNA HCP5 miRNA-16 NECs regulatory T cells [DOI] 10.1007/s10753-022-01620-5 PMC 바로가기 [Article Type] article
Neuroradiological emergency consultations during the first year of the COVID-19 pandemicResearch Article Published on 2021-08-302022-10-30 Journal: Neurological Research and Practice [Category] COVID-19, [키워드] Affect age and gender Analysis analyzed Care change Computed tomography conditions conducted Consultations coronavirus COVID-19 COVID-19 pandemic COVID-19 testing declined distribution Effect Germany hospital incidence Infection measure NEC NECs not significant pandemic Patient reflect remained Result risk stroke supplementary material Transient ischemic attack Transmission university hospital Weekly with COVID-19 [DOI] 10.1186/s42466-021-00147-8 PMC 바로가기 [Article Type] Research Article
PEDV infection in neonatal piglets through the nasal cavity is mediated by subepithelial CD3 + T cellsResearch Article Published on 2021-02-172022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] Antiviral blood circulation catastrophic CD3 CD3+ T cells Contact DCs dendritic cell dissemination Effect epidemic diarrhea induce infect infected NEC Infection Infection of NEC Inflammatory cytokine intestinal intestinal mucosa intestine Invasion late stage nasal Nasal cavity nasal epithelial cell NECs Neonatal neonatal piglets PEDV replicate subepithelial T cell transfer virus [DOI] 10.1186/s13567-020-00883-w PMC 바로가기 [Article Type] Research Article
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profilesSARS-CoV-2 및 ORF8이 결여된 382-nt 결실 분리주에 의한 인간 비강 상피 세포의 감염은 유사한 바이러스 동역학 및 숙주 전사 프로필을 나타냅니다Research Article Published on 2020-12-072022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] absence airway airway epithelial cells anti-viral gene up-regulation anti-viral signaling pathway anti-viral signaling pathways apical side basolateral secretion causative agent cell type cell types comparable conserved expression coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 patients CXCL10 CXCL10 production cytokine cytokine production Cytokines differentiated NEC differentiated NECs distinct gene subset distinct gene subsets Duration of infection early response elevated elicited epithelial epithelial cell epithelial cells examined genomes global healthcare greater magnitude H3N2 healthy nasal-tissue highlight Host host gene expression Host immune response Host transcriptional response host-response hours post-infection hpi IL-6 Immune cell infiltration immune cells immune response impair in vitro In-vitro infancy infected cells infected NEC infected NECs Infection Infection of NEC Infection of NECs Infection with Δ382 infiltrating immune cell infiltrating immune cells Inflammatory response Influenza influenza strain late time-point late time-points less modulating Nasal Epithelial cells NECs Novel coronavirus novel coronavirus SARS-CoV-2 ORF8 other SARS-CoV-2 genes Pathogenesis patient sera patients plasticity post-infection time-point pro-inflammatory cytokine pro-inflammatory cytokines released reported reveal SARS-CoV-2 SARS-CoV-2 and Δ382 infection SARS-CoV-2 genes SARS-COV-2 infection Screening severe disease significantly similar replication kinetics similarities similarity Singapore stem cell stem cells subsequent cytokine production temporal up-regulation therapeutic node TNFα transcriptional transcriptional profile Transcriptome transcriptome analysis transcripts transcripts mapping understanding Viral viral clearance viral kinetics virus particle virus particles wild-type and Δ382 wild-type SARS-CoV-2 Δ382 Δ382 infected cell Δ382 infected cells Δ382 infection [DOI] 10.1371/journal.ppat.1009130 PMC 바로가기 [Article Type] Research Article