Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future DirectionsReview Published on 2024-08-172024-09-05 Journal: The Cochrane database of systematic reviews [Category] update2024, [키워드] antioxidant Neurodegenerative diseases oxidative stress reactive oxygen species Vitamin D [DOI] 10.3390/antiox13080996 PMC 바로가기 [Article Type] Review
PDE4D: A Multipurpose Pharmacological TargetReview Published on 2024-07-242024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] catechol moiety drug design Neurodegenerative diseases phosphodiesterases 4 phosphodiesterases 4D [DOI] 10.3390/ijms25158052 PMC 바로가기 [Article Type] Review
Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potentialReviews Published on 2024-06-252024-09-05 Journal: CNS Neuroscience & Therapeutics [Category] update2024, [키워드] low‐intensity ultrasound stimulation mechanosensitive channels Neurodegenerative diseases PIEZO1 place‐occupying damage [DOI] 10.1111/cns.14809 PMC 바로가기 [Article Type] Reviews
Innovative Therapeutic Strategies in Alzheimer’s Disease: A Synergistic Approach to Neurodegenerative DisordersReview Published on 2024-06-062024-09-05 Journal: Pharmaceuticals [Category] update2024, [키워드] Alzheimer’s disease antibody targeting Blood–brain barrier chemical targeting mRNA vaccine nanobodies Neurodegenerative diseases [DOI] 10.3390/ph17060741 PMC 바로가기 [Article Type] Review
Neuroprotective Effects of Curcumin in Neurodegenerative DiseasesReview Published on 2024-06-052024-09-05 Journal: Foods [Category] update2024, [키워드] Bioavailability Curcuma longa Nanoparticles Neurodegenerative diseases [DOI] 10.3390/foods13111774 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike Protein 1 Causes Aggregation of α-Synuclein via Microglia-Induced Inflammation and Production of Mitochondrial ROS: Potential Therapeutic Applications of MetforminArticle Published on 2024-05-312024-09-05 Journal: Biomedicines [Category] update2024, [키워드] Dopaminergic neuron Long COVID metformin microglia mitochondrial ROS Neurodegenerative diseases Neuroinflammation neurotoxin MPP+ SARS-CoV-2 spike protein 1 α-synucleinopathy [DOI] 10.3390/biomedicines12061223 PMC 바로가기 [Article Type] Article
Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim resultsArticle Published on 2024-05-142024-09-05 Journal: Nature Medicine [Category] update2024, [키워드] Neurodegenerative diseases Target validation [DOI] 10.1038/s41591-024-02973-0 PMC 바로가기 [Article Type] Article
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learningArticle Published on 2024-04-172024-09-05 Journal: Nature chemical biology [Category] update2024, [키워드] Cheminformatics Computational biology and bioinformatics Drug discovery Neurodegenerative diseases Single-molecule biophysics [DOI] 10.1038/s41589-024-01580-x PMC 바로가기 [Article Type] Article
Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2Article Published on 2024-04-162024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Cryoelectron microscopy iron Metalloproteins Mitochondrial proteins Neurodegenerative diseases [DOI] 10.1038/s41467-024-47310-8 PMC 바로가기 [Article Type] Article
CSF neurofilament light chain profiling and quantitation in neurological diseasesOriginal Article Published on 2024-04-162024-09-05 Journal: Brain Communications [Category] update2024, [키워드] mass spectrometry Neurodegenerative diseases neurofilament light chain [DOI] 10.1093/braincomms/fcae132 PMC 바로가기 [Article Type] Original Article