Safety and immunogenicity of MVC-COV1901 vaccine in older adults: Phase 2 randomized dose-comparison trialArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] 진단, [키워드] Administered adverse event age binding antibody clinical trial Comorbidities Comorbidity COVID-19 infection demonstrated dose double-blind elicited General population High dose High-dose immune response immunization immunogenicity immunosenescence Mild mortality rates MVC-COV1901 vaccine negative correlation Neutralizing Older older adult Older adults participant Phase 2 protein subunit vaccine Randomized regimen Registered robust Safety SARS-CoV-2 stratified subject Trial Vaccine [DOI] 10.1016/j.ijid.2022.08.021 PMC 바로가기
Viral load may impact the diagnostic performance of nasal swabs in nucleic acid amplification test and quantitative antigen test for SARS-CoV-2 detectionArticle Published on 2022-11-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] SARS, 치료기술, [키워드] amplification Antigen automated collected cycle threshold detect diagnostic early stage evaluated healthcare Measures NAAT nasal swab nasal swabs Nasopharyngeal swab nasopharyngeal swabs negative correlation nine NPs nucleic acid amplification nucleic acid amplification test patients with COVID-19 positive Quantitative Quantitative SARS-CoV-2 antigen test Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 detection significantly significantly higher significantly lower symptom onset tested Viral load were used [DOI] 10.1016/j.jiac.2022.07.023 PMC 바로가기
Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent MutationsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type [DOI] 10.1128/spectrum.01219-22 PMC 바로가기
Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materialsArticle Published on 2022-10-052022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Adsorption aerosol analysed antiviral potency caused Community Contact coronavirus coronavirus disease correlation doffing Efficacy equipment evaluated global public health healthcare Infection Ion m/z negative correlation no correlation Personal protective equipment Physicochemical properties Polymer positive PPE Protective reduction in Regression model SARS-CoV-2 transmission the SARS-CoV-2 titre Transmission transmission of SARS-CoV-2 virion virus while [DOI] 10.1038/s41598-022-20952-8 PMC 바로가기
Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19Article Published on 2022-10-012022-11-15 Journal: Clinical and Translational Medicine [Category] 바이오마커, [키워드] Administered association biological properties Biomarker ceramide characteristic clinical phenotype conditions control subject coronavirus disease Course COVID-19 Critical CRP D-dimer decrease develop disease severity dynamic early phase glycerophospholipids heterogeneity heterogeneous Infectious disease Laboratory testing Lipidomics lysophosphatidylcholine mechanism mice modulation negative correlation Phosphatidylcholine positive Prevent responsible serum severe COVID-19 severity shown sphingolipid sphingolipids sphingomyelin subject subjects suppress tissue treated unsaturated [DOI] 10.1002/ctm2.1069 PMC 바로가기
The Variation of Transcriptomic Perturbations is Associated with the Development and Progression of Various DiseasesArticle Published on 2022-09-262022-11-16 Journal: Disease Markers [Category] 유전자 메커니즘, [키워드] activities AIDS AIDS patient Algorithm analyzed applied association atrophic gastritis cardiovascular diseases caused cellular chronic obstructive clinical implication clinically controls COPD correlated correlation COVID-19 patient deficiency defined development digestive disease Disease diagnosis Disease progression Diseases Ejection fraction Endocrine diseases expiratory expression greater Health status heterogeneity ICU immune Infection intensive care investigated involved Kidney diseases liver diseases LVEF malaria mechanical ventilatory support negative correlation Neurological disorders non-ICU patients pathway patients Perturbation presymptomatic Prognosis pulmonary disease pulmonary tuberculosis Regulation respiratory diseases severity significantly syndrome the disease Therapies transcriptome datasets transcriptomic transcriptomic data treated upregulated upregulation Variation variety ventricular Viral load Volume [DOI] 10.1155/2022/2148627 PMC 바로가기
Antibody titers among healthcare workers for coronavirus disease 2019 at 6 months after BNT162b2 vaccinationArticle Published on 2022-09-162022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] acute respiratory syndrome age Analysis analyzed Anti-spike antibody antibody level Antibody titre BNT162b2 BNT162b2 vaccine Care conducted coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 decrease dose Factor female females healthcare healthcare worker Healthcare workers hospital IgG IgG antibody Japanese negative correlation participant Participants preserved Prospective Study Protein Regression SARS-CoV-2 side Side effects tested the vaccine vaccination were infected [DOI] 10.1016/j.vaccine.2022.08.035 PMC 바로가기
Evaluation of long-term antibody kinetics in healthcare workers vaccinated with inactivated COVID-19 Vero cell vaccine (CoronaVac), a propensity score-matched observational studyObservational Study Published on 2022-09-012022-10-04 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] age antibody kinetics approval binding antibody booster CLIA CoronaVac Course COVID-19 COVID-19 vaccines ELISA enzyme-linked immunosorbent evaluate Factors HCW HCWs healthcare worker immunoassay inactivated NAb negative correlation neutralizing antibody optic density Participants Pearson correlation propensity score analysis prospective observational study response SARS-CoV-2 SARS-CoV-2 antibody significant decrease significantly single center the antibody response the vaccine titer Turkey Vaccine Vero Cell was determined was performed were used [DOI] 10.1016/j.ijid.2022.05.007 PMC 바로가기 [Article Type] Observational Study
Long-term monitoring of drug consumption patterns during the COVID-19 pandemic in a small-sized community in Brazil through wastewater-based epidemiology폐수 기반 역학을 통해 브라질의 소규모 커뮤니티에서 Covid-19 Pandemic 동안 약물 소비 패턴의 장기 모니터링Article Published on 2022-09-012022-08-31 Journal: Chemosphere [Category] MERS, 바이오마커, 치료제, [키워드] Abuse affecting amphetamine Analysis Biomarker Brazil caffeine can be used cellular cellular phone closure cocaine Community complementary Consumption COVID-19 COVID-19 pandemic described drug epidemiological Epidemiology evaluated expressed followed by global public health health problem highest illicit drugs information Long-term monitoring MDMA methamphetamine negative correlation Nicotine P-value POCIS sampling polar reduced reduction in unemployment was used wastewater Wastewater-based epidemiology [DOI] 10.1016/j.chemosphere.2022.134907 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection- induced growth factors play differential roles in COVID-19 pathogenesisSARS-CoV-2 감염 유발 성장 인자는 COVID-19 발병 기전에서 다른 역할을 합니다Article Published on 2022-09-012022-09-11 Journal: Life sciences [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] adverse effect adverse effects angiopoietin association COVID-19 COVID-19 pathogenesis COVID-19 patient Critical Critically ill cytokine Cytokine storm Cytokine storms Cytokines D-dimer disease dysregulation EGF elevated Endothelial dysfunction EPO erythropoietin exhibited G-CSF growth factor Growth factors HGF Hospitalized ICU Inflammation Injury inverse correlation investigation marker moderate Myoglobin negative correlation non-ICU occur P-selectin Pathogenesis pathogenesis of COVID-19 pathophysiology PDGF plasma positive correlation reflected remained repair SARS-COV-2 infection selectin specific disease Thromboembolism tissue tissue injury Tissue injury. upregulated vague VEGF was performed [DOI] 10.1016/j.lfs.2022.120703 PMC 바로가기 [Article Type] Article